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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Paradoxical excitement following the intravenous administration of azaperone in the horse.

The rapid intravenous administration of the butyrophenone tranquilliser, azaperone, at a dose rate of 0.29-0.57 mg/kg body weight resulted in the immediate onset of excitement and ataxia of varying degree in over half the animals. The severity of the reaction appeared to be related to the size of the animal. Other side effects such as salivation, sweating, muscle tremor and vocalisation were also observed. The possible causes of this paradoxical reaction to the tranquilliser are discussed.[1]


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