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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genotoxicity of formaldehyde in cultured human bronchial fibroblasts.

Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens.[1]


  1. Genotoxicity of formaldehyde in cultured human bronchial fibroblasts. Grafstrom, R.C., Curren, R.D., Yang, L.L., Harris, C.C. Science (1985) [Pubmed]
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