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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cefadroxil compared with cefaclor in the treatment of streptococcal pneumonia in adults.

103 young male Black African gold-miners with pneumococcal pneumonia confirmed by culture or serology were randomly assigned to receive the long acting oral cephalosporin cefadroxil 1 g every 12 hours or cefaclor 500 mg every 8 hours for 10 days. Clinical cures were obtained in 94% of the group who received cefadroxil and in 94% of the cefaclor group. Similarly, the causative organism S. pneumoniae was eradicated in 98% and 96% of patients who received cefadroxil and cefaclor, respectively. Minimal side effects occurred in both groups, although 1 patient withdrew from therapy with cefaclor because of severe diarrhoea. Thus, cefadroxil and cefaclor both displayed effective antimicrobial activity with low toxicity in the treatment of pneumococcal pneumonia.[1]


  1. Cefadroxil compared with cefaclor in the treatment of streptococcal pneumonia in adults. ZeLuff, B., Catchpole, M., Lowe, P., Koornhof, H., Gentry, L. Drugs (1986) [Pubmed]
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