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Chemical Compound Review

Kollidon     1-ethenylpyrrolidin-2-one

Synonyms: Periston, Plasdone, Povidone, Bolinan, Protagent, ...
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Disease relevance of Povidone


Psychiatry related information on Povidone


High impact information on Povidone


Chemical compound and disease context of Povidone


Biological context of Povidone


Anatomical context of Povidone

  • Effect of povidone-iodine on neonatal thyroid function [20].
  • Although the specific rate of uptake by parenchymal cells was always slower than that shown by both Kupffer and endothelial cells, the total contribution of parenchymal cells to the clearance of polyvinylpyrrolidone, antimony sulfur colloid, and heparin by the liver was even greater than that of the other two cell classes [16].
  • Bladder irrigation with povidone-iodine in prevention of urinary-tract infections associated with intermittent urethral catheterisation [21].
  • The higher rate of uptake was a consequence of the protein entering the cells chiefly by adsorption to the plasma membrane being internalized; 125I-labeled albumin did not stimualte, nor did 125I-labeled polyvinylpyrrolidone inhibit pinocytosis [22].
  • The wound did not heal after repeated debridement, closed irrigation of the mediastinum with povidone-iodine solution, and antimycoplasmal chemotherapy; muscle flap grafting was eventually required [23].

Associations of Povidone with other chemical compounds

  • Two patients, one 30 years old with a 75% burn, the second 72 years old with a 35% burn, were treated topically with povidone-iodine ("Betadine", pH 2.43) [24].
  • Colloidal gold coated with trypsin-digested nucleoplasmin (which lacks the polypeptide domain required for transport) or exogenous polyvinylpyrrolidone were largely excluded from the nucleus and showed no evidence of transport [25].
  • Pinocytic capture of 125I-labelled polyvinylpyrrolidone and of formaldehyde-denatured 125I-labelled bovine serum albumin by 17.5-day rat visceral yolk sacs incubated in vitro was rapidly and strongly inhibited by low concentrations (0.01 and 0.05%, v/v) of ethanol [26].
  • After immunizations with glucagon or vasopressin, either conjugated to keyhole limpet hemocyanin or adsorbed to polyvinylpyrrolidone, both anti-hormone and anti-receptor activities were detectable in the serum of injected mice [27].
  • Of these, 67 received skin disinfection at the venous catheter insertion site with povidone iodine (control group), and 69 received the same treatment followed by application of 2% mupirocin ointment at the cannula site after catheter placement and at the end of each dialysis session [28].

Gene context of Povidone

  • To evaluate the effects of exogenous prolactin (PRL) and endogenously secreted hGH on pituitary and Leydig cell function, adult male transgenic and nontransgenic mice (10-16 wk of age) were treated s.c. with either saline-polyvinylpyrrolidone (PVP) or oPRL (100 micrograms/mouse) in saline-PVP [29].
  • Rats received sc injections of ovine PRL (2400 micrograms/250 microliters) in a polyvinylpyrrolidone depot or vehicle every 12 h for 48 h when experiments were performed [30].
  • Daily injections of bGH or bLH, alone or in combination, or estrogens with PVP failed to restore PRL-R [31].
  • At 3 h, cells continue to spread more on fibronectin and NVP than GBL, and the cells on fibronectin had well-defined stress fibers terminating with sharp spikes of vinculin, typical of focal adhesions [32].
  • OBJECTIVE: To determine the efficacy, tolerance and safety of subcutaneous injections of porcine type I collagen-polyvinylpyrrolidone (PVP) in patients with rheumatoid arthritis (RA) [33].

Analytical, diagnostic and therapeutic context of Povidone

  • Contamination of urine with povidone-iodine. Cause of false-positive test for occult blood in urine [34].
  • In the control group (36 patients) the catheter was removed after urethral catheterisation and emptying of the bladder, and in the trial group (42 patients) 50 ml povidone-iodine 2% was instilled and allowed to drain immediately before removal of the catheter [21].
  • INTERVENTIONS: Patients were randomly assigned to receive skin preparation with an aqueous solution of 10% povidone-iodine or an alcoholic solution of 0.5% chlorhexidine before phlebotomy [35].
  • When these rats were given intravenous injections of low-density lipoprotein-colloidal gold complexes, most of the gold (labeled with 195Au) appeared to be taken up by Kupffer cells, as were complexes of colloidal gold with albumin or polyvinylpyrrolidone [36].
  • Clinical studies with povidone-iodine lavage have used dilute solutions which did not remain in the infected space [37].


  1. Povidone-iodine to prevent ophthalmia neonatorum. Petri, A.R., Pietsch, M. N. Engl. J. Med. (1995) [Pubmed]
  2. Pseudobacteremia caused by povidone-iodine solution contaminated with Pseudomonas cepacia. Craven, D.E., Moody, B., Connolly, M.G., Kollisch, N.R., Stottmeier, K.D., McCabe, W.R. N. Engl. J. Med. (1981) [Pubmed]
  3. A controlled trial of povidone-iodine as prophylaxis against ophthalmia neonatorum. Isenberg, S.J., Apt, L., Wood, M. N. Engl. J. Med. (1995) [Pubmed]
  4. Inactivation of HIV by povidone-iodine. Goldenheim, P.D. JAMA (1987) [Pubmed]
  5. Vaginal absorption of povidone-iodine. Vorherr, H., Vorherr, U.F., Mehta, P., Ulrich, J.A., Messer, R.H. JAMA (1980) [Pubmed]
  6. Chemically modified polysulfone hollow fibers with vinylpyrrolidone having improved blood compatibility. Higuchi, A., Shirano, K., Harashima, M., Yoon, B.O., Hara, M., Hattori, M., Imamura, K. Biomaterials (2002) [Pubmed]
  7. Regulation of IgG memory responses by helper and suppressor T cells activated by the type 2 antigen, polyvinylpyrrolidone. Braley-Mullen, H. J. Exp. Med. (1985) [Pubmed]
  8. Cotton dust-mediated lung epithelial injury. Ayars, G.H., Altman, L.C., O'Neil, C.E., Butcher, B.T., Chi, E.Y. J. Clin. Invest. (1986) [Pubmed]
  9. Separation on Percoll density gradients of cells derived from malignant ascites of mice. Hamburger, A.W., Dunn, F.E., Tencer, K.L. J. Natl. Cancer Inst. (1983) [Pubmed]
  10. Clinical and economic consequences of wound sepsis after appendicectomy and their modification by metronidazole or povidone iodine. Foster, G.E., Bourke, J.B., Bolwell, J., Doran, J., Balfour, T.W., Holliday, A., Hardcastle, J.D., Marshall, D.J. Lancet (1981) [Pubmed]
  11. Prevention of wound infection in abdominal operations by peroperative antibiotics or povidone-iodine. A controlled trial. Galland, R.B., Saunders, J.H., Mosley, J.G., Darrell, J.H. Lancet (1977) [Pubmed]
  12. Iodine-induced thyrotoxicosis in a woman with a multinodular goiter taking levothyroxine. Reith, P.E., Granner, D.K. Arch. Intern. Med. (1985) [Pubmed]
  13. Lavage of a mucinous cystadenoma of the pancreas with povidone iodate. Gaia, E., Salacone, P., Cataldi, A. Gut (2006) [Pubmed]
  14. Depletion and exchange of cholesterol from the membrane of vesicular stomatitis virus by interaction with serum lipoproteins or poly(vinylpyrrolidone) complexed with bovine serum albumin. Pal, R., Barenholz, Y., Wagner, R.R. Biochemistry (1981) [Pubmed]
  15. Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Maki, D.G., Ringer, M., Alvarado, C.J. Lancet (1991) [Pubmed]
  16. Clearance capacity of rat liver Kupffer, Endothelial, and parenchymal cells. Praaning-van Dalen, D.P., Brouwer, A., Knook, D.L. Gastroenterology (1981) [Pubmed]
  17. Quantitative studies of pinocytosis. I. Kinetics of uptake of (125I)polyvinylpyrrolidone by rat yolk sac cultured in vitro. Williams, K.E., Kidston, E.M., Beck, F., Lloyd, J.B. J. Cell Biol. (1975) [Pubmed]
  18. Thymic function in NZB mice. II. Regulatory influence of a circulating thymic factor on antibody production against polyvinylpyrrolidone in NZB mice. Bach, M.A., Niaudet, P. J. Immunol. (1976) [Pubmed]
  19. Expression of biologically active human insulin-like growth factor-I following intramuscular injection of a formulated plasmid in rats. Alila, H., Coleman, M., Nitta, H., French, M., Anwer, K., Liu, Q., Meyer, T., Wang, J., Mumper, R., Oubari, D., Long, S., Nordstrom, J., Rolland, A. Hum. Gene Ther. (1997) [Pubmed]
  20. Effect of povidone-iodine on neonatal thyroid function. Jackson, H.J., Sutherland, R.M. Lancet (1981) [Pubmed]
  21. Bladder irrigation with povidone-iodine in prevention of urinary-tract infections associated with intermittent urethral catheterisation. van den Broek, P.J., Daha, T.J., Mouton, R.P. Lancet (1985) [Pubmed]
  22. Quantitative studies of pinocytosis. II. Kinetics of protein uptake and digestion by rat yolk sac cultured in vitro. Williams, K.E., Kidston, E.M., Beck, F., Lloyd, J.B. J. Cell Biol. (1975) [Pubmed]
  23. Sternotomy infections with Mycoplasma hominis. Steffenson, D.O., Dummer, J.S., Granick, M.S., Pasculle, A.W., Griffith, B.P., Cassell, G.H. Ann. Intern. Med. (1987) [Pubmed]
  24. Complications of povidone-iodine absorption in topically treated burn patients. Pietsch, J., Meakins, J.L. Lancet (1976) [Pubmed]
  25. Movement of a karyophilic protein through the nuclear pores of oocytes. Feldherr, C.M., Kallenbach, E., Schultz, N. J. Cell Biol. (1984) [Pubmed]
  26. Ethanol-induced inhibition of pinocytosis and proteolysis in rat yolk sac in vitro. Steventon, G.B., Williams, K.E. Development (1987) [Pubmed]
  27. Production of idiotypic and anti-idiotypic antibodies by BALB/c mice in response to immunizations with glucagon, vasopressin, or insulin: supporting evidence for the network concept. Reilly, T.M., Root, R.T. J. Immunol. (1986) [Pubmed]
  28. Staphylococcus aureus prophylaxis in hemodialysis patients using central venous catheter: effect of mupirocin ointment. Sesso, R., Barbosa, D., Leme, I.L., Sader, H., Canziani, M.E., Manfredi, S., Draibe, S., Pignatari, A.C. J. Am. Soc. Nephrol. (1998) [Pubmed]
  29. Interactions of human growth hormone and prolactin on pituitary and Leydig cell function in adult transgenic mice expressing the human growth hormone gene. Chandrashekar, V., Bartke, A., Wagner, T.E. Biol. Reprod. (1991) [Pubmed]
  30. Hyperprolactinemia suppresses the luteinizing hormone responses to N-methyl-D-aspartate, epinephrine, and neuropeptide-Y in male rats. Park, S.K., Selmanoff, M. Endocrinology (1993) [Pubmed]
  31. Prolactin induces its own receptors in rat liver. Manni, A., Chambers, M.J., Pearson, O.H. Endocrinology (1978) [Pubmed]
  32. Endothelial cell formation of focal adhesions on hydrophilic plasma polymers. Sanborn, S.L., Murugesan, G., Marchant, R.E., Kottke-Marchant, K. Biomaterials (2002) [Pubmed]
  33. Subcutaneous administration of polymerized-type I collagen for the treatment of patients with rheumatoid arthritis. An open-label pilot trial. Furuzawa-Carballeda, J., Cabral, A.R., Zapata-Zuñiga, M., Alcocer-Varela, J. J. Rheumatol. (2003) [Pubmed]
  34. Contamination of urine with povidone-iodine. Cause of false-positive test for occult blood in urine. Said, R. JAMA (1979) [Pubmed]
  35. Chlorhexidine compared with povidone-iodine as skin preparation before blood culture. A randomized, controlled trial. Mimoz, O., Karim, A., Mercat, A., Cosseron, M., Falissard, B., Parker, F., Richard, C., Samii, K., Nordmann, P. Ann. Intern. Med. (1999) [Pubmed]
  36. Hepatic metabolism of colloidal gold-low-density lipoprotein complexes in the rat: evidence for bulk excretion of lysosomal contents into bile. Renaud, G., Hamilton, R.L., Havel, R.J. Hepatology (1989) [Pubmed]
  37. Intraperitoneal povidone-iodine in experimental peritonitis. Lagarde, M.C., Bolton, J.S., Cohn, I. Ann. Surg. (1978) [Pubmed]
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