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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Iodine toxicity in a patient treated by continuous povidone-iodine mediastinal irrigation.

Continuous povidone-iodine irrigation is frequently used to treat mediastinitis after median sternotomy and has been considered safe and effective. We describe a 34-month-old patient with mediastinitis after median sternotomy who was treated with continuous povidone-iodine irrigation and who absorbed toxic quantities of iodine (total serum iodine, 9,375 micrograms/dl; normal range, 4.5 to 9.0 micrograms/dl). An unexplained metabolic acidosis developed, along with changes in mental status, and the patient died. This experience and a thorough review of the literature lead us to believe that continuous povidone-iodine irrigation of the mediastinum is contraindicated.[1]

References

  1. Iodine toxicity in a patient treated by continuous povidone-iodine mediastinal irrigation. Glick, P.L., Guglielmo, B.J., Tranbaugh, R.F., Turley, K. Ann. Thorac. Surg. (1985) [Pubmed]
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