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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Growth of mammalian cells in the absence of the accumulation of spermine.

Mammalian spermine synthase activity was strongly inhibited by S-methyl-5'-methylthioadenosine. This nucleoside was readily taken up by SV-3T3 cells and blocked the synthesis of spermine by these cells. However, there was a corresponding increase in spermidine content and there was no effect on cell growth. These results indicate that S-methyl-5'-methylthioadenosine should be a useful compound to evaluate the role of spermine in mammalian cell physiology and that in at least one cell line the synthesis of spermine is not required for a normal growth rate.[1]


  1. Growth of mammalian cells in the absence of the accumulation of spermine. Pegg, A.E., Coward, J.K. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
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