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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Queuosine metabolism: possible relation to B-cell activation by C8 derivatives of guanosine.

The observed enhancement of B-lymphocyte activation by 8-bromoguanosine and 8-mercaptoguanosine is hypothesized to occur via a "binding protein" which requires a guanine nucleoside as the syn conformer for productive interaction. In addition, because of the 7-substituent, Q nucleoside also is hypothesized to bind as the syn conformer and, therefore, to be a potential B-lymphocyte activator.[1]

References

  1. Queuosine metabolism: possible relation to B-cell activation by C8 derivatives of guanosine. Katze, J.R. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
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