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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Neuroleptic malignant syndrome. Patient with unique clinical and physiologic features.

Lethargy, marked muscle weakness and rigidity, a maximal temperature of 40 degrees C, and a maximal creatine kinase value of 17,240 IU/liter developed in a 36-year-old woman following treatment with several neuroleptics. Initial treatment with dantrolene was unsuccessful. The patient's condition improved gradually over a 10-day period with no specific therapy. Muscle biopsy revealed a contracture pattern diagnostic of malignant hyperthermia susceptibility, as well as abnormal sensitivity to fluphenazine. This report may be the first description of a patient with neuroleptic malignant syndrome in whom muscle biopsy response similar to that seen in malignant hyperthermia occurred and documents that dantrolene is not uniformly successful therapy for this syndrome.[1]

References

  1. Neuroleptic malignant syndrome. Patient with unique clinical and physiologic features. Downey, G.P., Rosenberg, M., Caroff, S., Beck, S., Rosenberg, H., Gerber, J.C., Heiman-Patterson, T.D., Aronson, M.D. Am. J. Med. (1984) [Pubmed]
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