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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Allopurinol hypersensitivity syndrome as a cause of hepatic fibrin-ring granulomas.

Hepatic fibrin-ring granulomas were found in a 35-yr-old man who developed fever, myalgias, rash, eosinophilia, and abnormal liver function tests 4 wk after the beginning of allopurinol treatment. All clinical and biochemical abnormalities spontaneously resolved within 6 wk after cessation of therapy. There was no evidence for Q fever or Hodgkin's disease, which are the recognized causes of hepatic fibrin-ring granulomas. It is suggested that allopurinol hypersensitivity might be an additional cause of these peculiar granulomas.[1]

References

  1. Allopurinol hypersensitivity syndrome as a cause of hepatic fibrin-ring granulomas. Vanderstigel, M., Zafrani, E.S., Lejonc, J.L., Schaeffer, A., Portos, J.L. Gastroenterology (1986) [Pubmed]
 
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