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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Two cases of lymphosarcoma in channel catfish exposed to N-methyl-N'-nitro-N-nitrosoguanidine.

Of 158 channel catfish (Ictalurus punctatus) exposed to N-methyl-N'-nitro-N-nitrosoguanidine [(MNNG) CAS:70-25-7] in water for 28 days, 2 developed disseminated lymphosarcoma. One fish was necropsied at 12 months and another at 18 months following exposure. Both fish had a massive neoplastic infiltration of the bilateral pairs of head and trunk kidneys from which the neoplastic cells appeared to originate. The neoplastic infiltration was also observed in the following: thymus, gills, oral mucosa, liver, skin, skeletal muscle of head-neck region, and to a lesser extent spleen and bone marrow. This is probably the first report of lymphosarcoma in channel catfish. Although the occurrence of lymphosarcoma in these 2 catfish appeared to be related to exposure to MNNG, the exact role MNNG played in the tumor formation was not determined.[1]


  1. Two cases of lymphosarcoma in channel catfish exposed to N-methyl-N'-nitro-N-nitrosoguanidine. Chen, H.H., Brittelli, M.R., Muska, C.F. J. Natl. Cancer Inst. (1985) [Pubmed]
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