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Renal papillary necrosis and pyelonephritis accompanying fenoprofen therapy.

Renal papillary necrosis occurred after fenoprofen calcium administration in a patient with systemic lupus erythematosus and urinary tract infection. Possible mechanisms of renal damage may be hypersensitivity, decreased blood flow, and decreased production of a prostaglandin E-like substance.[1]


  1. Renal papillary necrosis and pyelonephritis accompanying fenoprofen therapy. Husserl, F.E., Lange, R.K., Kantrow, C.M. JAMA (1979) [Pubmed]
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