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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Legionella

 
 
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Disease relevance of Legionella

  • Identification of putative cytoskeletal protein homologues in the protozoan host Hartmannella vermiformis as substrates for induced tyrosine phosphatase activity upon attachment to the Legionnaires' disease bacterium, Legionella pneumophila [1].
  • As of 30 September 1979, 1005 confirmed cases of sporadic legionellosis caused by Legionella pneumophila serogroups 1 to 4 in U.S. residents had been reported to the Centers for Disease Control; 19% were fatal [2].
  • Classification of the Legionnaires' disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova [3].
  • Some unusual structural features of the B. henselae lipopolysaccharide, including the presence of a long-chain fatty acid, which are shared by the lipopolysaccharides of other bacteria causing chronic intracellular infections (e.g. Legionella and Chlamydia), may provide the molecular basis for low endotoxic potency [4].
  • However, in organisms like Acidithiobacillus ferrooxidans, Leptospira interrogans, Mesorhizobium loti, and Legionella pneumophila, one or both glucosamine residues are replaced with the sugar 2,3-diamino-2,3-dideoxy-d-glucopyranose [5].
 

Psychiatry related information on Legionella

  • In inbred mouse strains, permissiveness to intracellular replication of Legionella pneumophila is controlled by a single locus (Lgn1), which maps to a region within distal Chromosome 13 that contains multiple copies of the gene baculoviral IAP repeat-containing 1 (Birc1, also called Naip; refs. 1-3) [6].
  • These data suggest that the induction of TNF by Legionella bacteria during infection are involved in the non-specific host defense mechanisms, and that PMN activated by the TNF may be instrumental in clearing the organism from infected lung tissues, thereby protecting the animal [7].
 

High impact information on Legionella

  • Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila [6].
  • The organisms did not react with hyperimmune sera to Legionella pneumophila nor to several species of Rickettsia [8].
  • Mixtures that have been separated with supercritical carbon dioxide include resin acids with the empirical formula C20H30O2 and ubiquinones from bacterial cell wall extracts of Legionella pneumophila [9].
  • Here we describe a Birc1e-dependent signaling pathway that restricted replication of the intracellular pathogen Legionella pneumophila in mouse macrophages [10].
  • Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection [11].
 

Chemical compound and disease context of Legionella

 

Biological context of Legionella

 

Anatomical context of Legionella

 

Gene context of Legionella

  • High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis [26].
  • Toll-like receptor 4 is not involved in host defense against pulmonary Legionella pneumophila infection in a mouse model [27].
  • The roles of CXC chemokine-mediated host responses were examined with an A/J mouse model of Legionella pneumophila pneumonia [28].
  • Finally, treatment of PMN with recombinant IFN-gamma and recombinant TNF augmented their bactericidal activity against Legionella in a dose-dependent response [29].
  • The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2 [30].
 

Analytical, diagnostic and therapeutic context of Legionella

References

  1. Identification of putative cytoskeletal protein homologues in the protozoan host Hartmannella vermiformis as substrates for induced tyrosine phosphatase activity upon attachment to the Legionnaires' disease bacterium, Legionella pneumophila. Venkataraman, C., Gao, L.Y., Bondada, S., Kwaik, Y.A. J. Exp. Med. (1998) [Pubmed]
  2. Sporadic legionellosis in the United States: the first thousand cases. England, A.C., Fraser, D.W., Plikaytis, B.D., Tsai, T.F., Storch, G., Broome, C.V. Ann. Intern. Med. (1981) [Pubmed]
  3. Classification of the Legionnaires' disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova. Brenner, D.J., Steigerwalt, A.G., McDade, J.E. Ann. Intern. Med. (1979) [Pubmed]
  4. Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882T. Zähringer, U., Lindner, B., Knirel, Y.A., van den Akker, W.M., Hiestand, R., Heine, H., Dehio, C. J. Biol. Chem. (2004) [Pubmed]
  5. Oxidation and transamination of the 3"-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans. Role in the formation of lipid a molecules with four amide-linked acyl chains. Sweet, C.R., Ribeiro, A.A., Raetz, C.R. J. Biol. Chem. (2004) [Pubmed]
  6. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Diez, E., Lee, S.H., Gauthier, S., Yaraghi, Z., Tremblay, M., Vidal, S., Gros, P. Nat. Genet. (2003) [Pubmed]
  7. Protective effects of tumor necrosis factor in experimental Legionella pneumophila infections of mice via activation of PMN function. Blanchard, D.K., Djeu, J.Y., Klein, T.W., Friedman, H., Stewart, W.E. J. Leukoc. Biol. (1988) [Pubmed]
  8. Cat scratch disease: a bacterial infection. Wear, D.J., Margileth, A.M., Hadfield, T.L., Fischer, G.W., Schlagel, C.J., King, F.M. Science (1983) [Pubmed]
  9. Supercritical fluid chromatography. Gere, D.R. Science (1983) [Pubmed]
  10. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Zamboni, D.S., Kobayashi, K.S., Kohlsdorf, T., Ogura, Y., Long, E.M., Vance, R.E., Kuida, K., Mariathasan, S., Dixit, V.M., Flavell, R.A., Dietrich, W.F., Roy, C.R. Nat. Immunol. (2006) [Pubmed]
  11. Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. Molofsky, A.B., Byrne, B.G., Whitfield, N.N., Madigan, C.A., Fuse, E.T., Tateda, K., Swanson, M.S. J. Exp. Med. (2006) [Pubmed]
  12. Phase-variable expression of lipopolysaccharide contributes to the virulence of legionella pneumophila. Lüneberg, E., Zähringer, U., Knirel, Y.A., Steinmann, D., Hartmann, M., Steinmetz, I., Rohde, M., Köhl, J., Frosch, M. J. Exp. Med. (1998) [Pubmed]
  13. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens. Byrd, T.F., Horwitz, M.A. J. Clin. Invest. (1991) [Pubmed]
  14. Interaction between the legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone. Nash, T.W., Libby, D.M., Horwitz, M.A. J. Clin. Invest. (1984) [Pubmed]
  15. Interaction of primate alveolar macrophages and Legionella pneumophila. Jacobs, R.F., Locksley, R.M., Wilson, C.B., Haas, J.E., Klebanoff, S.J. J. Clin. Invest. (1984) [Pubmed]
  16. Intracellular killing of Legionella by erythromycin. Miller, M.F., Martin, J.R., Levy, N.L. Lancet (1984) [Pubmed]
  17. Estimation of Legionella pneumophila virulence by nitroblue-tetrazolium reduction. Halablab, M.A., Bazin, M., Richards, L. Lancet (1990) [Pubmed]
  18. The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site. Amor, J.C., Swails, J., Zhu, X., Roy, C.R., Nagai, H., Ingmundson, A., Cheng, X., Kahn, R.A. J. Biol. Chem. (2005) [Pubmed]
  19. Nucleotide sequence of htpB, the Legionella pneumophila gene encoding the 58-kilodalton (kDa) common antigen, formerly designated the 60-kDa common antigen. Sampson, J.S., O'Connor, S.P., Holloway, B.P., Plikaytis, B.B., Carlone, G.M., Mayer, L.W. Infect. Immun. (1990) [Pubmed]
  20. In vitro activity of gemifloxacin (SB-265805, LB20304a) against Legionella pneumophila and its pharmacokinetics in guinea pigs with L. pneumophila pneumonia. Edelstein, P.H., Shinzato, T., Doyle, E., Edelstein, M.A. Antimicrob. Agents Chemother. (2001) [Pubmed]
  21. Impaired clearance of aerosolized Legionella pneumophila in corticosteroid-treated rats: a model of Legionnaires' disease in the compromised host. Skerrett, S.J., Schmidt, R.A., Martin, T.R. J. Infect. Dis. (1989) [Pubmed]
  22. Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. Byrd, T.F., Horwitz, M.A. J. Clin. Invest. (1989) [Pubmed]
  23. Major cytoplasmic membrane protein of Legionella pneumophila, a genus common antigen and member of the hsp 60 family of heat shock proteins, induces protective immunity in a guinea pig model of Legionnaires' disease. Blander, S.J., Horwitz, M.A. J. Clin. Invest. (1993) [Pubmed]
  24. Activated macrophages infected with Legionella inhibit T cells by means of MyD88-dependent production of prostaglandins. Neild, A.L., Shin, S., Roy, C.R. J. Immunol. (2005) [Pubmed]
  25. MyD88-Dependent IFN-{gamma} Production by NK Cells Is Key for Control of Legionella pneumophila Infection. Spörri, R., Joller, N., Albers, U., Hilbi, H., Oxenius, A. J. Immunol. (2006) [Pubmed]
  26. High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis. Growney, J.D., Dietrich, W.F. Genome Res. (2000) [Pubmed]
  27. Toll-like receptor 4 is not involved in host defense against pulmonary Legionella pneumophila infection in a mouse model. Lettinga, K.D., Florquin, S., Speelman, P., van Ketel, R., van der Poll, T., Verbon, A. J. Infect. Dis. (2002) [Pubmed]
  28. Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells. Tateda, K., Moore, T.A., Newstead, M.W., Tsai, W.C., Zeng, X., Deng, J.C., Chen, G., Reddy, R., Yamaguchi, K., Standiford, T.J. Infect. Immun. (2001) [Pubmed]
  29. Induction of interferon-gamma and tumor necrosis factor by Legionella pneumophila: augmentation of human neutrophil bactericidal activity. Blanchard, D.K., Friedman, H., Klein, T.W., Djeu, J.Y. J. Leukoc. Biol. (1989) [Pubmed]
  30. The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2. Newton, C.A., Lu, T., Nazian, S.J., Perkins, I., Friedman, H., Klein, T.W. J. Leukoc. Biol. (2004) [Pubmed]
  31. Legionella and community-acquired pneumonia: a review of current diagnostic tests from a clinician's viewpoint. Waterer, G.W., Baselski, V.S., Wunderink, R.G. Am. J. Med. (2001) [Pubmed]
  32. Reactivity of serum from patients with suspected legionellosis against 29 antigens of legionellaceae and Legionella-like organisms by indirect immunofluorescence assay. Wilkinson, H.W., Reingold, A.L., Brake, B.J., McGiboney, D.L., Gorman, G.W., Broome, C.V. J. Infect. Dis. (1983) [Pubmed]
  33. Sequence analysis of the mip gene of the soilborne pathogen Legionella longbeachae. Doyle, R.M., Steele, T.W., McLennan, A.M., Parkinson, I.H., Manning, P.A., Heuzenroeder, M.W. Infect. Immun. (1998) [Pubmed]
  34. Outer membrane proteins from Legionella pneumophila serogroups and other Legionella species. Hindahl, M.S., Iglewski, B.H. Infect. Immun. (1986) [Pubmed]
 
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