Disease relevance of Cell Physiology

• Hypoxia sensing and related signaling events, including activation of hypoxia-inducible factor 1 (HIF-1), represent key features in cell physiology and lung function [1].
• In an effort to further investigate the role of a rhomboid protein in cell physiology, a glpG mutant of E. coli was constructed [2].
• Pancreas cell physiology and pancreatitis cell biology. Summary of a symposium held at the joint meeting of the EPC and the IAP, Heidelberg 2002 [3].

High impact information on Cell Physiology

• In this review, we define all known MAPK module kinases from yeast to humans, what is known about their regulation, defined MAPK substrates, and the function of MAPK in cell physiology [4].
• Actin filament assembly is a tightly regulated process that functions in many aspects of cell physiology [5].
• The non-receptor tyrosine kinase Src is important for many aspects of cell physiology [6].
• New developments in the area of corticotrope cell physiology are discussed, highlighting evidence for dual ACTH secreting pathways in anterior pituitary cells, which may be controlled separately by AVP and CRF-41 [7].
• Modulators of G-protein signaling have a central role in controlling cell physiology and represent over half of all marketed prescription drugs [8].

Biological context of Cell Physiology

• Finally, the multiplicity of phenotypes observed in Nup154 mutant alleles suggests that this gene plays a crucial role in cell physiology [9].
• Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology [10].
• This review covers the biochemistry, human genetics, and cell physiology of HATs, including the multifunctional character of CD98 [11].
• Menin has been shown negatively to regulate transcriptional activation mediated by JunD, although the significance of this interaction in normal cell physiology and how the absence of menin leads to tumorigenesis are unknown [12].
• In many microorganisms, the second messenger, 3',5'-cyclic diguanylic acid (c-di-GMP), is believed to be important for integrating environmental stimuli that affect cell physiology [13].

Anatomical context of Cell Physiology

• Gq alpha protein function in vivo: genetic dissection of its role in photoreceptor cell physiology [14].
• The organization of the actin cytoskeleton plays a critical role in cell physiology in motile and nonmotile organisms [15].
• Pyridine nucleotides and calcium signalling in arterial smooth muscle: from cell physiology to pharmacology [16].
• According to its maintenance in permanent cell lines carbonyl reductase seems to be an essential and constitutive enzyme, which probably fills an important role in normal cell physiology [17].
• Our results suggest that VLA6 is involved in LN-mediated TEC-thymocyte interactions that can be relevant for thymic microenvironmental cell physiology and intrathymic T cell differentiation events [18].

Associations of Cell Physiology with chemical compounds

• Here we introduce glutathione, a tripeptide that regulates intracellular redox and other aspects of cell physiology, as a key regulatory element in this process [19].
• The fast renewal of the enzyme in the membrane was also demonstrated by different techniques, using modifiers of cell physiology, like cycloheximide and dexamethasone, or following the reexpression of the enzyme by the cell kinetically [20].
• The differential stimulation of the expression of certain members of the fos and jun families by calcitriol support a role for these oncoproteins in bone cell physiology [21].
• To provide chemical tools to study the changes in cell physiology mediated by these lipids, three new metabolically stabilized (ms) analogues of phosphatidylinositol-3-phosphate (PtdIns(3)P) were synthesized [22].
• Melatonin as a cytoskeletal modulator: implications for cell physiology and disease [23].

Gene context of Cell Physiology

• The heat shock protein (Hsp) 70/Hsp40 chaperone system plays an essential role in cell physiology, but few of its in vivo functions are known [24].
• Thus, altering HER2 concentrations, either overall or local, could provide an effective mechanism for regulating EGFR/HER2 heterodimerization and may explain why HER2 overexpression found in some cancers has such a profound effect on cell physiology [25].
• These data will help define the biochemical role of the FA core complex in normal cell physiology as well as in the development of the FA disease state [26].
• Thus, Arl3 is a ubiquitously expressed GTP-binding protein in the ARF family with distinctive biochemical properties consistent with its having unique, but unknown, role(s) in cell physiology [27].
• Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: implications in bone cell physiology [28].

Analytical, diagnostic and therapeutic context of Cell Physiology

• This optimization approach provides different parameter value profiles, all of which are compatible with the cell physiology and the bioreactor operating conditions, that yield increased rates of L-(-)-carnitine production [29].
• Myocardial viability can be detected by techniques exploring various aspects of cell physiology: thallium-201 scintigraphy and dobutamine and dipyridamole echocardiography focus on cell membrane integrity, beta-1 and adrenoceptor, and A2-adenosine receptor-mediated inotropic response, respectively [30].
• Since transforming growth factor (TGF) alpha and TGF beta 1 have been implicated in the regulation of thecal cell physiology we have localized these growth factors by immunohistochemistry in sections of ovaries from 25-day-old rats, an age at which the ovary exhibits a wave of atresia of preantral follicles [31].

References