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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Growth of mammalian cells in the absence of the accumulation of spermine.

Mammalian spermine synthase activity was strongly inhibited by S-methyl-5'-methylthioadenosine. This nucleoside was readily taken up by SV-3T3 cells and blocked the synthesis of spermine by these cells. However, there was a corresponding increase in spermidine content and there was no effect on cell growth. These results indicate that S-methyl-5'-methylthioadenosine should be a useful compound to evaluate the role of spermine in mammalian cell physiology and that in at least one cell line the synthesis of spermine is not required for a normal growth rate.[1]

References

  1. Growth of mammalian cells in the absence of the accumulation of spermine. Pegg, A.E., Coward, J.K. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
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