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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Continuous infusion epidural analgesia in obstetrics. A comparison of 0.08% and 0.25% bupivacaine.

The effects of 0.08% (Group A) and 0.25% (Group B) solutions of bupivacaine were compared in a random manner, to assess continuous pump infusion epidural analgesia in labour. Both solutions were infused at a dose rate of 20 mg bupivacaine/hour. The results in all the mothers who had received infusions lasting more than 4 hours were studied. There were 25 in Group A and 28 in Group B. Any treatment during the infusion epidural for inadequate analgesia, hypotension, etc., was recorded as an intervention. The mean of the intervention-free intervals was significantly greater in Group A than in Group B, and significantly fewer top-up injections were required in Group A. The results show that the administration of a 0.08% solution of bupivacaine into the epidural space by continuous pump infusion is more labour saving than the infusion of a 0.25% solution. The concept that a greater volume infusion rate maintains a more extended liquid sleeve of local anaesthetic in the epidural space is supported.[1]


  1. Continuous infusion epidural analgesia in obstetrics. A comparison of 0.08% and 0.25% bupivacaine. Ewen, A., McLeod, D.D., MacLeod, D.M., Campbell, A., Tunstall, M.E. Anaesthesia. (1986) [Pubmed]
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