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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of repeated injection sclerotherapy on acid gastroesophageal reflux.

Acid gastroesophageal reflux was determined by long-term pH monitoring in 19 consecutive variceal bleeders after 5 to 20 (mean, 10.3 +/- 1 SEM) sclerotherapy sessions with the flexible endoscope using polidocanol 1% as sclerosant. Fifteen cirrhotics with untreated varices served as controls. Percentage time of esophageal pH less than 4 (3.3 +/- 0.7 SEM vs. 5.2 +/- 2.2 in the controls) and mean duration of reflux episodes (2.9 +/- 0.4 vs. 3.0 +/- 0.7 min) showed no significant differences between both groups. The findings indicate that repeated injection sclerotherapy with the flexible endoscope does not lead to an enhancement of acid gastroesophageal reflux.[1]


  1. Effects of repeated injection sclerotherapy on acid gastroesophageal reflux. Sauerbruch, T., Wirsching, R., Holl, J., Gröbl, J., Weinzierl, M. Gastrointest. Endosc. (1986) [Pubmed]
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