Disease relevance of Dodecylnonaoxyethylene glycol monoether

• Randomised trial of fibrin glue versus polidocanol for bleeding peptic ulcer [1].
• In all patients admitted to our hospital with signs of acute gastrointestinal hemorrhage in whom Dieulafoy's disease was diagnosed at emergency endoscopy, an attempt was made to stop the bleeding or to prevent further hemorrhage by local injection of polidocanol, or by bipolar electrocoagulation, or by a combination of both [2].
• These data suggest that although epinephrine injection may slow or temporarily stop bleeding, this modality is not as efficacious as injection with 1% polidocanol or absolute ethanol in inducing definitive vessel thrombosis [3].
• In contrast, absolute ethanol and 1% polidocanol caused tissue necrosis, ulceration, and vessel thrombosis, the former by acute dehydration and fixation of the tissue, the latter by acute edema and subsequent inflammation and sclerosis [3].
• Sclerotherapy was performed twice weekly using 1% polidocanol as the sclerosing agent until the varices were eradicated or well-covered by fibrous tissue [4].

Psychiatry related information on Dodecylnonaoxyethylene glycol monoether

• 6 months after treatment with Aethoxysklerol, a statistically significant lengthening of the distal latency period as well as a significant reduction of the compound potential amplitude could be observed [5].

High impact information on Dodecylnonaoxyethylene glycol monoether

• Sclerotherapy was administered with 1% polidocanol at 10-day intervals until obliteration of varices was achieved [6].
• After randomization, 43 patients received propranolol twice daily at a dose reducing the heart rate by 25%; 42 patients were treated with intravariceal and extravariceal injections of Polidocanol; 41 control patients received vitamin K orally as placebo [7].
• All patients received endoscopic injection sclerotherapy using 1:10,000 adrenaline and 1% polidocanol and were randomly assigned to receive omeprazole (40 mg orally) every 12 hours for 5 days or an identical-looking placebo [8].
• RLIP76 or one of its derived deletion mutants was expressed in Escherichia coli, and bacteria were lysed and extracted in buffer without or with the nonionic detergent polidocanol [9].
• The United States Food and Drug Administration halted a clinical phase 2 trial of a commercial preparation of polidocanol microfoam in 2003 because of concerns relating to possible gas embolism [10].

Chemical compound and disease context of Dodecylnonaoxyethylene glycol monoether

• The hemorrhages were treated with sclerotherapy by submucous injections of polidocanol (Ethoxysclerol) or phenol (5 percent) almond oil [11].
• This compound should be used to treat oesophageal varices by paravariceal injection in smaller doses than 5% ethanolamine oleate and 1% polidocanol [12].
• Tortuous veins and telangiectases on the chest of three patients were treated with either STS 0.25-0.50% or polidocanol 0.75% with a follow-up of 2-9 years [13].
• Efficacy of ethanolamine and polidocanol in the eradication of esophageal varices. A prospective randomized trial [14].
• Allergic contact dermatitis to polidocanol (Thesit) [15].

Biological context of Dodecylnonaoxyethylene glycol monoether

• Polidocanol may directly activate the contact phase of blood coagulation during sclerotherapy [16].
• After the first course, 88.8% of the patients in the laser group and 81.5% in the polidocanol group were able to swallow a normal oral caloric intake [17].
• Stomach wall slough and ulcer perforation following endoscopic injection hemostasis with polidocanol [18].
• At 0.3% polidocanol or 0.1% sodium tetradecyl sulfate, cell death occurred within 15 minutes [19].
• In the isolated papillary muscle, the sclerosing agent (dilution 1:10,000; polidocanol 1 x 10(-5) mol/l) decreased the maximum rate of rise of the action potential and shortened its duration, both by about 10% [20].

Anatomical context of Dodecylnonaoxyethylene glycol monoether

• Treatment of hydrocele testis with aspiration and injection of polidocanol [21].
• Polidocanol was instilled in five pleural cavities of three pigs [22].
• In the short-term perspective, sclerosing polidocanol injections targeting the neovessels in the supraspinatus tendon and/or bursa wall seems to have a potential to reduce the pain during shoulder loading activity [23].
• Bleeding varices of the esophagus were sclerosed transendoscopically intravenously using 1% polidocanol solution [24].
• Evaluation of the efficacy of polidocanol in the form of foam compared with liquid form in sclerotherapy of the greater saphenous vein: initial results [25].

Associations of Dodecylnonaoxyethylene glycol monoether with other chemical compounds

• After endoscopic therapy (injection of epinephrine and polidocanol), patients were randomized to outpatient or hospital care [26].
• METHODS: Sclerotherapy was performed using ethanolamine and polidocanol injection at 1, 2, and 3 weeks and every 3 weeks thereafter [27].
• Seventeen patients (23 knees) were randomized to the treatment group (polidocanol injections in the area of neovascularization) and 16 patients (20 knees) to the control group (similar injections with lidocaine/epinephrine) [28].
• METHODS: In the present study, the effect on the endothelium and the haemolytic and thrombosing effects of XZL were compared with those of 5% ethanolamine oleate and 1% polidocanol, using an endothelial cell line and red blood cells taken from rats and the dorsal marginal ear vein of rabbits [12].
• BACKGROUND AND STUDY AIMS: N-2-cyanoacrylate (Histoacryl) and endoscopic sclerotherapy with polidocanol have both been reported to control variceal bleeding [29].

Gene context of Dodecylnonaoxyethylene glycol monoether

• Thirteen cirrhotic patients received intravenous alimentation for 2 to 17 days, 8 were given somatostatin for variceal bleeding, and 7 have previously had 1 to 5 sessions of endoscopic sclerotherapy of esophageal varices with polidocanol [30].
• Acid gastroesophageal reflux was determined by long-term pH monitoring in 19 consecutive variceal bleeders after 5 to 20 (mean, 10.3 +/- 1 SEM) sclerotherapy sessions with the flexible endoscope using polidocanol 1% as sclerosant [31].
• METHOD: Prospective study with 100 patients (120 legs) with primary varicose veins, which are treated with polidocanol as sclerosant with the empty vein technique [32].
• The animals underwent five weekly sessions of sclerotherapy with polidocanol 2% and were concomitantly treated with either placebo or EGF administered either paravenously or subcutaneously [33].
• Treatment of aneurysmal bone cysts with percutaneous sclerotherapy using polidocanol: A REVIEW OF 72 CASES WITH LONG-TERM FOLLOW-UP [34].

Analytical, diagnostic and therapeutic context of Dodecylnonaoxyethylene glycol monoether

• Sclerotherapy was performed weekly with 1% polidocanol, and variceal obliteration was obtained in 83% of cases, in a mean number of four sessions [35].
• Pleurodesis with polidocanol in pigs. An experimental study [22].
• After 8 months, when the control group had also received active treatment with polidocanol, they had a greater improvement in Victorian Institute of Sport Assessment score (58-79) than did the treatment group (54-70; group by time interaction, P = .022; time effect, P < .0001) [28].
• IEIS was performed during emergency fiberoptic endoscopy applying 5-40 1-ml injections of 0.5% polidocanol by the paravariceal, "free" injection technique [36].
• Polidocanol has been widely used but local complications have been reported after treatment [37].

References