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Chemical Compound Review

Pyridoxamine-P     [4-(aminomethyl)-5-hydroxy-6- methyl...

Synonyms: SureCN43832, AGN-PC-00FC1S, AG-F-81248, CHEMBL1235353, CHEBI:18335, ...
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Disease relevance of PLP


Psychiatry related information on PLP


High impact information on PLP


Chemical compound and disease context of PLP


Biological context of PLP


Anatomical context of PLP


Associations of PLP with other chemical compounds


Gene context of PLP


Analytical, diagnostic and therapeutic context of PLP


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  2. Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism. Whyte, M.P., Mahuren, J.D., Vrabel, L.A., Coburn, S.P. J. Clin. Invest. (1985) [Pubmed]
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  5. Vitamin B6 deficiency in chronic liver disease--evidence for increased degradation of pyridoxal-5'-phosphate. Labadarios, D., Rossouw, J.E., McConnell, J.B., Davis, M., Williams, R. Gut (1977) [Pubmed]
  6. Biochemical and anthropometric evaluation of the nutritional status of 35-year-old Dutch men with reference to smoking and drinking habits. van Poppel, G., Schrijver, J., Meulmeester, J.F., Kempen-Voogd, N. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1989) [Pubmed]
  7. Evolution of catalytic and regulatory sites in phosphorylases. Palm, D., Goerl, R., Burger, K.J. Nature (1985) [Pubmed]
  8. Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. Whyte, M.P., Mahuren, J.D., Fedde, K.N., Cole, F.S., McCabe, E.R., Coburn, S.P. J. Clin. Invest. (1988) [Pubmed]
  9. Mucopolysaccharidosis type I subtypes. Presence of immunologically cross-reactive material and in vitro enhancement of the residual alpha-L-iduronidase activities. Schuchman, E.H., Desnick, R.J. J. Clin. Invest. (1988) [Pubmed]
  10. A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase. Berkovitch, F., Behshad, E., Tang, K.H., Enns, E.A., Frey, P.A., Drennan, C.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  11. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Robinson, K., Mayer, E.L., Miller, D.P., Green, R., van Lente, F., Gupta, A., Kottke-Marchant, K., Savon, S.R., Selhub, J., Nissen, S.E. Circulation (1995) [Pubmed]
  12. Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution. Momany, C., Ernst, S., Ghosh, R., Chang, N.L., Hackert, M.L. J. Mol. Biol. (1995) [Pubmed]
  13. Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate. Sivaraman, J., Li, Y., Larocque, R., Schrag, J.D., Cygler, M., Matte, A. J. Mol. Biol. (2001) [Pubmed]
  14. Cutaneous metabolism of vitamin B-6. Coburn, S.P., Slominski, A., Mahuren, J.D., Wortsman, J., Hessle, L., Millan, J.L. J. Invest. Dermatol. (2003) [Pubmed]
  15. Kinetic and structural characterization of Slr0077/SufS, the essential cysteine desulfurase from Synechocystis sp. PCC 6803. Tirupati, B., Vey, J.L., Drennan, C.L., Bollinger, J.M. Biochemistry (2004) [Pubmed]
  16. Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction. Karthikeyan, S., Zhou, Q., Zhao, Z., Kao, C.L., Tao, Z., Robinson, H., Liu, H.W., Zhang, H. Biochemistry (2004) [Pubmed]
  17. Two genes encoding 1-aminocyclopropane-1-carboxylate synthase in zucchini (Cucurbita pepo) are clustered and similar but differentially regulated. Huang, P.L., Parks, J.E., Rottmann, W.H., Theologis, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  18. The fasting B6 vitamer profile and response to a pyridoxine load in normal and cirrhotic subjects. Henderson, J.M., Codner, M.A., Hollins, B., Kutner, M.H., Merrill, A.H. Hepatology (1986) [Pubmed]
  19. Purification and characterization of glutamate decarboxylase from Neurospora crassa conidia. Hao, R., Schmit, J.C. J. Biol. Chem. (1991) [Pubmed]
  20. Some stereochemical features of aspartate beta-decarboxylase. Chang, C.C., Laghai, A., O'Leary, M.H., Floss, H.G. J. Biol. Chem. (1982) [Pubmed]
  21. A spectral probe near the subunit catalytic site of glutamine synthetase from Escherichia coli. Reduced pyridoxal 5'-phosphate.enzyme complexes. Whitley, E.J., Ginsburg, A. J. Biol. Chem. (1978) [Pubmed]
  22. The orientation of the major coat protein of bacteriophage f1 in the cytoplasmic membrane of Escherichia coli. Ohkawa, I., Webster, R.E. J. Biol. Chem. (1981) [Pubmed]
  23. Riboflavin and vitamin B-6 intakes and status and biochemical response to riboflavin supplementation in free-living elderly people. Madigan, S.M., Tracey, F., McNulty, H., Eaton-Evans, J., Coulter, J., McCartney, H., Strain, J.J. Am. J. Clin. Nutr. (1998) [Pubmed]
  24. Characterization of the estrogen receptor extracted from hen oviduct nuclei with pyridoxal phosphate. Seeley, D.H., Mester, J., Baulieu, E.E., Wolfson, A.J. Endocrinology (1984) [Pubmed]
  25. Transport and metabolism of pyridoxamine and pyridoxamine phosphate in the small intestine of the rat. Hamm, M.W., Mehansho, H., Henderson, L.M. J. Nutr. (1979) [Pubmed]
  26. Intestinal absorption of pyridoxal-5'-phosphate: disappearance from perfused segments of rat jejunum in vivo. Middleton, H.M. J. Nutr. (1979) [Pubmed]
  27. Effect of parenteral amino acid supplementation in alcoholic hepatitis. Diehl, A.M., Boitnott, J.K., Herlong, H.F., Potter, J.J., Van Duyn, M.A., Chandler, E., Mezey, E. Hepatology (1985) [Pubmed]
  28. Selective inactivation of pyridoxamine form of aspartate aminotransferase by iodoacetate. Carboxymethylation of 4'-amino group of bound pyridoxamine 5'-phosphate. Morino, Y., Okamoto, M., Tanase, S. J. Biol. Chem. (1978) [Pubmed]
  29. Effect of binding to hemoglobin and albumin on pyridoxal transport and metabolism. Ink, S.L., Henderson, L.M. J. Biol. Chem. (1984) [Pubmed]
  30. Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes. Fonda, M.L. J. Biol. Chem. (1992) [Pubmed]
  31. Nonstereospecific transamination catalyzed by pyridoxal phosphate-dependent amino acid racemases of broad substrate specificity. Lim, Y.H., Yoshimura, T., Kurokawa, Y., Esaki, N., Soda, K. J. Biol. Chem. (1998) [Pubmed]
  32. The redox behavior of the heme in cystathionine beta-synthase is sensitive to pH. Pazicni, S., Lukat-Rodgers, G.S., Oliveriusová, J., Rees, K.A., Parks, R.B., Clark, R.W., Rodgers, K.R., Kraus, J.P., Burstyn, J.N. Biochemistry (2004) [Pubmed]
  33. The human cDNA for a homologue of the plant enzyme 1-aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity. Koch, K.A., Capitani, G., Gruetter, M.G., Kirsch, J.F. Gene (2001) [Pubmed]
  34. Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase. Loubbardi, A., Marcireau, C., Karst, F., Guilloton, M. J. Bacteriol. (1995) [Pubmed]
  35. A structural gene (Hdc-s) for mouse kidney histidine decarboxylase. Martin, S.A., Bulfield, G. Biochem. Genet. (1984) [Pubmed]
  36. Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site. Kim, D.W., Yoon, C.S., Eum, W.S., Lee, B.R., An, J.J., Lee, S.H., Lee, S.R., Ahn, J.Y., Kwon, O.S., Kang, T.C., Won, M.H., Cho, S.W., Lee, K.S., Park, J., Choi, S.Y. Mol. Cells (2004) [Pubmed]
  37. Identification of amino acid residues modified by pyridoxal 5'-phosphate in Escherichia coli glutamine synthetase. Di Ianni, C.L., Villafranca, J.J. J. Biol. Chem. (1989) [Pubmed]
  38. Substitution of glutamine for lysine at the pyridoxal phosphate binding site of bacterial D-amino acid transaminase. Effects of exogenous amines on the slow formation of intermediates. Futaki, S., Ueno, H., Martinez del Pozo, A., Pospischil, M.A., Manning, J.M., Ringe, D., Stoddard, B., Tanizawa, K., Yoshimura, T., Soda, K. J. Biol. Chem. (1990) [Pubmed]
  39. Fluorine-19 as a covalent active site-directed magnetic resonance probe in aspartate transaminase. Martinez-Carrion, M., Slebe, J.C., Boettcher, B., Relimpio, A.M. J. Biol. Chem. (1976) [Pubmed]
  40. The measurement of plasma vitamin B6 compounds: comparison of a cation-exchange HPLC method with the open-column chromatographic method and the L-tyrosine apodecarboxylase assay. Lui, A., Lumeng, L., Li, T.K. Am. J. Clin. Nutr. (1985) [Pubmed]
  41. Plasma pyridoxal-5'-phosphate levels and clinical correlations in chronic hemodialysis patients. Teehan, B.P., Smith, L.J., Sigler, M.H., Gilgore, G.S., Schleifer, C.R. Am. J. Clin. Nutr. (1978) [Pubmed]
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