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Chemical Compound Review

Nalgesic     2-(3-phenoxyphenyl)propanoic acid

Synonyms: Feprona, Nalfon, fenoprofen, Fenoprofene, Fenoprofeno, ...
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Disease relevance of fenoprofen


High impact information on fenoprofen


Chemical compound and disease context of fenoprofen


Biological context of fenoprofen

  • It is suggested that the various clinical and pathologic findings in fenoprofen nephropathy are all manifestations of a disordered cell-mediated immunity [7].
  • Studies were conducted on postpartum and postoperative patients to estimate the dose-response line of fenoprofen and to contrast it with codeine and placebo [12].
  • Linear pharmacokinetics of orally administered fenoprofen calcium [13].
  • These data show linearity of kinetics for fenoprofen in plasma throughout the 60--300-mg dosage range after a single dose [13].
  • The bioavailability parameters Cmax, tmax, and AUC0--12 hr for the drug in plasma were consistent with a linear pharmacokinetic model, as were the amounts of fenoprofen and hydroxyfenoprofen excreted in the urine [13].

Anatomical context of fenoprofen


Associations of fenoprofen with other chemical compounds


Gene context of fenoprofen


Analytical, diagnostic and therapeutic context of fenoprofen


  1. Acute thrombocytopenia associated with fenoprofen. Simpson, R.E., Goldstein, D.J., Hjelte, G.S., Evans, E.R. N. Engl. J. Med. (1978) [Pubmed]
  2. Fenoprofen and agranulocytosis. Simon, S.D., Kosmin, M. N. Engl. J. Med. (1978) [Pubmed]
  3. Renal papillary necrosis and pyelonephritis accompanying fenoprofen therapy. Husserl, F.E., Lange, R.K., Kantrow, C.M. JAMA (1979) [Pubmed]
  4. Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. Loebl, D.H., Craig, R.M., Culic, D.D., Ridolfo, A.S., Falk, J., Schmid, F.R. JAMA (1977) [Pubmed]
  5. Nonsteroidal anti-inflammatory agents in rheumatoid arthritis and ankylosing spondylitis. Wasner, C., Britton, M.C., Kraines, R.G., Kaye, R.L., Bobrove, A.M., Fries, J.F. JAMA (1981) [Pubmed]
  6. Controlled trial of homoeopathic treatment of osteoarthritis. Shipley, M., Berry, H., Broster, G., Jenkins, M., Clover, A., Williams, I. Lancet (1983) [Pubmed]
  7. Fenoprofen nephropathy: lipoid nephrosis and interstitial nephritis. A possible T-lymphocyte disorder. Finkelstein, A., Fraley, D.S., Stachura, I., Feldman, H.A., Gandy, D.R., Bourke, E. Am. J. Med. (1982) [Pubmed]
  8. Thioesterification of 2-arylpropionic acids by recombinant acyl-coenzyme A synthetases (ACS1 and ACS2). Sevoz, C., Benoit, E., Buronfosse, T. Drug Metab. Dispos. (2000) [Pubmed]
  9. A double-blind comparison of parenteral morphine, placebo, and oral fenoprofen in management of postoperative pain. Davie, I.T., Slawson, K.B., Burt, R.A. Anesth. Analg. (1982) [Pubmed]
  10. Ocular anti-inflammatory effect of fenoprofen. Dose-response study. Harris, L.S., Kahanowicz, Y. Arch. Ophthalmol. (1975) [Pubmed]
  11. A comparison between fenoprofen calcium and naproxen sodium in the treatment of soft tissue sports injuries. Mann, P.G. Pharmatherapeutica. (1983) [Pubmed]
  12. Fenoprofen and codeine analgesia. Laska, E.M., Sunshine, A. Clin. Pharmacol. Ther. (1981) [Pubmed]
  13. Linear pharmacokinetics of orally administered fenoprofen calcium. Nash, J.F., Bechtol, L.D., Bunde, C.A., Bopp, R.J., Farid, K.Z., Spradlin, C.T. Journal of pharmaceutical sciences. (1979) [Pubmed]
  14. T and B lymphocyte subsets in fenoprofen nephropathy. Stachura, I., Jayakumar, S., Bourke, E. Am. J. Med. (1983) [Pubmed]
  15. Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations. Szczeklik, A., Gryglewski, R.J., Czerniawska-Mysik, G., Zmuda, A. J. Allergy Clin. Immunol. (1976) [Pubmed]
  16. The stereospecific incorporation of fenoprofen into rat hepatocyte and adipocyte triacylglycerols. Sallustio, B.C., Meffin, P.J., Knights, K.M. Biochem. Pharmacol. (1988) [Pubmed]
  17. Presystemic and systemic chiral inversion of R-(-)-fenoprofen in the rat. Berry, B.W., Jamali, F. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  18. Benoxaprofen stimulates proteoglycan synthesis in normal canine knee cartilage in vitro. Palmoski, M.J., Brandt, K.D. Arthritis Rheum. (1983) [Pubmed]
  19. Enteric coating of fenoprofen calcium reduces gastrointestinal microbleeding. Ryan, J.R., Riley, W.A., Vargas, R., Offen, W.W., Gruber, C.M. Clin. Pharmacol. Ther. (1987) [Pubmed]
  20. Studies on the effect of fenoprofen on the activation and oxidation of long chain and very long chain fatty acids in hepatocytes and subcellular fractions from rat liver. Lageweg, W., Wanders, R.J. Biochem. Pharmacol. (1993) [Pubmed]
  21. Peroxisome-proliferating effects of fenoprofen in mice. De Craemer, D., Van den Branden, C., Pauwels, M., Vamecq, J. Lipids (1998) [Pubmed]
  22. Fenoprofen: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases. Brogden, R.N., Pinder, R.M., Speight, T.M., Avery, G.S. Drugs (1977) [Pubmed]
  23. Nonsteroidal anti-inflammatory drugs and coma: a case report of fenoprofen overdose. Kolodzik, J.M., Eilers, M.A., Angelos, M.G. Annals of emergency medicine. (1990) [Pubmed]
  24. Comparison of gastrointestinal effects of aspirin and fenoprofen. A double blind crossover study. Chernish, S.M., Rosenak, B.D., Brunelie, R.L., Crabtree, R. Arthritis Rheum. (1979) [Pubmed]
  25. (-)-R-fenoprofen: formation of fenoprofenyl-coenzyme A by rat liver microsomes. Benoit, E., Delatour, P., Olivier, L., Caldwell, J. Biochem. Pharmacol. (1995) [Pubmed]
  26. Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing. Shirey, R.S., Morton, S.J., Lawton, K.B., Lowell, C., Kickler, T.S., Ness, P.M. Am. J. Clin. Pathol. (1988) [Pubmed]
  27. Stereoselective inversion of (R)-fenoprofen to (S)-fenoprofen in humans. Rubin, A., Knadler, M.P., Ho, P.P., Bechtol, L.D., Wolen, R.L. Journal of pharmaceutical sciences. (1985) [Pubmed]
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