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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Galactorrhea, amenorrhea, hyperprolactinemia, and an empty sella.

Increased serum prolactin ( hPRL) and increased volume of the sella turcica as detected by roentgenography are compatible with a pituitary adenoma. The empty sella syndrome can increase sella volume, but is usually associated with minimal, if any, endocrine dysfunction. The present case details a young woman with amenorrhea, galactorrhea, elevated serum hPRL, and roentgenographic evidence of an enlarged sella turcica. Pneumoencephalography with hypocycloidal polytomography is interpreted as both an empty sella, and evidence of a pituitary adenoma. The etiology and endocrine findings in the empty sella syndrome are discussed.[1]


  1. Galactorrhea, amenorrhea, hyperprolactinemia, and an empty sella. Archer, D.F., Maroon, J.C., DuBois, P.J. Obstetrics and gynecology. (1978) [Pubmed]
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