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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hernia


High impact information on Hernia

  • CONCLUSIONS: Among patients with midline abdominal incisional hernias, mesh repair is superior to suture repair with regard to the recurrence of hernia, regardless of the size of the hernia [6].
  • Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations [7].
  • Phleboliths, and especially diverticular disease and hiatus hernia, are rarer in developing countries than in economically more developed communities, but all three conditions were as common in Black as in White Americans [8].
  • Acquired defects of protein C developed after surgery in the patients operated on for malignancies, after major abdominal operations for benign conditions, and also after relatively minor procedures such as appendicectomy and hernia repair [9].
  • In a second group, incisional hernias were repaired with either bFGF or control-rod therapy [10].

Chemical compound and disease context of Hernia

  • The first scientific description of this particular hernia was given by August Gottlob Richter in 1778, who presented it as "the small rupture." In 1887, Sir Frederick Treves gave an excellent overview on the topic and proposed the title "Richter's hernia." To his work-a cornerstone to modern understanding-hardly any new aspects can be added today [11].
  • The evolution of this approach during the last 10 years has made it the procedure of choice for the management of all recurrent groin hernias at the University of Illinois College of Medicine [12].
  • Hernias occurred less frequently in those receiving 150 mg/d of raloxifene or CEE (P =.03 vs placebo) [13].
  • In children undergoing myringotomy, hernia repair, tonsillectomy, or other surgery associated with mild to moderate pain, ketorolac provides comparable analgesia to morphine, pethidine or paracetamol (acetaminophen) [14].
  • Luminal diameters of the ductal structures were compared with published normal age-related established vas deferens diameters and with those measured during hernia repair in 10 of our youngest patients [15].

Biological context of Hernia


Anatomical context of Hernia


Gene context of Hernia

  • In addition, our transgenic data indicate that the Hoxb1 gene is expressed in other tissues such as the hernia gut, genital eminence, and lung [26].
  • Changes in CRP levels were significantly higher (P < 0.006) in open hernia patients [27].
  • We conclude that in contrast to the unchanged expression of fibronectin and MMP-1 and MMP-13, the decreased ratios of collagen tpye I/III with the basically increased amount of collagen type III could be of significant importance for the pathophysiology of hernias [28].
  • We obtained samples of FT from patients with direct and indirect hernia and used an immunohistochemical method to determine tissue inhibitor of metalloproteinase-2 (TIMP-2) expression [29].
  • Aim of this study was to evaluate the production of some cytokines [interleukin (IL)-6, IL-10, IL-1alpha, IL-1ra, interferon (IFN)-gamma] in the drainage wound fluid from patients undergoing incisional hernia repair [30].

Analytical, diagnostic and therapeutic context of Hernia


  1. Effects of sleeping with the bed-head raised and of ranitidine in patients with severe peptic oesophagitis. Harvey, R.F., Gordon, P.C., Hadley, N., Long, D.E., Gill, T.R., Macpherson, R.I., Beats, B.C., Tottle, A.J. Lancet (1987) [Pubmed]
  2. IgA class reticulin antibodies in relatives of patients with coeliac disease. Mallas, E.G., Williamson, N., Cooper, B.T., Cooke, W.T. Gut (1977) [Pubmed]
  3. Endoscopic sclerotherapy in the management of gastric variceal haemorrhage. Gimson, A.E., Westaby, D., Williams, R. J. Hepatol. (1991) [Pubmed]
  4. A comparison between bupivacaine instillation versus ilioinguinal/iliohypogastric nerve block for postoperative analgesia following inguinal herniorrhaphy in children. Casey, W.F., Rice, L.J., Hannallah, R.S., Broadman, L., Norden, J.M., Guzzetta, P. Anesthesiology (1990) [Pubmed]
  5. Squamous cell papilloma of the esophagus: a clinicopathologic and follow-up study of 25 cases. Carr, N.J., Monihan, J.M., Sobin, L.H. Am. J. Gastroenterol. (1994) [Pubmed]
  6. A comparison of suture repair with mesh repair for incisional hernia. Luijendijk, R.W., Hop, W.C., van den Tol, M.P., de Lange, D.C., Braaksma, M.M., IJzermans, J.N., Boelhouwer, R.U., de Vries, B.C., Salu, M.K., Wereldsma, J.C., Bruijninckx, C.M., Jeekel, J. N. Engl. J. Med. (2000) [Pubmed]
  7. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations. van Herwaarden, M.A., Samsom, M., Smout, A.J. Gastroenterology (2000) [Pubmed]
  8. Prevalence of diverticular disease, hiatus hernia, and pelvic phleboliths in black and white Americans. Burkitt, D.P., Clements, J.L., Eaton, S.B. Lancet (1985) [Pubmed]
  9. Deficiencies of protein C, an inhibitor of blood coagulation. Mannucci, P.M., Vigano, S. Lancet (1982) [Pubmed]
  10. The prevention of incisional hernia formation using a delayed-release polymer of basic fibroblast growth factor. Dubay, D.A., Wang, X., Kuhn, M.A., Robson, M.C., Franz, M.G. Ann. Surg. (2004) [Pubmed]
  11. Richter's hernia and Sir Frederick Treves: an original clinical experience, review, and historical overview. Steinke, W., Zellweger, R. Ann. Surg. (2000) [Pubmed]
  12. The preperitoneal approach and prosthetic buttress repair for recurrent hernia. The evolution of a technique. Nyhus, L.M., Pollak, R., Bombeck, C.T., Donahue, P.E. Ann. Surg. (1988) [Pubmed]
  13. A comparison of the effects of raloxifene and conjugated equine estrogen on bone and lipids in healthy postmenopausal women. Reid, I.R., Eastell, R., Fogelman, I., Adachi, J.D., Rosen, A., Netelenbos, C., Watts, N.B., Seeman, E., Ciaccia, A.V., Draper, M.W. Arch. Intern. Med. (2004) [Pubmed]
  14. Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. Gillis, J.C., Brogden, R.N. Drugs (1997) [Pubmed]
  15. Significance of accessory ductal structures in hernia sacs. Gill, B., Favale, D., Kogan, S.J., Bennett, B., Reda, E., Levitt, S.B. J. Urol. (1992) [Pubmed]
  16. Embryonal remnants in inguinal hernia sacs. Popek, E.J. Hum. Pathol. (1990) [Pubmed]
  17. Effect of surgical repair on respiratory mechanics in congenital diaphragmatic hernia. Sakai, H., Tamura, M., Hosokawa, Y., Bryan, A.C., Barker, G.A., Bohn, D.J. J. Pediatr. (1987) [Pubmed]
  18. Study of biochemical substrate and role of metalloproteinases in fascia transversalis from hernial processes. Bellón, J.M., Buján, J., Honduvilla, N.G., Jurado, F., Gimeno, M.J., Turnay, J., Olmo, N., Lizarbe, M.A. Eur. J. Clin. Invest. (1997) [Pubmed]
  19. Chronic cough and gastroesophageal reflux. Fitzgerald, J.M., Allen, C.J., Craven, M.A., Newhouse, M.T. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1989) [Pubmed]
  20. A comparison of the oxidative stress response and antioxidant capacity of open and laparoscopic hernia repairs. Polat, C., Kahraman, A., Yilmaz, S., Koken, T., Serteser, M., Akbulut, G., Arikan, Y., Dilek, O.N., Gokce, O. Journal of laparoendoscopic & advanced surgical techniques. Part A. (2003) [Pubmed]
  21. Fibroblasts from the transversalis fascia of young patients with direct inguinal hernias show constitutive MMP-2 overexpression. Bellón, J.M., Bajo, A., Ga-Honduvilla, N., Gimeno, M.J., Pascual, G., Guerrero, A., Buján, J. Ann. Surg. (2001) [Pubmed]
  22. Abdominal wall hernia in autosomal dominant polycystic kidney disease. Morris-Stiff, G., Coles, G., Moore, R., Jurewicz, A., Lord, R. The British journal of surgery. (1997) [Pubmed]
  23. The cost-effectiveness of routine histologic examination. Raab, S.S. Am. J. Clin. Pathol. (1998) [Pubmed]
  24. Glandular inclusions in inguinal hernia sacs: morphologic and immunohistochemical distinction from epididymis and vas deferens. Cerilli, L.A., Sotelo-Avila, C., Mills, S.E. Am. J. Surg. Pathol. (2003) [Pubmed]
  25. Ventral hernia with a skin-covered Silastic sheet for newborn infants with a diaphragmatic hernia. Priebe, C.J., Wichern, W.A. Surgery (1977) [Pubmed]
  26. Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice. Huang, D., Chen, S.W., Gudas, L.J. Dev. Dyn. (2002) [Pubmed]
  27. Metabolic and inflammatory responses after laparoscopic and open inguinal hernia repair. Akhtar, K., Kamalky-asl, I.D., Lamb, W.R., Laing, I., Walton, L., Pearson, R.C., Parrott, N.R. Annals of the Royal College of Surgeons of England. (1998) [Pubmed]
  28. Expression of the extracellular matrix proteins collagen I, collagen III and fibronectin and matrix metalloproteinase-1 and -13 in the skin of patients with inguinal hernia. Klinge, U., Zheng, H., Si, Z., Schumpelick, V., Bhardwaj, R.S., Muys, L., Klosterhalfen, B. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (1999) [Pubmed]
  29. Role of TIMP-2 in fascia transversalis on development of inguinal hernias. Abci, I., Bilgi, S., Altan, A. Journal of investigative surgery : the official journal of the Academy of Surgical Research. (2005) [Pubmed]
  30. Production of cytokines at the operation site. Di Vita, G., Patti, R., Vetri, G., Macchiarella, B., D'Agostino, P., Caruso, G., Ferlazzo, V., Arcoleo, F., Sammartano, S., Angileri, M., Cillari, E. Il Giornale di chirurgia. (2005) [Pubmed]
  31. Day care after operations for hernia or varicose veins: a controlled trial. Ruckley, C.V., Cuthbertson, C., Fenwick, N., Prescott, R.J., Garraway, W.M. The British journal of surgery. (1978) [Pubmed]
  32. Faster recovery after anesthesia in infants after intravenous induction with methohexital instead of thiopental. Beskow, A., Werner, O., Westrin, P. Anesthesiology (1995) [Pubmed]
  33. Surgical decision making. Ruckley, C.V., Ferguson, J.B., Cuthbertson, C. The British journal of surgery. (1981) [Pubmed]
  34. Richter hernia in a sacral foramen: new site for richter hernia. Botsford, T.W. Archives of surgery (Chicago, Ill. : 1960) (1977) [Pubmed]
  35. Direct and indirect blood pressure in normotensive and hypertensive subjects. Fagher, B., Magnússon, J., Thulin, T. J. Intern. Med. (1994) [Pubmed]
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