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MeSH Review

Opioid-Related Disorders

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Disease relevance of Opioid-Related Disorders


Psychiatry related information on Opioid-Related Disorders


High impact information on Opioid-Related Disorders


Chemical compound and disease context of Opioid-Related Disorders


Biological context of Opioid-Related Disorders


Anatomical context of Opioid-Related Disorders


Gene context of Opioid-Related Disorders

  • This study reveals a cardinal role for CRF/CRF1 receptor pathways in the negative affective states of opiate withdrawal and suggests therapeutic strategies for the treatment of opiate addiction [28].
  • Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence [21].
  • The abnormalities of MAPK signalling might have important consequences in the long term development of various forms of neural plasticity associated with opiate addiction in humans [29].
  • The authors describe the use of moclobemide in a 27-year-old patient with comorbid opiate addiction and ADHD (residual type) [30].
  • In contrast to data obtained in adult animals, NMDA receptor antagonists are neither effective in blocking the development of opiate dependence nor the expression of opiate withdrawal in neonatal rats [31].

Analytical, diagnostic and therapeutic context of Opioid-Related Disorders


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  18. CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. Lane-Ladd, S.B., Pineda, J., Boundy, V.A., Pfeuffer, T., Krupinski, J., Aghajanian, G.K., Nestler, E.J. J. Neurosci. (1997) [Pubmed]
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  20. Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation. Ferrer-Alcón, M., La Harpe, R., Guimón, J., García-Sevilla, J.A. Neuropsychopharmacology (2003) [Pubmed]
  21. Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence. Tyndale, R.F., Droll, K.P., Sellers, E.M. Pharmacogenetics (1997) [Pubmed]
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  26. Long-lasting reciprocal changes in striatal dopamine and acetylcholine release upon morphine withdrawal. Tjon Tien Ril, H.K., De Vries, T.J., Wardeh, G., Hogenboom, F., Mulder, A.H., Schoffelmeer, A.N. Eur. J. Pharmacol. (1993) [Pubmed]
  27. Cyclophosphamide and cortisol reduce the severity of morphine withdrawal. Montgomery, S.P., Dafny, N. Int. J. Immunopharmacol. (1987) [Pubmed]
  28. The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal. Contarino, A., Papaleo, F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  29. Long-term regulation of signalling components of adenylyl cyclase and mitogen-activated protein kinase in the pre-frontal cortex of human opiate addicts. Ferrer-Alcón, M., J García-Fuster, M., La Harpe, R., García-Sevilla, J.A. J. Neurochem. (2004) [Pubmed]
  30. Treatment of comorbid opiate addiction and attention-deficit hyperactivity disorder (residual type) with moclobemide: a case report. Vaiva, G., De Lenclave, M.B., Bailly, D. Prog. Neuropsychopharmacol. Biol. Psychiatry (2002) [Pubmed]
  31. Opiate physical dependence and N-methyl-D-aspartate receptors. Noda, Y., Nabeshima, T. Eur. J. Pharmacol. (2004) [Pubmed]
  32. Increased density of guanine nucleotide-binding proteins in the postmortem brains of heroin addicts. Escriba, P.V., Sastre, M., Garcia-Sevilla, J.A. Arch. Gen. Psychiatry (1994) [Pubmed]
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  36. Effects of 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) on the self-administration of cocaine, heroin, and cocaine/heroin combinations in rats. Sizemore, G.M., Davies, H.M., Martin, T.J., Smith, J.E. Drug and alcohol dependence. (2004) [Pubmed]
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