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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Propoxyphene form maintenance treatment of narcotic addiction.

Two studies compared propoxyphene napsylate (Darvon-N) with methadone hydrochloride as maintenance treatment for narcotic addicts. Most measures indicated that methadone was more effective than propoxyphene as a maintenance drug. Patients receiving propoxyphene reported more withdrawal-related symptoms early in treatment, tended to drop out sooner than patients receiving methadone, and were more likely to abuse heroin. Nevertheless, follow-up interviews at one and six months after treatment indicated no between-group differences in adjustment.[1]


  1. Propoxyphene form maintenance treatment of narcotic addiction. Woody, G.E., Mintz, J., Tennant, F., O'Brien, C.P., McLellan, A.T., Marcovici, M. Arch. Gen. Psychiatry (1981) [Pubmed]
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