Disease relevance of Empty Sella Syndrome

• Diurnal variation of prolactin secretion differentiates pituitary tumors from the primary empty sella syndrome [1].
• Three patients with chromophobe adenomas had normal serum PRL concentrations and elevated CSF prolactin levels which differentiated them from fifteen patients with the primary empty sella syndrome who had normal serum and CSF prolactin levels [2].
• The empty-sella syndrome should be included among the causes of arginine-vasopressin deficient diabetes insipidus in pediatric patients [3].
• A chronobiological study was carried out in pituitary GH- and PRL-secreting adenomas and in the empty sella syndrome [4].
• We also present several features present in one of the siblings, viz., microcephaly, microstomia, clinodactylyl, brachydactylyl, empty sella syndrome and severe hypoplasia of the right internal carotid vessels associated with mild narrowing of the left internal carotid artery which have not been previously described [5].

High impact information on Empty Sella Syndrome

• The primary empty sella syndrome. Diagnosis with metrizamide cisternography [6].
• Primary empty sella syndrome with CSF rhinorrhea [7].
• This report describes two unique patients with ACTH hypersecretion, primary empty sella syndrome, and normal cortisol dynamics [8].
• The 22-year-old male patient with the empty sella syndrome has progressed through puberty after the addition of oral testosterone [9].
• A 45 kDa pituitary specific membrane protein was identified as an autoantigen in one of 19 patients with idiopathic growth hormone deficiency and the empty sella syndrome [10].

Chemical compound and disease context of Empty Sella Syndrome

• Dissociation of serum prolactin response to sequential thyrotropin-releasing hormone and chlorpromazine stimulation in patients with primary empty sella syndrome [11].
• GH secretion was studied in 47 patients with empty sella syndrome (ESS), using the GH response to the L-dopa test and determinations of the somatomedin levels [12].
• TSH and prolactin responses to thyrotropin releasing hormone (TRH) and domperidone in patients with empty sella syndrome [13].
• We describe a first case of a twin pregnancy in a 36-year-old patient presenting with primary hypogonadotropic amenorrhea and empty sella syndrome and treated with recombinant FSH and LH [14].

Anatomical context of Empty Sella Syndrome

• In only one case there was a radiological abnormality of the sella turcica; this patient had an empty sella syndrome and a raised serum prolactin value [15].
• Cerebrospinal fluid pressure and prolactin in empty sella syndrome [16].
• Pneumotomo-encephalography revealed a large arachnoid herniation, leading to the diagnosis of primary empty sella turcica syndrome with secondary panhypopituitarism [17].

Gene context of Empty Sella Syndrome

• In summary, like other anterior pituitary hormones, the pituitary reserve in "empty sella syndrome" of hTSH and hPRL is usually normal [18].
• METHODS: A total of 12 healthy persons and 20 patients with pituitary disorder were recruited, including 6 with Sheehan's syndrome, 6 with idiopathic panhypopituitarism, 3 with isolated ACTH deficiency, 2 with pituitary apoplexy, 2 with empty sella syndrome and I with postoperative suprasellar tumor [19].
• Short stature and low IGF-1 and IGFBP-3 despite normal growth hormone secretion in a 4 year-old girl with primary empty sella syndrome [20].
• Growth hormone deficiency and empty sella syndrome in a boy with dup(X) (q13.3----q21.2) [21].
• Association of empty sella syndrome and primary hyperparathyroidism [22].

References