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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Q Fever

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Disease relevance of Q Fever


High impact information on Q Fever

  • Sera from a blood-donor bank (n = 925) and from HIV-positive individuals selected at random, irrespective of clinical or immunological status (n = 500) were tested for Q fever [6].
  • The incidence rate of acute Q fever detection at the NRC was 0.58 per 100,000 inhabitants over the 9-year period [7].
  • Defective phagosome maturation and impaired C. burnetii killing were induced by adding interleukin (IL)-10 to monocytes from convalescent patients and were restored by IL-10 neutralization in chronic Q fever in evolution [8].
  • The recommended treatment for Q fever endocarditis is a combination of doxycycline and hydroxychloroquine [9].
  • Coxiella burnetii, the agent of Q fever, enters human monocytes through alpha(v)beta(3) integrin and survives inside host cells [10].

Chemical compound and disease context of Q Fever


Biological context of Q Fever

  • These experiments provide a basis for explaining the increased hepatic protein synthesis during Q fever and demonstrate, perhaps for the first time, the phosphorylation of ribosomal protein in response to lipopolysaccharide [16].

Anatomical context of Q Fever


Gene context of Q Fever


Analytical, diagnostic and therapeutic context of Q Fever


  1. Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine. Raoult, D., Houpikian, P., Tissot Dupont, H., Riss, J.M., Arditi-Djiane, J., Brouqui, P. Arch. Intern. Med. (1999) [Pubmed]
  2. Further characterization of a lipopolysaccharide from Coxiella burneti. Chan, M.L., McChesney, J., Paretsky, D. Infect. Immun. (1976) [Pubmed]
  3. Bacteriostatic and bactericidal activity of levofloxacin against Rickettsia rickettsii, Rickettsia conorii, 'Israeli spotted fever group rickettsia' and Coxiella burnetii. Maurin, M., Raoult, D. J. Antimicrob. Chemother. (1997) [Pubmed]
  4. Epstein-Barr virus infection and hepatic fibrin-ring granulomas. Nenert, M., Mavier, P., Dubuc, N., Deforges, L., Zafrani, E.S. Hum. Pathol. (1988) [Pubmed]
  5. Coxiella burnetii infection of aneurysms or vascular grafts: report of seven cases and review. Fournier, P.E., Casalta, J.P., Piquet, P., Tournigand, P., Branchereau, A., Raoult, D. Clin. Infect. Dis. (1998) [Pubmed]
  6. Q fever and HIV infection. Raoult, D., Levy, P.Y., Dupont, H.T., Chicheportiche, C., Tamalet, C., Gastaut, J.A., Salducci, J. AIDS (1993) [Pubmed]
  7. Epidemiologic features and clinical presentation of acute Q fever in hospitalized patients: 323 French cases. Tissot Dupont, H., Raoult, D., Brouqui, P., Janbon, F., Peyramond, D., Weiller, P.J., Chicheportiche, C., Nezri, M., Poirier, R. Am. J. Med. (1992) [Pubmed]
  8. Link between impaired maturation of phagosomes and defective Coxiella burnetii killing in patients with chronic Q fever. Ghigo, E., Honstettre, A., Capo, C., Gorvel, J.P., Raoult, D., Mege, J.L. J. Infect. Dis. (2004) [Pubmed]
  9. Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis. Rolain, J.M., Mallet, M.N., Raoult, D. J. Infect. Dis. (2003) [Pubmed]
  10. alpha(v)beta(3) integrin and bacterial lipopolysaccharide are involved in Coxiella burnetii-stimulated production of tumor necrosis factor by human monocytes. Dellacasagrande, J., Ghigo, E., Hammami, S.M., Toman, R., Raoult, D., Capo, C., Mege, J.L. Infect. Immun. (2000) [Pubmed]
  11. Antibiotic treatment in pneumonia due to Q fever. Sobradillo, V., Zalacain, R., Capelastegui, A., Uresandi, F., Corral, J. Thorax (1992) [Pubmed]
  12. In vivo response of acute Q fever to erythromycin. Ellis, M.E., Dunbar, E.M. Thorax (1982) [Pubmed]
  13. Susceptibility of Coxiella burnetii to pefloxacin and ofloxacin in ovo and in persistently infected L929 cells. Raoult, D., Yeaman, M.R., Baca, O.G. Antimicrob. Agents Chemother. (1989) [Pubmed]
  14. Prevalence, significance, and specificity of antibodies to phospholipids in Q fever. Ordi-Ros, J., Selva-O'Callaghan, A., Monegal-Ferran, F., Monasterio-Aspiri, Y., Juste-Sanchez, C., Vilardell-Tarres, M. Clin. Infect. Dis. (1994) [Pubmed]
  15. Q Fever pneumonia: are clarithromycin and moxifloxacin alternative treatments only? Morovic, M. Am. J. Trop. Med. Hyg. (2005) [Pubmed]
  16. Ribosomal protein phosphorylation induced during Q fever or by lipopolysaccharide: in vitro translation is stimulated by infected liver ribosomes. Hickey, M.J., Gonzales, F.R., Paretsky, D. Infect. Immun. (1985) [Pubmed]
  17. Fibrin ring granulomas in hepatitis A. Ruel, M., Sevestre, H., Henry-Biabaud, E., Courouce, A.M., Capron, J.P., Erlinger, S. Dig. Dis. Sci. (1992) [Pubmed]
  18. Q-fever and autoimmunity. Levy, P., Raoult, D., Razongles, J.J. Eur. J. Epidemiol. (1989) [Pubmed]
  19. Production of interleukin-10 and transforming growth factor beta by peripheral blood mononuclear cells in Q fever endocarditis. Capo, C., Zaffran, Y., Zugun, F., Houpikian, P., Raoult, D., Mege, J.L. Infect. Immun. (1996) [Pubmed]
  20. The 75-kD tumour necrosis factor (TNF) receptor is specifically up-regulated in monocytes during Q fever endocarditis. Ghigo, E., Capo, C., Amirayan, N., Raoult, D., Mege, J. Clin. Exp. Immunol. (2000) [Pubmed]
  21. Circulating cytokine balance and activation markers of leucocytes in Q fever. Capo, C., Amirayan, N., Ghigo, E., Raoult, D., Mege, J. Clin. Exp. Immunol. (1999) [Pubmed]
  22. Interleukin-4 induces Coxiella burnetii replication in human monocytes but not in macrophages. Ghigo, E., Imbert, G., Capo, C., Raoult, D., Mege, J.L. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  23. New criteria for immunofluorescence assay for Q fever diagnosis in Japan. Setiyono, A., Ogawa, M., Cai, Y., Shiga, S., Kishimoto, T., Kurane, I. J. Clin. Microbiol. (2005) [Pubmed]
  24. Livedo reticularis revealing a latent infective endocarditis due to Coxiella burnetti. Granel, B., Genty, I., Serratrice, J., Rey, J., Disdier, P., Raoult, D., Weiller, P.J. J. Am. Acad. Dermatol. (1999) [Pubmed]
  25. Host factors in the severity of Q fever. Raoult, D. Ann. N. Y. Acad. Sci. (1990) [Pubmed]
  26. Combined determination of Coxiella burnetii-specific immunoglobulin M (IgM) and IgA improves specificity in the diagnosis of acute Q fever. Devine, P., Doyle, C., Lambkin, G. Clin. Diagn. Lab. Immunol. (1997) [Pubmed]
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