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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Modulation of activity of the striatal dopaminergic system during the hibernation cycle.

To evaluate how the activity of a well-established neurotransmitter pathway is modulated by a behavioral state, 3H-spiperone binding sites and dopamine (DA) and DA metabolite concentrations were measured in the striata of ground squirrels in 5 phases of the hibernation cycle. Whereas levels of striatal DA and its deaminated metabolite DOPAC did not change significantly, the concentrations of the O-methylated-deaminated metabolite, homovanillic acid (HVA), decreased in all phases of hibernation relative to euthermia. Striatal 3H-spiperone binding sites declined across the hibernation cycle in parallel with the reduction of HVA concentration; receptor binding affinity was unchanged by arousal state. In conjunction with previously reported findings, these results are consistent with the hypothesis that hibernation is associated with a down-regulation of the postsynaptic D2 receptors secondary to increased extracellular DA concentration and reduced DA degradation.[1]


  1. Modulation of activity of the striatal dopaminergic system during the hibernation cycle. Kilduff, T.S., Bowersox, S.S., Faull, K.F., Zeller-DeAmicis, L., Radeke, C.M., Ciaranello, R.D., Heller, H.C., Barchas, J.D., Dement, W.C. J. Neurosci. (1987) [Pubmed]
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