The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN56848     1-[[5-(4-nitrophenyl)-2...

Synonyms: KBioGR_000025, KBioGR_000645, KBioSS_000025, KBioSS_002017, CBiol_001748, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of dantrolene


Psychiatry related information on dantrolene


High impact information on dantrolene


Chemical compound and disease context of dantrolene


Biological context of dantrolene

  • Phosphorylation of all NARPPs was eliminated by dantrolene, which inhibits release of calcium from intracellular stores [19].
  • Identification of dantrolene binding sites in porcine skeletal muscle sarcoplasmic reticulum [20].
  • To explore its mechanism of action, the effect of dantrolene on MH-like channel activation by the synthetic domain peptide DP4 or anti-DP4 antibody was examined [21].
  • In an insult that exhibited secondary energy failure and apoptosis we identified a relative 25% augmentation of high-energy phosphates at the end of recovery when the ryanodine-receptor antagonist, dantrolene, was introduced in the early (0- to 40-minute) but not late (40- to 120-minute) stage of recovery (P < 0.05) [22].
  • Early postischemic dantrolene-induced amelioration of poly(ADP-ribose) polymerase-related bioenergetic failure in neonatal rat brain slices [22].

Anatomical context of dantrolene


Associations of dantrolene with other chemical compounds

  • The release of Ca2+ from this pool is sensitive to the skeletal muscle relaxant dantrolene, and this may constitute a novel and alternative therapeutic approach against NMDA receptor-mediated excitotoxicity [28].
  • In contrast, cardiac sarcoplasmic reticulum vesicle 45Ca2+ release and [3H]ryanodine binding were unaffected by dantrolene [29].
  • Because dantrolene strongly inhibited glucose-stimulated insulin secretion (from 3.07 +/- 0.51-fold stimulation to no significant glucose effect; n = 3, p < 0.01), we conclude that RyR I-mediated Ca(2+)-induced Ca(2+) release from secretory vesicles, possibly potentiated by NAADP, is essential for the activation of insulin secretion [25].
  • Because 2-APB inhibits hyphal growth and dissipates the tip-high cytosolic [Ca(2+)] gradient, whereas heparin microinjection, TMB-8 and dantrolene treatments do not affect growth, we suggest that the small conductance channel generates the obligatory tip-high Ca(2+) gradient during hyphal growth [30].
  • [3H]-ryanodine binding in total membranes was enhanced by AMP-PCP, caffeine and xanthine, whereas Mg2+, Ruthenium Red and dantrolene were inhibitors [31].

Gene context of dantrolene

  • However, the molecular basis and specificity of the actions of dantrolene on RYR channels have remained in question [32].
  • In contrast to the RYR1 isoform, the cardiac RYR2 isoform was unaffected by dantrolene, both in native cardiac SR vesicles and when heterologously expressed in HEK-293 cells [32].
  • Our results thus indicate that both the RYR1 and the RYR3, but not the RYR2, may be targets for dantrolene inhibition in vivo [32].
  • Dantrolene decreased TNF-alpha in lung (26.1%), liver (29.4%), and spleen (35.4%) (p < .05) and IL-1 alpha in lung (30.0%) and liver (25.4%) (p < .05) [33].
  • In addition, both ruthenium red and dantrolene had a strong inhibitory effect on IL-2-dependent proliferation of CTLL-2 T cells [34].

Analytical, diagnostic and therapeutic context of dantrolene


  1. Treatment of heat stroke with dantrolene. Lydiatt, J.S., Hill, G.E. JAMA (1981) [Pubmed]
  2. Dantrolene, pelvic neoplasm, and muscle spasms: report of a case. Myers, A. JAMA (1977) [Pubmed]
  3. Letter: Treatment of spasticity in multiple sclerosis with dantrolene. Horne, M.L. JAMA (1976) [Pubmed]
  4. Letter: Dantrolene in amyotrophic lateral sclerosis. Rivera, V.M., Breitbach, W.B., Swanke, L. JAMA (1975) [Pubmed]
  5. Treatment of neuroleptic malignant syndrome with dantrolene. Goekoop, J.G., Carbaat, P.A. Lancet (1982) [Pubmed]
  6. Dantrolene in lethal catatonia. Pennati, A., Sacchetti, E., Calzeroni, A. The American journal of psychiatry. (1991) [Pubmed]
  7. Neuroleptic malignant syndrome. Review of response to therapy. Rosenberg, M.R., Green, M. Arch. Intern. Med. (1989) [Pubmed]
  8. Treatment of lethal catatonia with electroconvulsive therapy and dantrolene sodium: a case report. Nolen, W.A., Zwaan, W.A. Acta psychiatrica Scandinavica. (1990) [Pubmed]
  9. Letter: Hallucinations associated with dantrolene sodium therapy. Andrews, L.G., Muzumdar, A.S., Pinkerton, A.C. Canadian Medical Association journal. (1975) [Pubmed]
  10. Calcium release from skeletal muscle sarcoplasmic reticulum: site of action of dantrolene sodium. Van Winkle, W.B. Science (1976) [Pubmed]
  11. Letter: Dantrolene deposited in connective tissue. Wilkie, O.L. JAMA (1976) [Pubmed]
  12. Ca2+ homeostasis in Brody's disease. A study in skeletal muscle and cultured muscle cells and the effects of dantrolene an verapamil. Benders, A.A., Veerkamp, J.H., Oosterhof, A., Jongen, P.J., Bindels, R.J., Smit, L.M., Busch, H.F., Wevers, R.A. J. Clin. Invest. (1994) [Pubmed]
  13. Myoplasmic Ca2+ concentration during exertional rhabdomyolysis. López, J.R., Rojas, B., Gonzalez, M.A., Terzic, A. Lancet (1995) [Pubmed]
  14. Azumolene Inhibits a Component of Store-operated Calcium Entry Coupled to the Skeletal Muscle Ryanodine Receptor. Zhao, X., Weisleder, N., Han, X., Pan, Z., Parness, J., Brotto, M., Ma, J. J. Biol. Chem. (2006) [Pubmed]
  15. Phenelzine toxicity responsive to dantrolene. Verrilli, M.R., Salanga, V.D., Kozachuk, W.E., Bennetts, M. Neurology (1987) [Pubmed]
  16. Intravenous injection of levodopa is more effective than dantrolene as therapy for neuroleptic malignant syndrome. Nisijima, K., Noguti, M., Ishiguro, T. Biol. Psychiatry (1997) [Pubmed]
  17. Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons. Frandsen, A., Schousboe, A. J. Neurochem. (1993) [Pubmed]
  18. Dantrolene prevents glutamate cytotoxicity and Ca2+ release from intracellular stores in cultured cerebral cortical neurons. Frandsen, A., Schousboe, A. J. Neurochem. (1991) [Pubmed]
  19. NMDA receptor activation-responsive phosphoproteins in the developing optic tectum. Scheetz, A.J., Constantine-Paton, M. J. Neurosci. (1996) [Pubmed]
  20. Identification of dantrolene binding sites in porcine skeletal muscle sarcoplasmic reticulum. Parness, J., Palnitkar, S.S. J. Biol. Chem. (1995) [Pubmed]
  21. Dantrolene stabilizes domain interactions within the ryanodine receptor. Kobayashi, S., Bannister, M.L., Gangopadhyay, J.P., Hamada, T., Parness, J., Ikemoto, N. J. Biol. Chem. (2005) [Pubmed]
  22. Early postischemic dantrolene-induced amelioration of poly(ADP-ribose) polymerase-related bioenergetic failure in neonatal rat brain slices. Tasker, R.C., Sahota, S.K., Cotter, F.E., Williams, S.R. J. Cereb. Blood Flow Metab. (1998) [Pubmed]
  23. Antispasticity drugs: mechanisms of action. Davidoff, R.A. Ann. Neurol. (1985) [Pubmed]
  24. Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation. Schneider, I., Reverse, D., Dewachter, I., Ris, L., Caluwaerts, N., Kuiperi, C., Gilis, M., Geerts, H., Kretzschmar, H., Godaux, E., Moechars, D., Van Leuven, F., Herms, J. J. Biol. Chem. (2001) [Pubmed]
  25. Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). Mitchell, K.J., Lai, F.A., Rutter, G.A. J. Biol. Chem. (2003) [Pubmed]
  26. Ultraviolet light activates blocking actions of dantrolene on intracellular Ca2+ release in bullfrog sympathetic neurones. Nohmi, M., Kuba, K., Hua, S.Y. J. Biol. Chem. (1991) [Pubmed]
  27. The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways. Kojima, I., Kojima, K., Kreutter, D., Rasmussen, H. J. Biol. Chem. (1984) [Pubmed]
  28. NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release. Mody, I., MacDonald, J.F. Trends Pharmacol. Sci. (1995) [Pubmed]
  29. Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors. Fruen, B.R., Mickelson, J.R., Louis, C.F. J. Biol. Chem. (1997) [Pubmed]
  30. An IP3-activated Ca2+ channel regulates fungal tip growth. Silverman-Gavrila, L.B., Lew, R.R. J. Cell. Sci. (2002) [Pubmed]
  31. Biochemical characterization, distribution and phylogenetic analysis of Drosophila melanogaster ryanodine and IP3 receptors, and thapsigargin-sensitive Ca2+ ATPase. Vázquez-Martínez, O., Cañedo-Merino, R., Díaz-Muñoz, M., Riesgo-Escovar, J.R. J. Cell. Sci. (2003) [Pubmed]
  32. Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. Zhao, F., Li, P., Chen, S.R., Louis, C.F., Fruen, B.R. J. Biol. Chem. (2001) [Pubmed]
  33. Calcium antagonists decrease plasma and tissue concentrations of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-1 alpha in a mouse model of endotoxin. Hotchkiss, R.S., Osborne, D.F., Lappas, G.D., Karl, I.E. Shock (1995) [Pubmed]
  34. Ryanodine receptor signaling is required for anti-CD3-induced T cell proliferation, interleukin-2 synthesis, and interleukin-2 receptor signaling. Conrad, D.M., Hanniman, E.A., Watson, C.L., Mader, J.S., Hoskin, D.W. J. Cell. Biochem. (2004) [Pubmed]
  35. Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. Hotchkiss, R.S., Karl, I.E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  36. Hepatitis from dantrolene sodium. Wilkinson, S.P., Portmann, B., Williams, R. Gut (1979) [Pubmed]
  37. Characterization of metabotropic glutamate receptor-mediated nitric oxide production in vivo. Bhardwaj, A., Northington, F.J., Martin, L.J., Hanley, D.F., Traystman, R.J., Koehler, R.C. J. Cereb. Blood Flow Metab. (1997) [Pubmed]
  38. Resolution of neuroleptic malignant syndrome with dantrolene sodium: case report. Khan, A., Jaffe, J.H., Nelson, W.H., Morrison, B. The Journal of clinical psychiatry. (1985) [Pubmed]
WikiGenes - Universities