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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Folic acid, mental function, and dietary habits.

The combination of biochemical theory, case studies, and patient population surveys suggests that the water soluble vitamin, folic acid, is relevant to mental functions. Several studies demonstrate a clinical correlation between folate deficiency and psychiatric hospitalization. The role of dietary deficiency to these observations has needed further examination. After reviewing the serum folate values of 269 psychiatric hospital admissions, the incidence of serum folates below 5.9 ng./ml. was found to be greater than a control group. A dietary rating for all admissions revealed a high frequency of deficiency in all patients with no greater prevalence among the low folate group. These observations agree that psychiatric patients are more likely to have low serum folate values, and suggest that poor diet does not explain the increased likelihood.[1]


  1. Folic acid, mental function, and dietary habits. Thornton, W.E., Thornton, B.P. The Journal of clinical psychiatry. (1978) [Pubmed]
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