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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Bradykinin antagonizes morphine-induced analgesia in rats.

The intraventricular injection of 5 micrograms of bradykinin or Met-Lys-bradykinin in rats antagonized the increase in nociception threshold induced by morphine (5 micrograms i.c.v. or 10 mg/kg i.p.) in the tail flick test. The effect of the two kinins was prevented by atropine (30 mg/kg i.p.). The results suggest that bradykinin counteracts opiate activity in the central nervous system by enhancing acetylcholine release.[1]

References

  1. Bradykinin antagonizes morphine-induced analgesia in rats. Argiolas, A., Melis, M.R., Gessa, G.L. Eur. J. Pharmacol. (1985) [Pubmed]
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