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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cholecystokinin inhibits tail pinch-induced eating in rats.

Peripheral administration of the COOH-terminal octapeptide of cholecystokinin in doses from 1 to 100 micrograms per kilogram of body weight (0.25 to 25.0 micrograms per rat) significantly antagonized tail pinch-induced eating in rats, an animal model for stress-induced human hyperphagia. Centrally administered cholecystokinin was effective only in high doses (3 micrograms into the cerebral ventricle). The finding that the minimal effective dose of cholecystokinin in suppressing stress-induced appetitive behavior is smaller after peripheral than central administration suggests that the peptide is acting on peripheral, as opposed to central nervous system, substrates.[1]


  1. Cholecystokinin inhibits tail pinch-induced eating in rats. Nemeroff, C.B., Osbahr, A.J., Bissette, G., Jahnke, G., Lipton, M.A., Prange, A.J. Science (1978) [Pubmed]
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