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Yoshida, S. et al.

In vitro effects of monobactams on Legionella pneumophila.

The effects of azthreonam and carumonam against Legionella pneumophila Philadelphia-1 strain in liquid medium and in phagocytic cells were examined. The minimum inhibitory concentration (MIC) of azthreonam for the bacteria was 12.5 micrograms/ml at a concentration of 1.4 X 10(4) colony forming units (CFU) and 25 micrograms/ml at a concentration of 1.4 X 10(5) CFU. MIC of carumonam was 25 micrograms/ml in both concentrations of the bacterial suspension. In guinea pig macrophages, both azthreonam and carumonam at a concentration of 100 micrograms/ml did not inhibit the multiplication of the bacteria.[1]

References

In vitro effects of monobactams on Legionella pneumophila. Yoshida, S., Mizuguchi, Y., Nikaido, Y. J. UOEH (1987) [Pubmed]

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