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Chemical Compound Review

propoxyphene     [(2S,3R)-4-dimethylamino-3- methyl-1,2...

Synonyms: Antalvic, Proxyvon, Algafan, Femadol, Proxyphen, ...
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Disease relevance of propoxyphene


Psychiatry related information on propoxyphene


High impact information on propoxyphene


Chemical compound and disease context of propoxyphene


Biological context of propoxyphene


Anatomical context of propoxyphene


Associations of propoxyphene with other chemical compounds


Gene context of propoxyphene


Analytical, diagnostic and therapeutic context of propoxyphene


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  2. Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine. Whitcomb, D.C., Gilliam, F.R., Starmer, C.F., Grant, A.O. J. Clin. Invest. (1989) [Pubmed]
  3. Low free serum histidine concentration in rheumatoid arthritis. A measure of disease activity. Gerber, D.A. J. Clin. Invest. (1975) [Pubmed]
  4. Dextropropoxyphene induced hepatotoxicity mimicking biliary tract disease. Bassendine, M.F., Woodhouse, K.W., Bennett, M., James, O.F. Gut (1986) [Pubmed]
  5. Therapeutic usefulness of propoxyphene napsylate in narcotic addiction. Jasinski, D.R., Pevnick, J.S., Clark, S.C., Griffith, J.D. Arch. Gen. Psychiatry (1977) [Pubmed]
  6. Propoxyphene form maintenance treatment of narcotic addiction. Woody, G.E., Mintz, J., Tennant, F., O'Brien, C.P., McLellan, A.T., Marcovici, M. Arch. Gen. Psychiatry (1981) [Pubmed]
  7. A controlled trial of propoxyphene and naltrexone in patients with Tourette's syndrome. Kurlan, R., Majumdar, L., Deeley, C., Mudholkar, G.S., Plumb, S., Como, P.G. Ann. Neurol. (1991) [Pubmed]
  8. The cognitive and psychomotor effects of morphine in healthy subjects: a randomized controlled trial of repeated (four) oral doses of dextropropoxyphene, morphine, lorazepam and placebo. O'Neill, W.M., Hanks, G.W., Simpson, P., Fallon, M.T., Jenkins, E., Wesnes, K. Pain (2000) [Pubmed]
  9. A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene. Kaplan, P.W., Allen, R.P., Buchholz, D.W., Walters, J.K. Sleep. (1993) [Pubmed]
  10. Propoxyphene napsylate. Lasagna, L. Ann. Intern. Med. (1976) [Pubmed]
  11. Propoxyphene and acetaminophen mixture (Darvocet)--related radiation-induced pneumonitis. Halpern, J., Baerwald, H., Johnson, R., Takita, H., Ambrus, J.L. Arch. Intern. Med. (1985) [Pubmed]
  12. Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient. Gibson, T.P., Giacomini, K.M., Briggs, W.A., Whitman, W., Levy, G. Clin. Pharmacol. Ther. (1980) [Pubmed]
  13. Pharmacokinetics of opioids in renal dysfunction. Davies, G., Kingswood, C., Street, M. Clinical pharmacokinetics. (1996) [Pubmed]
  14. Acute effect of ethanol on hepatic first-pass elimination of propoxyphene in rats. Oguma, T., Levy, G. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  15. Co-proxamol and suicide: preventing the continuing toll of overdose deaths. Simkin, S., Hawton, K., Sutton, L., Gunnell, D., Bennewith, O., Kapur, N. QJM : monthly journal of the Association of Physicians. (2005) [Pubmed]
  16. d-Propoxyphene kinetics after single oral and intravenous doses in man. Gram, L.F., Schou, J., Way, W.L., Heltberg, J., Bodin, N.O. Clin. Pharmacol. Ther. (1979) [Pubmed]
  17. Propoxyphene and norpropoxyphene: influence of diet and fluid on plasma levels. Welling, P.G., Lyons, L.L., Tse, F.L., Craig, W.A. Clin. Pharmacol. Ther. (1976) [Pubmed]
  18. Nefopam and propoxyphene in episiotomy pain. Bloomfield, S.S., Barden, T.P., Mitchell, J. Clin. Pharmacol. Ther. (1980) [Pubmed]
  19. Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients. Giacomini, K.M., Gibson, T.P., Levy, G. Clin. Pharmacol. Ther. (1980) [Pubmed]
  20. Excretion of propoxyphene and norpropoxyphene in breast milk. Kunka, R.L., Venkataramanan, R., Stern, R.M., Ladik, C.F. Clin. Pharmacol. Ther. (1984) [Pubmed]
  21. Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents. Ulens, C., Daenens, P., Tytgat, J. Cardiovasc. Res. (1999) [Pubmed]
  22. Propoxyphene and norpropoxyphene: pharmacologic and toxic effects in animals. Nickander, R., Smits, S.E., Steinberg, M.I. J. Pharmacol. Exp. Ther. (1977) [Pubmed]
  23. Methadone block of K+ current in squid giant fiber lobe neurons. Horrigan, F.T., Gilly, W.F. J. Gen. Physiol. (1996) [Pubmed]
  24. Hemodialysis in an infant with propoxyphene intoxication. Mauer, S.M., Paxson, C.L., von Hartizsch, B., Buselmeier, T.J., Kjellstrand, C.M. Clin. Pharmacol. Ther. (1975) [Pubmed]
  25. New clinical experience with tramadol. Sunshine, A. Drugs (1994) [Pubmed]
  26. CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement. Somogyi, A.A., Menelaou, A., Fullston, S.V. Xenobiotica (2004) [Pubmed]
  27. Profound metoprolol-induced bradycardia precipitated by acetaminophen-propoxyphene. Marraffa, J.M., Lang, L., Ong, G., Lehmann, D.F. Clin. Pharmacol. Ther. (2006) [Pubmed]
  28. Phenotype/genotype relationships for the cytochrome P450 enzyme CYP2D6 in rheumatoid arthritis: influence of drug therapy and disease activity. Beyeler, C., Daly, A.K., Armstrong, M., Astbury, C., Bird, H.A., Idle, J.R. J. Rheumatol. (1994) [Pubmed]
  29. Single-patient data meta-analysis of 3453 postoperative patients: oral tramadol versus placebo, codeine and combination analgesics. Moore, R.A., McQuay, H.J. Pain (1997) [Pubmed]
  30. Determination of propoxyphene and norpropoxyphene by chemical ionization mass fragmentography. Wolen, R.L., Ziege, E.A., Gruber, C.M. Clin. Pharmacol. Ther. (1975) [Pubmed]
  31. Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt. Giacomini, K.M., Giacomini, J.C., Gibson, T.P., Levy, G. Clin. Pharmacol. Ther. (1980) [Pubmed]
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