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MeSH Review

Infusion Pumps

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Disease relevance of Infusion Pumps


Psychiatry related information on Infusion Pumps


High impact information on Infusion Pumps

  • Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump [7].
  • In the first study, either ranitidine or placebo was administered IV by a pH-feedback-controlled infusion pump during fasting, modified sham feeding, or food ingestion [8].
  • The wearable artificial endocrine pancreas, incorporating the needle-type glucose sensor, a computer calculating infusion rates of insulin, glucagon, or both, and infusion pumps, was tested in pancreatectomised dogs: the device produced perfect control of blood glucose for up to 7 days [9].
  • INTERVENTION: Continuous intravenous prostacyclin administered by portable infusion pump on a compassionate-use basis [10].
  • The reversibility of cytokine-induced effects was determined either by removal of the osmotic infusion pumps on day 15 or by treatment of the animals with a soluble TNF-alpha antagonist (TNFR:Fc) [11].

Chemical compound and disease context of Infusion Pumps


Biological context of Infusion Pumps

  • Improvement of glucose homeostasis in insulin-dependent diabetics using a miniature insulin infusion pump with a fixed profile [17].
  • An open one-compartment mathematical model developed in this study was used to estimate the decreasing doses administered with a computer-controlled infusion pump that simulated in rabbits the human serum pharmacokinetics after intravenous administration of 2 g of ampicillin every 4 h [18].
  • OBJECTIVE: To determine whether variations in the flow rate of epinephrine solutions administered via commonly available infusion pumps lead to significant variations in blood pressure (BP) in vivo [19].
  • According to the nurses, the mean time (+/- SD) required to become comfortable using the Pharmacia Deltec CADD-PCA was significantly longer (50 +/- 37 min) than that using the Abbott Lifecare Plus (19 +/- 17 min), Bard PCA I (17 +/- 14 min), IVAC PCA (17 +/- 14 min), or Baxter PCA Infusor (7 +/- 8 min) [20].
  • We conclude that after moderately painful orthopedic surgery of the shoulder, ropivacaine infusion using a portable infusion pump and an interscalene perineural catheter at home decreased pain, opioid use and related side effects, and sleep disturbances [21].

Anatomical context of Infusion Pumps

  • The results of this study show that a continuous infusion of TNF-alpha led to a time-dependent depression in LV function, cardiac myocyte shortening, and LV dilation that were at least partially reversible by removal of the osmotic infusion pumps or treatment of the animals with TNFR:Fc [11].
  • IL-2 (45,000 Japanese reference units [JRU]/d) or saline was administered continuously via the portal vein immediately after hepatectomy using an infusion pump [22].
  • Four days after the removal of the infusion pumps, rats were killed and the pancreas harvested to study the mechanism by which GLP-1 ameliorated glucose tolerance [23].
  • We used a computer-controlled infusion pump (CCIP) to target and maintain stable plasma lidocaine concentrations and study the effect of intravenous lidocaine on (1) pain scores, (2) current perception thresholds, (3) side effects, and (4) pain distribution in patients suffering from peripheral nerve injury pain [24].
  • The goal of this investigation was to use a computer-controlled infusion pump (CCIP) to obtain constant serum thiopental concentrations and use the electroencephalogram (EEG) as a measure of thiopental's central nervous system drug effect [25].

Associations of Infusion Pumps with chemical compounds

  • An alternative method to overcome central venous portable external infusion pump blockage in patients receiving weekly 24-hour high-dose fluorouracil and leucovorin [26].
  • They were given propofol with a computer-controlled infusion pump to achieve three stable levels of plasma concentrations corresponding to mild sedation, deep sedation, and unconsciousness, the latter defined as unresponsiveness to verbal commands [27].
  • Next, unilateral chronic injection cannulae connected to an Alzet infusion pump filled with the GABA synthesis inhibitor L-allylglycine (L-AG) were implanted into the DMH [28].
  • The drug was delivered via a tunneled subclavian catheter by a portable infusion pump (Cormed model ML-6) primed to provide a volume of diluted drug of 10 cc/day [29].
  • Since administration of diet and ethanol (or isocaloric glucose solution) is precisely controlled by infusion pumps, this system makes unnecessary the measurement of diet consumption that has to be done daily for each animal with other methods.(ABSTRACT TRUNCATED AT 250 WORDS)[30]

Gene context of Infusion Pumps


Analytical, diagnostic and therapeutic context of Infusion Pumps


  1. Avoidance of gastroduodenal toxicity in patients receiving hepatic arterial 5-fluoro-2'-deoxyuridine. Hohn, D.C., Stagg, R.J., Price, D.C., Lewis, B.J. J. Clin. Oncol. (1985) [Pubmed]
  2. Lack of glucagon response to hypoglycemia in type I diabetics after long-term optimal therapy with a continuous subcutaneous insulin infusion pump. Bergenstal, R.M., Polonsky, K.S., Pons, G., Jaspan, J.B., Rubenstein, A.H. Diabetes (1983) [Pubmed]
  3. Maintenance of intragastric pH > 4 with famotidine in duodenal ulcer patients: factors influencing drug requirements. Delchier, J.C., Roudot-Thoraval, F., Stanescu, L., Deharvengt, M.C., Elouaer Blanc, L. Gut (1994) [Pubmed]
  4. Suppression of follicular maturation by infusion of a luteinizing hormone-releasing hormone agonist starting during the late luteal phase in the stumptailed macaque monkey. Fraser, H.M., Sandow, J. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  5. Stimulation of liver regeneration and function after partial hepatectomy in cirrhotic rats by continuous infusion of recombinant human hepatocyte growth factor. Kaibori, M., Kwon, A.H., Nakagawa, M., Wei, T., Uetsuji, S., Kamiyama, Y., Okumura, T., Kitamura, N. J. Hepatol. (1997) [Pubmed]
  6. Ambulatory 4-day continuous-infusion schedule of high-dose ifosfamide with mesna uroprotection and granulocyte colony-stimulating factor in advanced solid tumours: a phase I study. Toma, S., Palumbo, R., Comandone, A., Oliva, C., Vincenti, M., Bumma, C., Rosso, R. Ann. Oncol. (1995) [Pubmed]
  7. Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump. Tamborlane, W.V., Sherwin, R.S., Genel, M., Felig, P. N. Engl. J. Med. (1979) [Pubmed]
  8. The cephalic and gastric phases of gastric secretion during H2-antagonist treatment. Merki, H.S., Wilder-Smith, C.H., Walt, R.P., Halter, F. Gastroenterology (1991) [Pubmed]
  9. Wearable artificial endocrine pancrease with needle-type glucose sensor. Shichiri, M., Kawamori, R., Yamasaki, Y., Hakui, N., Abe, H. Lancet (1982) [Pubmed]
  10. Compassionate use of continuous prostacyclin in the management of secondary pulmonary hypertension: a case series. McLaughlin, V.V., Genthner, D.E., Panella, M.M., Hess, D.M., Rich, S. Ann. Intern. Med. (1999) [Pubmed]
  11. Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. Bozkurt, B., Kribbs, S.B., Clubb, F.J., Michael, L.H., Didenko, V.V., Hornsby, P.J., Seta, Y., Oral, H., Spinale, F.G., Mann, D.L. Circulation (1998) [Pubmed]
  12. A model of the ventilatory depressant potency of remifentanil in the non-steady state. Bouillon, T., Bruhn, J., Radu-Radulescu, L., Andresen, C., Cohane, C., Shafer, S.L. Anesthesiology (2003) [Pubmed]
  13. Reduced food intake in zinc deficient rats is normalized by megestrol acetate but not by insulin-like growth factor-I. Browning, J.D., MacDonald, R.S., Thornton, W.H., O'Dell, B.L. J. Nutr. (1998) [Pubmed]
  14. Phase I study of 5-fluorouracil and leucovorin by a 14-day circadian infusion in metastatic adenocarcinoma patients. Bjarnason, G.A., Kerr, I.G., Doyle, N., Macdonald, M., Sone, M. Cancer Chemother. Pharmacol. (1993) [Pubmed]
  15. Improved pain management outcomes with continuous infusion of a local anesthetic after thoracotomy. Wheatley, G.H., Rosenbaum, D.H., Paul, M.C., Dine, A.P., Wait, M.A., Meyer, D.M., Jessen, M.E., Ring, W.S., DiMaio, J.M. J. Thorac. Cardiovasc. Surg. (2005) [Pubmed]
  16. Continuous intrathecal pump infusion of baclofen with antibiotic drugs for treatment of pump-associated meningitis. Case report. Zed, P.J., Stiver, H.G., Devonshire, V., Jewesson, P.J., Marra, F. J. Neurosurg. (2000) [Pubmed]
  17. Improvement of glucose homeostasis in insulin-dependent diabetics using a miniature insulin infusion pump with a fixed profile. Køolendorf, K., Bojsen, J., Løorup, B. Diabetologia (1980) [Pubmed]
  18. Treatment of experimental endocarditis due to Enterococcus faecalis using once-daily dosing regimen of gentamicin plus simulated profiles of ampicillin in human serum. Gavaldà, J., Cardona, P.J., Almirante, B., Capdevila, J.A., Laguarda, M., Pou, L., Crespo, E., Pigrau, C., Pahissa, A. Antimicrob. Agents Chemother. (1996) [Pubmed]
  19. Influence of infusion pump operation and flow rate on hemodynamic stability during epinephrine infusion. Klem, S.A., Farrington, J.M., Leff, R.D. Crit. Care Med. (1993) [Pubmed]
  20. Patient and nurse evaluation of patient-controlled analgesia delivery systems for postoperative pain management. Sawaki, Y., Parker, R.K., White, P.F. Journal of pain and symptom management. (1992) [Pubmed]
  21. Continuous interscalene brachial plexus block for postoperative pain control at home: a randomized, double-blinded, placebo-controlled study. Ilfeld, B.M., Morey, T.E., Wright, T.W., Chidgey, L.K., Enneking, F.K. Anesth. Analg. (2003) [Pubmed]
  22. Influence of continuous interleukin-2 administration via the portal vein on liver regeneration following partial hepatectomy in rats. Wadamori, K., Oka, M., Tokuda, N., Fujikura, Y., Hazama, S., Fukumoto, T., Suzuki, T. Hepatology (1996) [Pubmed]
  23. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Farilla, L., Hui, H., Bertolotto, C., Kang, E., Bulotta, A., Di Mario, U., Perfetti, R. Endocrinology (2002) [Pubmed]
  24. Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. Wallace, M.S., Dyck, J.B., Rossi, S.S., Yaksh, T.L. Pain (1996) [Pubmed]
  25. Thiopental pharmacodynamics. I. Defining the pseudo-steady-state serum concentration-EEG effect relationship. Bührer, M., Maitre, P.O., Hung, O.R., Ebling, W.F., Shafer, S.L., Stanski, D.R. Anesthesiology (1992) [Pubmed]
  26. An alternative method to overcome central venous portable external infusion pump blockage in patients receiving weekly 24-hour high-dose fluorouracil and leucovorin. Yeh, K.H., Cheng, A.L. J. Clin. Oncol. (1994) [Pubmed]
  27. Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study. Fiset, P., Paus, T., Daloze, T., Plourde, G., Meuret, P., Bonhomme, V., Hajj-Ali, N., Backman, S.B., Evans, A.C. J. Neurosci. (1999) [Pubmed]
  28. The circumventricular organs form a potential neural pathway for lactate sensitivity: implications for panic disorder. Shekhar, A., Keim, S.R. J. Neurosci. (1997) [Pubmed]
  29. Constant infusion schedule for adriamycin: a phase I-II clinical trial of a 30-day schedule by ambulatory pump delivery system. Lokich, J., Bothe, A., Zipoli, T., Green, R., Sonneborn, H., Paul, S., Philips, D. J. Clin. Oncol. (1983) [Pubmed]
  30. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Tsukamoto, H., Gaal, K., French, S.W. Hepatology (1990) [Pubmed]
  31. Plasma concentration of prolactin during four-day osmotic pump infusion of thyrotropin-releasing hormone and vasoactive intestinal polypeptide in rats. Niimi, M., Takahara, J., Kawanishi, K. Endocrinol. Jpn. (1985) [Pubmed]
  32. Paradoxical growth-promoting effects induced by patterned infusions of somatostatin in female rats. Clark, R.G., Robinson, I.C. Endocrinology (1988) [Pubmed]
  33. Endocrine predictors of acute hemodynamic effects of growth hormone in congestive heart failure. Giustina, A., Volterrani, M., Manelli, F., Desenzani, P., Poiesi, C., Lorusso, R., Giordano, A. Am. Heart J. (1999) [Pubmed]
  34. A comparison of the effect of levodopa and somatostatin on the plasma levels of growth hormone, insulin, glucagon and prolactin in acromegaly. Dunn, P.J., Donald, R.A., Espiner, E.A. Clin. Endocrinol. (Oxf) (1976) [Pubmed]
  35. Alpha-synuclein-positive structures induced in leupeptin-infused rats. Nakajima, T., Takauchi, S., Ohara, K., Kokai, M., Nishii, R., Maeda, S., Takanaga, A., Tanaka, T., Takeda, M., Seki, M., Morita, Y. Brain Res. (2005) [Pubmed]
  36. Reducing costs and hospital stay for pneumonia with home intravenous cefotaxime treatment: results with a computerized ambulatory drug delivery system. Williams, D.N. Am. J. Med. (1994) [Pubmed]
  37. Persistent hyperinsulinemic hypoglycemia of infancy: long-term octreotide treatment without pancreatectomy. Glaser, B., Hirsch, H.J., Landau, H. J. Pediatr. (1993) [Pubmed]
  38. Vaporizer for volatile anesthetics during high-frequency jet ventilation. Mazloomdoost, M., Klain, M., Nemoto, E.M., Lin, M.R., Lee-Foon, W. Anesthesiology (1989) [Pubmed]
  39. Continuous subcutaneous insulin therapy during early pregnancy. Kitzmiller, J.L., Younger, M.D., Hare, J.W., Phillippe, M., Vignati, L., Fargnoli, B., Grause, A. Obstetrics and gynecology. (1985) [Pubmed]
  40. Continuous infusion epidural analgesia in obstetrics. A comparison of 0.08% and 0.25% bupivacaine. Ewen, A., McLeod, D.D., MacLeod, D.M., Campbell, A., Tunstall, M.E. Anaesthesia. (1986) [Pubmed]
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