Disease relevance of Hernia

• Smoking more than five cigarettes per day or drinking more than 30 g alcohol per day significantly reduced the effectiveness of ranitidine therapy, but age, sex, body weight, or the presence of a hiatus hernia had no detectable effect [1].
• IgA class reticulin antibodies were not found in patients with Crohn's disease, ulcerative colitis, and hiatus hernia despite a significant incidence of IgG class reticulin antibodies [2].
• The site of gastric variceal haemorrhage was the lesser curve (Group 1) in 13, within a hiatus hernia (Group 2) in six, and fundal with or without associated oesophageal varices (Type 3) in 22 cases [3].
• This study compared the postoperative pain relief provided by simple instillation of bupivacaine into a hernia wound with that provided by ilioinguinal/iliohypogastric (IG/IH) nerve block [4].
• Many cases showed endoscopic evidence of hiatus hernia, gastroesophageal reflux, or esophagitis [5].

High impact information on Hernia

• CONCLUSIONS: Among patients with midline abdominal incisional hernias, mesh repair is superior to suture repair with regard to the recurrence of hernia, regardless of the size of the hernia [6].
• Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations [7].
• Phleboliths, and especially diverticular disease and hiatus hernia, are rarer in developing countries than in economically more developed communities, but all three conditions were as common in Black as in White Americans [8].
• Acquired defects of protein C developed after surgery in the patients operated on for malignancies, after major abdominal operations for benign conditions, and also after relatively minor procedures such as appendicectomy and hernia repair [9].
• In a second group, incisional hernias were repaired with either bFGF or control-rod therapy [10].

Chemical compound and disease context of Hernia

• The first scientific description of this particular hernia was given by August Gottlob Richter in 1778, who presented it as "the small rupture." In 1887, Sir Frederick Treves gave an excellent overview on the topic and proposed the title "Richter's hernia." To his work-a cornerstone to modern understanding-hardly any new aspects can be added today [11].
• The evolution of this approach during the last 10 years has made it the procedure of choice for the management of all recurrent groin hernias at the University of Illinois College of Medicine [12].
• Hernias occurred less frequently in those receiving 150 mg/d of raloxifene or CEE (P =.03 vs placebo) [13].
• In children undergoing myringotomy, hernia repair, tonsillectomy, or other surgery associated with mild to moderate pain, ketorolac provides comparable analgesia to morphine, pethidine or paracetamol (acetaminophen) [14].
• Luminal diameters of the ductal structures were compared with published normal age-related established vas deferens diameters and with those measured during hernia repair in 10 of our youngest patients [15].

Biological context of Hernia

• Embryonal remnants were found in 1.5% of 599 hernia sacs from 427 consecutively operated males aged 37 weeks gestation to 19 years [16].
• These results suggest that respiratory mechanics in CHD, far from improving, frequently deteriorate as a result of repair of the hernia [17].
• No differences in proline hydroxylation were observed between each type of hernia [18].
• Fifteen of the patients complained of symptoms suggestive of GER: radiologic investigation of the upper gastrointestinal tract revealed hiatus hernia and GER in four, hiatus hernia alone in three, GER alone in two, decreased esophageal peristalsis in one and normal findings in four [19].
• RESULTS: Both types of hernia repair caused a significant increase in the oxidative stress response and a decrease in antioxidant activity [20].

Anatomical context of Hernia

• RESULTS: Significant active MMP-2 expression was shown by TF fibroblasts from young patients with direct hernias [21].
• Abdominal wall hernia in autosomal dominant polycystic kidney disease [22].
• Although the histologic examination of routine tissues, such as hernia sacs and intervertebral disks, has shown a low incidence of detecting clinically significant unsuspected disease, the cost-effectiveness of histologic examination has not been determined [23].
• We hypothesized that an antibody to CD10 would react with vas deferens and epididymis and fail to react with hernia sac inclusions, most of which we thought were Mullerian duct-derived structures [24].
• A large hernia can be produced best by suturing a sheet of Dacron reinforced Silastic to the fascia of a midline abdominal incision and covering it with skin flaps [25].

Gene context of Hernia

• In addition, our transgenic data indicate that the Hoxb1 gene is expressed in other tissues such as the hernia gut, genital eminence, and lung [26].
• Changes in CRP levels were significantly higher (P < 0.006) in open hernia patients [27].
• We conclude that in contrast to the unchanged expression of fibronectin and MMP-1 and MMP-13, the decreased ratios of collagen tpye I/III with the basically increased amount of collagen type III could be of significant importance for the pathophysiology of hernias [28].
• We obtained samples of FT from patients with direct and indirect hernia and used an immunohistochemical method to determine tissue inhibitor of metalloproteinase-2 (TIMP-2) expression [29].
• Aim of this study was to evaluate the production of some cytokines [interleukin (IL)-6, IL-10, IL-1alpha, IL-1ra, interferon (IFN)-gamma] in the drainage wound fluid from patients undergoing incisional hernia repair [30].

Analytical, diagnostic and therapeutic context of Hernia

• Day care after operations for hernia or varicose veins: a controlled trial [31].
• BACKGROUND: To determine possible delays in recovery after intravenous anesthesia induction with thiopental, the drug was compared with methohexital in infants 1-12 months of age who were scheduled for hernia repair or circumcision [32].
• Forecasts of length of stay for hernias and varicose veins were accurate but were usually underestimated for major surgery [33].
• Laparotomy showed that a Richter hernia had occurred in the third right sacral foramen [34].
• Hypertensive subjects treated with either placebo (n = 10) or metoprolol (n = 8) and age-matched normotensive subjects (n = 15), selected from a defined patient population waiting for cholecystectomy or hernia repair [35].

References