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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of adrenalectomy on gamma-aminobutyric acid concentrations in the central nervous system.

Pyridoxal-5'-phosphate ( PLP) plays a crucial role in regulating the steady-state levels of gamma-aminobutyric acid (GABA) in CNS. Adrenalectomy resulted in decreased conversion of dietary vitamin B6 to PLP. As a consequence of this, GABA levels in cerebral cortex decrease, since synthesis of GABA is determined by glutamate decarboxylase, a PLP-dependent enzyme. Feeding diet supplemented with vitamin B6 elevated the GABA levels in adrenalectomized animals, because of increased availability of the coenzyme for apodecarboxylase. The data suggest a role for corticosteroids in maintaining GABA levels, through their effects on PLP formation.[1]

References

  1. Effect of adrenalectomy on gamma-aminobutyric acid concentrations in the central nervous system. David, S., Kalyankar, G.D. J. Neurochem. (1986) [Pubmed]
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