The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Disposition of acetaminophen in protein-calorie malnutrition.

The influence of dietary protein deficiency on the pharmacokinetics, metabolism and disposition of acetaminophen was investigated in male Sprague-Dawley rats fed for 4 weeks on a 23% (control) or a 5% (low) protein diet ad libitum. Acetaminophen and its two major metabolites, acetaminophen glucuronide and acetaminophen sulfate in plasma and urine, were determined by a sensitive and specific high-performance liquid chromatography assay. After an i.v. dose of 100 mg/kg of acetaminophen, the average mean residence time was 40% higher in the protein-deficient rats, whereas the total plasma clearance per kilogram of body weight and elimination rate constant were both decreased by approximately 36% when compared to rats on a normal protein diet. No significant differences were found in the two groups of animals with respect to the apparent steady-state volume of distribution. Rats on a low protein diet excreted a larger percentage of the administered dose as the glucuronide conjugate (34.6 vs. 12.3%) and a smaller percentage as acetaminophen sulfate (41.0 vs. 70.1%). In addition, there was a reduction in the partial metabolic clearance to acetaminophen sulfate and a concomitant 2-fold increase in the partial metabolic clearance to acetaminophen glucuronide.[1]


  1. Disposition of acetaminophen in protein-calorie malnutrition. Jung, D. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
WikiGenes - Universities