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Chemical Compound Review:

Met-kallidin (2S)-2-[[(2S)-2-[[(2S)-1- [(2S)-2-[[(2S)-2...

Synonyms: AC1MHZDS, 550-19-6, Met-lys-bradykinin, bradykinin, Met-Lys-, Bradykinin, methionyl-lysine-, ...

Figarella, C. et al., Geiger, R. et al., Argiolas, A. et al., Diekmann, O. et al., Amouric, M. et al., et al.

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Disease relevance of Met-lys-bradykinin

Stimulation of bone resorption in cultured mouse calvaria by met-lys-bradykinin [1].

High impact information on Met-lys-bradykinin

45Ca2+ efflux was also demonstrated with Lys-bradykinin and Met-Lys-bradykinin but not by des-Arg10-kallidin (100 nM) or NKA (1 microM) [2].
The intraventricular injection of 5 micrograms of bradykinin or Met-Lys-bradykinin in rats antagonized the increase in nociception threshold induced by morphine (5 micrograms i.c.v. or 10 mg/kg i.p.) in the tail flick test [3].
We found that ascidian plasma, Mg2+, and Met-Lys-bradykinin can induce the hemocytes of H. roretzi to aggregate [4].
4. Under the same conditions, bradykinin and Met-Lys-bradykinin were cleaved by PMNL-collagenase at a rate of 20% in 24 h, producing BK(1-7) and BK(1-8) [5].
The monoclonal antibody (IgG1) bound to bradykinin, Lys-bradykinin, Met-Lys-bradykinin, and kininogens in ELISA [6].

Biological context of Met-lys-bradykinin

Cross-reaction of anti-bradykinin antisera occurred with kallidin and met-lys-bradykinin [7].

Anatomical context of Met-lys-bradykinin

Human trypsins 1 and 2 both converted Met-Lys-bradykinin to bradykinin and released bradykinin from kininogen in human plasma as measured by bioassay with the isolated guinea pig ileum [8].

Gene context of Met-lys-bradykinin

Comparison of the kininogenase activity of human pancreatic trypsins and porcine Kallikrein on Met-Lys-bradykinin and human plasma kininogen [8].
Porcine kallikrein did not act on Met-Lys-bradykinin and released kallidin from human kininogen [8].
Contrary to the two human trypsins, human kallikrein like porcine pancreatic kallikrein is unable to hydrolyse casein and Met-Lys-bradykinin [9].

Analytical, diagnostic and therapeutic context of Met-lys-bradykinin

A high performance liquid chromatography system was developed for the quantitative separation and determination of bradykinin, kallidin and Met-Lys-bradykinin using a reversed-phase column (Nucleosil 5 C8) and an isocratic buffer system [10].

References

Stimulation of bone resorption in cultured mouse calvaria by met-lys-bradykinin. Ljunggren, O., Lerner, U.H. J. Periodont. Res. (1988) [Pubmed]
Characterization of bradykinin B2 receptors on human IMR-90 lung fibroblasts: stimulation of 45Ca2+ efflux by D-Phe substituted bradykinin analogues. Sawutz, D.G., Faunce, D.M., Houck, W.T., Haycock, D. Eur. J. Pharmacol. (1992) [Pubmed]
Bradykinin antagonizes morphine-induced analgesia in rats. Argiolas, A., Melis, M.R., Gessa, G.L. Eur. J. Pharmacol. (1985) [Pubmed]
Hemocyte aggregation in the solitary ascidian Halocynthia roretzi: plasma factors, magnesium ion, and Met-Lys-bradykinin induce the aggregation. Takahashi, H., Azumi, K., Yokosawa, H. Biol. Bull. (1994) [Pubmed]
Degradation of kinins, angiotensins and substance P by polymorphonuclear matrix metalloproteinases MMP 8 and MMP 9. Diekmann, O., Tschesche, H. Braz. J. Med. Biol. Res. (1994) [Pubmed]
Tissue distribution and kininogen gene expression after acute-phase inflammation. Chao, J., Swain, C., Chao, S., Xiong, W., Chao, L. Biochim. Biophys. Acta (1988) [Pubmed]
Production of antibodies against bradykinin. Stocker, M., Hilgenfeldt, U., Gross, F. Experientia (1979) [Pubmed]
Comparison of the kininogenase activity of human pancreatic trypsins and porcine Kallikrein on Met-Lys-bradykinin and human plasma kininogen. Figarella, C., Sampaio, M.U., Greene, L.J. Hoppe-Seyler's Z. Physiol. Chem. (1978) [Pubmed]
Some properties of human pancreatic kallikrein and comparison with human trypsins and porcine kallikrein. Amouric, M., Figarella, C. Hoppe-Seyler's Z. Physiol. Chem. (1980) [Pubmed]
Determination of bradykinin, kallidin and Met-Lys-bradykinin by high performance liquid chromatography. Geiger, R., Hell, R., Fritz, H. Hoppe-Seyler's Z. Physiol. Chem. (1982) [Pubmed]

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