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Chemical Compound Review

Ultracef     (6R,7S)-7-[[(2R)-2-amino-2- (4...

Synonyms: Duricef, cefadroxil, Cefadroxilo, Cephadroxil, Cefadroxilum, ...
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Disease relevance of cefadroxil


Psychiatry related information on cefadroxil

  • These characteristics permit the administration of cefadroxil during meals on a once-daily or twice-daily basis, thus encouraging patient compliance which often determines the successful management of out-patient infections [5].

High impact information on cefadroxil

  • A single clone (rPepT2) was isolated that stimulated cefadroxil uptake into oocytes approximately 70-fold at a pH of 6 [6].
  • Injection of poly(A)+ RNA isolated from rabbit kidney cortex into oocytes resulted in expression of a pH-dependent transport activity for the aminocephalosporin antibiotic cefadroxil [6].
  • Cyclacillin was 9-fold more potent than cefadroxil in competing with glycylsacosine for uptake via PEPT 1 [7].
  • In contrast, cefadroxil was 13-fold more potent than cyclacillin in competing with the dipeptide for uptake via PEPT 2 [7].
  • Kinetic parameters and bioavailability of cefadroxil were studied in 20 subjects with differing renal function as measured by endogenous creatinine clearance (CCr) [2].

Chemical compound and disease context of cefadroxil


Biological context of cefadroxil


Anatomical context of cefadroxil

  • Cefadroxil was given as a suspension in a daily dose of 30 to 50 mg/kg in 2 divided doses every 12 hours to all but 76 patients; 50 patients with acute otitis media were given 100 mg/kg/day in 2 doses and 26 patients with urinary tract infections received 25 mg/day once daily [16].
  • Penetration and concentration of cefadroxil in sputum, lung and pleural fluid [14].
  • Transport of cefadroxil, an aminocephalosporin antibiotic, across the small intestinal brush border membrane [17].
  • These findings demonstrate that PEPT2 is the primary transporter responsible for cefadroxil uptake in the choroid plexus [18].
  • The transport characteristics of cefadroxil, an aminocephalosporin antibiotic, across the brush border membrane of rat small intestine were investigated by a rapid filtration technique [17].

Associations of cefadroxil with other chemical compounds


Gene context of cefadroxil

  • The pathogen eradication rate for MRSA was 92.3 and 85.7% in the linezolid and cefadroxil groups, respectively (P = 0.64) [22].
  • Ten days of cefadroxil therapy was used to treat 44 children with urinary tract infection and CRP values greater than or equal to 28 microgram/ml (CRP-positive group) [23].
  • The influence of cefadroxil on LTB4-receptor expression of polymorphonuclear leucocytes (PMNs) was studied [24].
  • Amoxicillin and cefadroxil, the internal standard, were extracted from 50-200 microliters of sample with Bond Elut C18 cartridges [25].
  • Amongst the zwitterionic cephalosporins, which all inhibit PAH transport, the amino cephalosporin analogue cefadroxil was identified to interact also with NMeN transport (Ki,PAH = 3.0, Ki,NMeN = 11.2 mmol/l) [26].

Analytical, diagnostic and therapeutic context of cefadroxil


  1. Double-blind randomized study of oral temafloxacin and cefadroxil in patients with mild to moderately severe bacterial skin infections. Neldner, K.H. Am. J. Med. (1991) [Pubmed]
  2. Cefadroxil kinetics in patients with renal insufficiency. Cutler, R.E., Blair, A.D., Kelly, M.R. Clin. Pharmacol. Ther. (1979) [Pubmed]
  3. Randomized, single-blind evaluation of cefadroxil and phenoxymethyl penicillin in the treatment of streptococcal pharyngitis. Pichichero, M.E., Disney, F.A., Aronovitz, G.H., Talpey, W.B., Green, J.L., Francis, A.B. Antimicrob. Agents Chemother. (1987) [Pubmed]
  4. Efficacy of a twice-daily regimen of cefadroxil in the treatment of respiratory tract infections. Quintiliani, R. Drugs (1986) [Pubmed]
  5. Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine. Tanrisever, B., Santella, P.J. Drugs (1986) [Pubmed]
  6. Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Boll, M., Herget, M., Wagener, M., Weber, W.M., Markovich, D., Biber, J., Clauss, W., Murer, H., Daniel, H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. Ganapathy, M.E., Brandsch, M., Prasad, P.D., Ganapathy, V., Leibach, F.H. J. Biol. Chem. (1995) [Pubmed]
  8. Comparison of cefadroxil and cephalexin in the treatment of community-acquired pneumonia. Blaser, M.J., Klaus, B.D., Jacobson, J.A., Kasworm, E., LaForce, F.M. Antimicrob. Agents Chemother. (1983) [Pubmed]
  9. A comparison of cefadroxil and penicillin V in the treatment of streptococcal pharyngitis in children. Gerber, M.A. Drugs (1986) [Pubmed]
  10. Cefadroxil compared with cefaclor in the treatment of streptococcal pneumonia in adults. ZeLuff, B., Catchpole, M., Lowe, P., Koornhof, H., Gentry, L. Drugs (1986) [Pubmed]
  11. A comparative study of cefadroxil and co-trimoxazole in patients with lower respiratory tract infections. Castro, M. Drugs (1986) [Pubmed]
  12. Pharmacokinetics of cefadroxil after oral administration in humans. La Rosa, F., Ripa, S., Prenna, M., Ghezzi, A., Pfeffer, M. Antimicrob. Agents Chemother. (1982) [Pubmed]
  13. Clinical pharmacology of cefadroxil in infants and children. Ginsburg, C.M., McCracken, G.H., Clahsen, J.C., Thomas, M.L. Antimicrob. Agents Chemother. (1978) [Pubmed]
  14. Penetration and concentration of cefadroxil in sputum, lung and pleural fluid. Nightingale, C.H. Drugs (1986) [Pubmed]
  15. Transport of cefadroxil in rat kidney brush-border membranes is mediated by two electrogenic H+-coupled systems. Ries, M., Wenzel, U., Daniel, H. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  16. Cefadroxil in the treatment of susceptible infections in infants and children. Puhakka, H., Virolainen, E. Drugs (1986) [Pubmed]
  17. Transport of cefadroxil, an aminocephalosporin antibiotic, across the small intestinal brush border membrane. Kimura, T., Yamamoto, T., Ishizuka, R., Sezaki, H. Biochem. Pharmacol. (1985) [Pubmed]
  18. Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice. Ocheltree, S.M., Shen, H., Hu, Y., Xiang, J., Keep, R.F., Smith, D.E. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  19. Pharmacokinetics of cefadroxil and cefaclor during an eight-day dosage period. Hampel, B., Lode, H., Wagner, J., Koeppe, P. Antimicrob. Agents Chemother. (1982) [Pubmed]
  20. Comparative in-vitro activity of a new oral carbacephem, LY163892. Howard, A.J., Dunkin, K.T. J. Antimicrob. Chemother. (1988) [Pubmed]
  21. Comparative pharmacokinetics of cefadroxil, cefaclor, cephalexin and cephradine in infants and children. Ginsburg, C.M. J. Antimicrob. Chemother. (1982) [Pubmed]
  22. Linezolid for the treatment of methicillin-resistant Staphylococcus aureus infections in children. Kaplan, S.L., Afghani, B., Lopez, P., Wu, E., Fleishaker, D., Edge-Padbury, B., Naberhuis-Stehouwer, S., Bruss, J.B. Pediatr. Infect. Dis. J. (2003) [Pubmed]
  23. Evaluation of short-term antibiotic therapy in children with uncomplicated urinary tract infections. McCracken, G.H., Ginsburg, C.M., Namasonthi, V., Petruska, M. Pediatrics (1981) [Pubmed]
  24. In-vitro enhancement of leukotriene B4 receptor expression on human neutrophils by cefadroxil. Knöller, J., Brom, J., Schönfeld, W., König, W. J. Antimicrob. Chemother. (1990) [Pubmed]
  25. Sensitive assay for measuring amoxicillin in human plasma and middle ear fluid using solid-phase extraction and reversed-phase high-performance liquid chromatography. Yuan, Z., Russlie, H.Q., Canafax, D.M. J. Chromatogr. B, Biomed. Appl. (1995) [Pubmed]
  26. Bisubstrates: substances that interact with both, renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; nonionizable substrates: steroid hormones and cyclophosphamides. Ullrich, K.J., Rumrich, G., David, C., Fritzsch, G. Pflugers Arch. (1993) [Pubmed]
  27. Analysis of cefadroxil by micellar electrokinetic capillary chromatography: development and validation. Li, Y.M., Vanderghinste, D., Pecanac, D., Van Schepdael, A., Roets, E., Hoogmartens, J. Electrophoresis (1998) [Pubmed]
  28. The in-vitro activity of cefadroxil, and the interpretation of disc-susceptibility testing. Casewell, M.W., Bragman, S.G. J. Antimicrob. Chemother. (1987) [Pubmed]
  29. Column liquid chromatography and microbiological assay compared for determination of cefadroxil preparations. Hsu, M.C., Chang, Y.W., Lee, Y.T. J. Chromatogr. (1992) [Pubmed]
  30. Therapy for pharyngitis and tonsillitis caused by group A beta-hemolytic streptococci: a meta-analysis comparing the efficacy and safety of cefadroxil monohydrate versus oral penicillin V. Deeter, R.G., Kalman, D.L., Rogan, M.P., Chow, S.C. Clinical therapeutics. (1992) [Pubmed]
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