The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sella Turcica

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sella Turcica

  • In patients with moderate hypothyroidism and moderate enlargement of the sella turcica, T4 (2.0 micrograms/kg BW) normalized serum T4, T3, and basal TSH concentrations but failed to normalize TRH-stimulated TSH levels [1].
  • The patient's insulin-like growth factor-1 (IGF-1) level was elevated at 462 microg/L, whereas a magnetic resonance image of the sella turcica revealed an intra- and suprasellar lesion that was compatible with a diagnosis of pituitary adenoma [2].
  • Between 1980 and 1986, 58 patients (23 women and 35 men) had coronal CT scans of the sella turcica for suspected growth hormone-secreting adenoma and underwent transsphenoidal exploration [3].
  • Hyperprolactinemia, hypogonadotropinism, and subnormal plasma testosterone were found in a 65-year-old patient who had an enlarged sella turcica, complained of fatigue, and addmitted to decreased sexual interest and potency [4].
  • The present case details a young woman with amenorrhea, galactorrhea, elevated serum hPRL, and roentgenographic evidence of an enlarged sella turcica [5].

High impact information on Sella Turcica

  • Radiological findings of an enlarged sella turcica with displacement of the pituitary stalk were considered consistent with a prolactin macroadenoma [6].
  • Thus, at the present time, metrizamide cisternography (especially in conjunction with CT scanning) appears useful in evaluating an enlarged sella turcica, particularly when considering an entity such as ESS [7].
  • Postpartum, her evaluation included normal thyroid function studies, a normal thyroid-stimulating hormone response to protirelin (thyrotropin-releasing hormone), normal serum and urine gonadotropin levels, normal serum prolactin, normal sella turcica tomograms, and a normal EMI brain scan [8].
  • We conclude that 1) a large sella turcica and an enlarged pituitary anterior lobe with hyperintense enhanced signal at T1 at MRI can be suggestive of PROP1 deficiency; 2) pituitary morphology can change during follow-up of patients with PROP1 gene mutation; and 3) hormonal deficiencies could include the adrenal axis [9].
  • Of these 16 patients, 4 had a normal sella turcica (ST; group STO), 4 had a slight enlargement (group ST+), and 7 had a clear enlargement of ST (ST++) but no evidence of suprasellar extension [10].

Chemical compound and disease context of Sella Turcica


Biological context of Sella Turcica

  • From October 2001 to the end of November 2002 in Department of Neurosurgery, Silesian University School of Medicine in Katowice 70 explorations of the sella turcica were executed using the endoscopic method [16].
  • Thus, the reduction in serum PRL after pregnancy, delivery and lactation was considered to be the result of a decrease in the size of the adenoma due to adenoma enlargement over the sella turcica through the estrogen effects during pregnancy, and from impairment of pituitary circulation [17].

Anatomical context of Sella Turcica


Associations of Sella Turcica with chemical compounds

  • Four years after irradiation, the plasma adrenocorticotropic hormone (ACTH) concentration was elevated, but tomography of the sella turcica and urinary cortisol excretion remained normal [23].
  • Size-adjustable titanium plate for reconstruction of the sella turcica. Technical note [24].
  • Sella turcica tomography, base line serum follicle-stimulating hormone, luteinizing hormone (LH), thyroid-stimulating hormone, T4, plasma cortisol levels, and the growth hormone reserve were normal in all patients [25].
  • These studies included polytomography of the sella turcica; dynamic pituitary testing of growth hormone reserve, adrenocorticotropic hormone reserve, and gonadotropin reserve; and prolactin suppression with L-dopa [26].
  • Between 1980 and 1985, 35 patients (26 women and nine men) who had coronal CT scans of the sella turcica for suspected ACTH-secreting pituitary adenoma underwent transsphenoidal exploration [27].

Gene context of Sella Turcica


Analytical, diagnostic and therapeutic context of Sella Turcica


  1. Difference in pituitary-thyroid feedback regulation in hypothyroid patients, depending on the severity of hypothyroidism. Aizawa, T., Koizumi, Y., Yamada, T., Tawata, M., Nagata, H., Izumiyama, T., Yoshizawa, K. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  2. Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study. Case report. Losa, M., Saeger, W., Mortini, P., Pandolfi, C., Terreni, M.R., Taccagni, G., Giovanelli, M. J. Neurosurg. (2000) [Pubmed]
  3. Diagnostic accuracy of preoperative CT scanning of pituitary somatotroph adenomas. Marcovitz, S., Wee, R., Chan, J., Hardy, J. AJNR. American journal of neuroradiology. (1988) [Pubmed]
  4. Divorce and remarriage in a 65-year-old male following transphenoidal surgery and bromocriptine of hyperprolactinemic impotence: a dilemma. Tolis, G., Bertrand, G., Pinter, E. Psychosomatic medicine. (1979) [Pubmed]
  5. Galactorrhea, amenorrhea, hyperprolactinemia, and an empty sella. Archer, D.F., Maroon, J.C., DuBois, P.J. Obstetrics and gynecology. (1978) [Pubmed]
  6. Sellar enlargement with hyperprolactinemia and a Rathke's pouch cyst. Trokoudes, K.M., Walfish, P.G., Holgate, R.C., Pritzker, K.P., Schwartz, M.L., Kovacs, K. JAMA (1978) [Pubmed]
  7. Metrizamide cisternography in the investigation of the empty sella syndrome. Zull, D.N., Falko, J.M. Arch. Intern. Med. (1981) [Pubmed]
  8. Hypoglycemia in pregnancy. Occurrence due to adrenocorticotropic hormone and growth hormone deficiency. Smallridge, R.C., Corrigan, D.F., Thomason, A.M., Blue, P.W. Arch. Intern. Med. (1980) [Pubmed]
  9. Longitudinal hormonal and pituitary imaging changes in two females with combined pituitary hormone deficiency due to deletion of A301,G302 in the PROP1 gene. Mendonca, B.B., Osorio, M.G., Latronico, A.C., Estefan, V., Lo, L.S., Arnhold, I.J. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  10. Normal pregnancies after treatment of hyperprolactinemia with bromoergocryptine, despite suspected pituitary tumors. Mornex, R., Orgiazzi, J., Hugues, B., Gagnaire, J.C., Claustrat, B. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  11. Sellar reconstruction with resorbable vicryl patches, gelatin foam, and fibrin glue in transsphenoidal surgery: a 10-year experience with 376 patients. Seiler, R.W., Mariani, L. J. Neurosurg. (2000) [Pubmed]
  12. Nomifensine test does not differentiate hyperprolactinemia associated with and without radiologic abnormalities in the sella turcica. Canales, E.S., Cano, C., Ablanedo, J., Zárate, A. Horm. Res. (1981) [Pubmed]
  13. Skull base erosion by sphenoid fungus balls: diagnosis and endoscopic treatment. Schlosser, R.J., Gross, C.W., Kountakis, S. American journal of rhinology. (2002) [Pubmed]
  14. Functional evaluation of the adenohypophysis with metoclopramide in hyperprolactinemic-amenorrheic women in relation to radiological findings on the sella turcica. Seki, K., Uesato, T., Kato, K., Shima, K. Endocrinol. Jpn. (1984) [Pubmed]
  15. Syndrome of inappropriate antidiuretic hormone secretion in a patient with intrasellar neurofibroma of the sixth nerve. Char, G., Charles, C.F., Moule, N.J., Lyn, C. The West Indian medical journal. (1991) [Pubmed]
  16. Endoscopic transnasal transsphenoidal treatment of pathology of the sellar region. Rudnik, A., Zawadzki, T., Wojtacha, M., Bazowski, P., Gamrot, J., Galuszka-Ignasiak, B., Duda, I. Minimally invasive neurosurgery : MIN. (2005) [Pubmed]
  17. Effects of pregnancy, delivery and lactation in hyperprolactinemia with prolactin producing pituitary adenoma. Kondo, I., Suganuma, N., Kimura, T., Matsuzawa, K., Osawa, M., Masahashi, T., Mizutani, S., Narita, O., Tomoda, Y. Nippon Sanka Fujinka Gakkai Zasshi (1989) [Pubmed]
  18. VSX1 (RINX) mutation with craniofacial anomalies, empty sella, corneal endothelial changes, and abnormal retinal and auditory bipolar cells. Mintz-Hittner, H.A., Semina, E.V., Frishman, L.J., Prager, T.C., Murray, J.C. Ophthalmology (2004) [Pubmed]
  19. Diagnosis of the empty sella with intrathecal metrizamide computed tomography. Price, M.J., Corbett, J.J., Thompson, H.S. Survey of ophthalmology. (1983) [Pubmed]
  20. The increase in the cardiodepressant activity and vasopressin concentration in the sella turcica venous blood during vagal afferents stimulation or after angiotensin II infusion. Goraca, A., Orłowska-Majdak, M., Traczyk, W.Z. J. Physiol. Pharmacol. (1996) [Pubmed]
  21. Ocular and endocrine function in patients with pituitary tumors. Operative results following transnasal, transsphenoidal approach with marsupialization of the sella turcica. Dagi, T.F., Kattah, J.C. The American surgeon. (1986) [Pubmed]
  22. Increase in oxytocin and vasopressin concentration in the blood outflowing from sella turcica region after superior cervical ganglion stimulation in rat. Lipińska, S., Orłowska-Majdak, M., Traczyk, W.Z. J. Physiol. Pharmacol. (1996) [Pubmed]
  23. Recurrent Cushing's disease: successful treatment by pituitary irradiation or trans-sphenoidal hypophysectomy in two cases. Caplan, R.H., Annis, B.L. Neurosurgery (1980) [Pubmed]
  24. Size-adjustable titanium plate for reconstruction of the sella turcica. Technical note. Arita, K., Kurisu, K., Tominaga, A., Ikawa, F., Iida, K., Hama, S., Watanabe, H. J. Neurosurg. (1999) [Pubmed]
  25. Treatment of functional amenorrhea-galactorrhea with 2-bromoergocryptine. Wiebe, R.H., Hammond, C.B., Handwerger, S. Fertil. Steril. (1977) [Pubmed]
  26. Prolactin-secreting pituitary microadenoma: detection and evaluation. Wiebe, R.H., Hammond, C.B., Handwerger, S. Fertil. Steril. (1978) [Pubmed]
  27. The diagnostic accuracy of preoperative CT scanning in the evaluation of pituitary ACTH-secreting adenomas. Marcovitz, S., Wee, R., Chan, J., Hardy, J. AJR. American journal of roentgenology. (1987) [Pubmed]
  28. The use of thyrotropin-releasing hormone in distinguishing prolactin-secreting pituitary adenoma. Marrs, R.P., Bertolli, S.J., Kletzky, O.A. Am. J. Obstet. Gynecol. (1980) [Pubmed]
  29. The growth hormone, prolactin and TSH response to TRH and L-dopa in patients with hyperprolactinaemia and a normal-sized sella turcica may denote a pituitary adenoma. Brismar, K., Hulting, A.L., Werner, S. J. Intern. Med. (1990) [Pubmed]
  30. Prolactin and thyroid-stimulating hormone responses to thyrotropin-releasing hormone in cases of hyperprolactinemia with normal and abnormal sella tomograms. Badawy, S.Z., Moses, A., Streeten, D., Marshall, L., Marlin, D., Notman, D. Int. J. Fertil. (1983) [Pubmed]
  31. ACTH deficiency and TSH hypersecretion in a patient with empty sella turcica. Komatsu, M., Aizawa, T., Shinoda, T., Yamada, T., Mochizuki, T. Am. J. Med. Sci. (1989) [Pubmed]
  32. Inconsistent stimulation of plasma ACTH through corticotropin-releasing factor in a patient with central Cushing's disease due to pituitary adenoma. Rohrmoser, B., Lüdecke, D.K., Scriba, P.C. Klin. Wochenschr. (1985) [Pubmed]
  33. Phlebography of the sella turcica by a trans-sphenoidal technique. Pilot experiments in cadavers. Tvete, S., Mørk, S.J. European journal of radiology. (1982) [Pubmed]
  34. Computer-assisted frameless stereotaxy in transsphenoidal surgery at a single institution: review of 176 cases. Jagannathan, J., Prevedello, D.M., Ayer, V.S., Dumont, A.S., Jane, J.A., Laws, E.R. Neurosurgical focus [electronic resource]. (2006) [Pubmed]
  35. ACTH-producing pituitary adenomas in Addison's disease: two cases treated by transsphenoidal microsurgery. Krautli, B., Müller, J., Landolt, A.M., von Schulthess, F. Acta Endocrinol. (1982) [Pubmed]
WikiGenes - Universities