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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A gastroscopic and pharmacological study of the disintegration time and absorption of pivampicillin capsules and tablets.

1 An in vitro investigation showed that pivampicillin tablets disintegrated more rapidly than pivampicillin capsules. This result was demonstrated and confirmed by gastroscopy in a cross-over study in healthy volunteers. 2 There were no differences in serum levels of ampicillin obtained with the two preparations, but compared with non-gastroscoped volunteers, there was delay of 0.5--1.5 h in the appearance of peak serum ampicillin concentrations after gastroscopy. 3 Half of the volunteers receiving pivampicillin capsules developed hyperaemia, interstitial bleeding or erosions of the gastric mucous membrane. No such reactions were seen after pivampicillin tablets. 4 In one volunteer, a pivampicillin capsule was trapped in a not previously noticed hiatus hernia and local changes and pain occurred.[1]

References

  1. A gastroscopic and pharmacological study of the disintegration time and absorption of pivampicillin capsules and tablets. Hey, H., Matzen, P., Andersen, J.T., Didriksen, E., Nielsen, B. British journal of clinical pharmacology. (1979) [Pubmed]
 
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