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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Immunostimulant therapy with levamisole for rheumatoid arthritis.

In a controlled study involving thirty-four patients levamisole was shown to be as effective as D-penicillamine and more effective than placebo in the treatment of rheumatoid arthritis. Its action was slow and was accompanied by a reduction in erythrocyte sedimentation-rate, rheumatoid factor, and technetium index. These properties indicate that it has a specific action like that of D-penicillamine. Stimulation of cell-mediated immunity was evident in patients treated with levamisole, and there was a correlation between such changes and pain relief. Animal models confirmed the absence of anti-inflammatory effect and provided some evidence of enhancement of cell-mediated immunity and macrophage stimulation.[1]

References

  1. Immunostimulant therapy with levamisole for rheumatoid arthritis. Huskisson, E.C., Scott, J., Balme, H.W., Dieppe, P.A., Trapnell, J., Willoughby, D.A. Lancet (1976) [Pubmed]
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