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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Physiology

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Disease relevance of Cell Physiology


High impact information on Cell Physiology

  • In this review, we define all known MAPK module kinases from yeast to humans, what is known about their regulation, defined MAPK substrates, and the function of MAPK in cell physiology [4].
  • Actin filament assembly is a tightly regulated process that functions in many aspects of cell physiology [5].
  • The non-receptor tyrosine kinase Src is important for many aspects of cell physiology [6].
  • New developments in the area of corticotrope cell physiology are discussed, highlighting evidence for dual ACTH secreting pathways in anterior pituitary cells, which may be controlled separately by AVP and CRF-41 [7].
  • Modulators of G-protein signaling have a central role in controlling cell physiology and represent over half of all marketed prescription drugs [8].

Biological context of Cell Physiology


Anatomical context of Cell Physiology


Associations of Cell Physiology with chemical compounds


Gene context of Cell Physiology

  • The heat shock protein (Hsp) 70/Hsp40 chaperone system plays an essential role in cell physiology, but few of its in vivo functions are known [24].
  • Thus, altering HER2 concentrations, either overall or local, could provide an effective mechanism for regulating EGFR/HER2 heterodimerization and may explain why HER2 overexpression found in some cancers has such a profound effect on cell physiology [25].
  • These data will help define the biochemical role of the FA core complex in normal cell physiology as well as in the development of the FA disease state [26].
  • Thus, Arl3 is a ubiquitously expressed GTP-binding protein in the ARF family with distinctive biochemical properties consistent with its having unique, but unknown, role(s) in cell physiology [27].
  • Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: implications in bone cell physiology [28].

Analytical, diagnostic and therapeutic context of Cell Physiology


  1. Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species. Goyal, P., Weissmann, N., Grimminger, F., Hegel, C., Bader, L., Rose, F., Fink, L., Ghofrani, H.A., Schermuly, R.T., Schmidt, H.H., Seeger, W., Hänze, J. Free Radic. Biol. Med. (2004) [Pubmed]
  2. Functional characterization of Escherichia coli GlpG and additional rhomboid proteins using an aarA mutant of Providencia stuartii. Clemmer, K.M., Sturgill, G.M., Veenstra, A., Rather, P.N. J. Bacteriol. (2006) [Pubmed]
  3. Pancreas cell physiology and pancreatitis cell biology. Summary of a symposium held at the joint meeting of the EPC and the IAP, Heidelberg 2002. Gorelick, F.S. Pancreatology (2003) [Pubmed]
  4. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Widmann, C., Gibson, S., Jarpe, M.B., Johnson, G.L. Physiol. Rev. (1999) [Pubmed]
  5. Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration. Renfranz, P.J., Beckerle, M.C. Curr. Opin. Cell Biol. (2002) [Pubmed]
  6. The hunting of the Src. Martin, G.S. Nat. Rev. Mol. Cell Biol. (2001) [Pubmed]
  7. Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age. Antoni, F.A. Frontiers in neuroendocrinology. (1993) [Pubmed]
  8. G-protein-directed ligand discovery with peptide combinatorial libraries. Ja, W.W., Roberts, R.W. Trends Biochem. Sci. (2005) [Pubmed]
  9. Nup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene. Gigliotti, S., Callaini, G., Andone, S., Riparbelli, M.G., Pernas-Alonso, R., Hoffmann, G., Graziani, F., Malva, C. J. Cell Biol. (1998) [Pubmed]
  10. Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology. Brorson, J.R., Schumacker, P.T., Zhang, H. J. Neurosci. (1999) [Pubmed]
  11. Heteromeric amino acid transporters: biochemistry, genetics, and physiology. Chillarón, J., Roca, R., Valencia, A., Zorzano, A., Palacín, M. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  12. MEN1 tumor-suppressor protein localizes to telomeres during meiosis. Suphapeetiporn, K., Greally, J.M., Walpita, D., Ashley, T., Bale, A.E. Genes Chromosomes Cancer (2002) [Pubmed]
  13. Transcriptome and Phenotypic Responses of Vibrio cholerae to Increased Cyclic di-GMP Level. Beyhan, S., Tischler, A.D., Camilli, A., Yildiz, F.H. J. Bacteriol. (2006) [Pubmed]
  14. Gq alpha protein function in vivo: genetic dissection of its role in photoreceptor cell physiology. Scott, K., Becker, A., Sun, Y., Hardy, R., Zuker, C. Neuron (1995) [Pubmed]
  15. Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton. Goodson, H.V., Anderson, B.L., Warrick, H.M., Pon, L.A., Spudich, J.A. J. Cell Biol. (1996) [Pubmed]
  16. Pyridine nucleotides and calcium signalling in arterial smooth muscle: from cell physiology to pharmacology. Evans, A.M., Wyatt, C.N., Kinnear, N.P., Clark, J.H., Blanco, E.A. Pharmacol. Ther. (2005) [Pubmed]
  17. Characterization of carbonyl reducing activity in continuous cell lines of human and rodent origin. Gebel, T., Maser, E. Biochem. Pharmacol. (1992) [Pubmed]
  18. Extracellular matrix components of the mouse thymic microenvironment. III. Thymic epithelial cells express the VLA6 complex that is involved in laminin-mediated interactions with thymocytes. Lannes-Vieira, J., Chammas, R., Villa-Verde, D.M., Vannier-dos-Santos, M.A., Mello-Coelho, V., de Souza, S.J., Brentani, R.R., Savino, W. Int. Immunol. (1993) [Pubmed]
  19. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Peterson, J.D., Herzenberg, L.A., Vasquez, K., Waltenbaugh, C. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  20. Plasminogen activation by normal B lymphocytes, a function associated with the cell membrane. Maillard, J.L., Favreau, C. J. Immunol. (1981) [Pubmed]
  21. Differential stimulation of fos and jun family members by calcitriol in osteoblastic cells. Candeliere, G.A., Prud'homme, J., St-Arnaud, R. Mol. Endocrinol. (1991) [Pubmed]
  22. Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate. Xu, Y., Lee, S.A., Kutateladze, T.G., Sbrissa, D., Shisheva, A., Prestwich, G.D. J. Am. Chem. Soc. (2006) [Pubmed]
  23. Melatonin as a cytoskeletal modulator: implications for cell physiology and disease. Benítez-King, G. J. Pineal Res. (2006) [Pubmed]
  24. Mutations in the yeast Hsp40 chaperone protein Ydj1 cause defects in Axl1 biogenesis and pro-a-factor processing. Meacham, G.C., Browne, B.L., Zhang, W., Kellermayer, R., Bedwell, D.M., Cyr, D.M. J. Biol. Chem. (1999) [Pubmed]
  25. Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels. Hendriks, B.S., Opresko, L.K., Wiley, H.S., Lauffenburger, D. J. Biol. Chem. (2003) [Pubmed]
  26. The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments. Thomashevski, A., High, A.A., Drozd, M., Shabanowitz, J., Hunt, D.F., Grant, P.A., Kupfer, G.M. J. Biol. Chem. (2004) [Pubmed]
  27. ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues. Cavenagh, M.M., Breiner, M., Schurmann, A., Rosenwald, A.G., Terui, T., Zhang, C., Randazzo, P.A., Adams, M., Joost, H.G., Kahn, R.A. J. Biol. Chem. (1994) [Pubmed]
  28. Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: implications in bone cell physiology. Durham, S.K., Kiefer, M.C., Riggs, B.L., Conover, C.A. J. Bone Miner. Res. (1994) [Pubmed]
  29. Modeling, optimization and experimental assessment of continuous L-(-)-carnitine production by Escherichia coli cultures. Alvarez-Vasquez, F., Cánovas, M., Iborra, J.L., Torres, N.V. Biotechnol. Bioeng. (2002) [Pubmed]
  30. Comparison of combination of dipyridamole and dobutamine during echocardiography with thallium scintigraphy with thallium scintigraphy to improve viability detection. Sicari, R., Varga, A., Picano, E., Borges, A.C., Gimelli, A., Marzullo, P. Am. J. Cardiol. (1999) [Pubmed]
  31. Induction of apoptosis in rat thecal/interstitial cells by transforming growth factor alpha plus transforming growth factor beta in vitro. Foghi, A., Teerds, K.J., van der Donk, H., Dorrington, J. J. Endocrinol. (1997) [Pubmed]
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