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MeSH Review

Malignant Hyperthermia

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Disease relevance of Malignant Hyperthermia


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High impact information on Malignant Hyperthermia


Chemical compound and disease context of Malignant Hyperthermia


Biological context of Malignant Hyperthermia


Anatomical context of Malignant Hyperthermia


Gene context of Malignant Hyperthermia


Analytical, diagnostic and therapeutic context of Malignant Hyperthermia


  1. Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia. Quane, K.A., Healy, J.M., Keating, K.E., Manning, B.M., Couch, F.J., Palmucci, L.M., Doriguzzi, C., Fagerlund, T.H., Berg, K., Ording, H. Nat. Genet. (1993) [Pubmed]
  2. Neuroleptic malignant syndrome. Patient with unique clinical and physiologic features. Downey, G.P., Rosenberg, M., Caroff, S., Beck, S., Rosenberg, H., Gerber, J.C., Heiman-Patterson, T.D., Aronson, M.D. Am. J. Med. (1984) [Pubmed]
  3. Malignant hyperthermia. An allergic reaction to thioridazine therapy. Haberman, M.L. Arch. Intern. Med. (1978) [Pubmed]
  4. The nature of virus-like particles in the paraxial muscles of idiopathic scoliosis. Green, R.J., Webb, J.N., Maxwell, M.H. J. Pathol. (1979) [Pubmed]
  5. Discordance between phenotype and genotype in malignant hyperthermia. MacLennan, D.H. Curr. Opin. Neurol. (1995) [Pubmed]
  6. Neuroleptic malignant syndrome presenting without initial fever: a case report. Totten, V.Y., Hirschenstein, E., Hew, P. The Journal of emergency medicine. (1994) [Pubmed]
  7. Protection from halothane-induced porcine malignant hyperthermia syndrome by droperidol. McGrath, C.J., Rempel, W.E., Jessen, C.R., Addis, P.B., Crimi, A.J., Ruff, J. Lab. Anim. Sci. (1980) [Pubmed]
  8. Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease. Berchtold, M.W., Brinkmeier, H., Müntener, M. Physiol. Rev. (2000) [Pubmed]
  9. Increased myophosphorylase a in malignant hyperthermia. Willner, J.H., Wood, D.S., Cerri, C., Britt, B. N. Engl. J. Med. (1980) [Pubmed]
  10. Letter: Procaine for malignant hyperthermia. Giosa, N. N. Engl. J. Med. (1975) [Pubmed]
  11. Serum creatine kinase screening for susceptibility to malignant hyperthermia. Flewellen, E.H. JAMA (1986) [Pubmed]
  12. Intracellular calcium homeostasis in human primary muscle cells from malignant hyperthermia-susceptible and normal individuals. Effect Of overexpression of recombinant wild-type and Arg163Cys mutated ryanodine receptors. Censier, K., Urwyler, A., Zorzato, F., Treves, S. J. Clin. Invest. (1998) [Pubmed]
  13. High skeletal muscle adenylate cyclase in malignant hyperthermia. Willner, J.H., Cerri, C.G., Wood, D.S. J. Clin. Invest. (1981) [Pubmed]
  14. Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine. Foster, P.S., Gesini, E., Claudianos, C., Hopkinson, K.C., Denborough, M.A. Lancet (1989) [Pubmed]
  15. Diagnosis of susceptibility to malignant hyperthermia by use of a metabolic test. Anetseder, M., Hager, M., Müller, C.R., Roewer, N. Lancet (2002) [Pubmed]
  16. Propofol in malignant hyperthermia. Harrison, G.G. Lancet (1991) [Pubmed]
  17. Malignant hyperthermia. Denborough, M. Lancet (1998) [Pubmed]
  18. The human ryanodine receptor gene: its mapping to 19q13.1, placement in a chromosome 19 linkage group, and exclusion as the gene causing myotonic dystrophy. MacKenzie, A.E., Korneluk, R.G., Zorzato, F., Fujii, J., Phillips, M., Iles, D., Wieringa, B., Leblond, S., Bailly, J., Willard, H.F. Am. J. Hum. Genet. (1990) [Pubmed]
  19. Single-amino-acid deletion in the RYR1 gene, associated with malignant hyperthermia susceptibility and unusual contraction phenotype. Sambuughin, N., McWilliams, S., de Bantel, A., Sivakumar, K., Nelson, T.E. Am. J. Hum. Genet. (2001) [Pubmed]
  20. The substitution of Arg for Gly2433 in the human skeletal muscle ryanodine receptor is associated with malignant hyperthermia. Phillips, M.S., Khanna, V.K., De Leon, S., Frodis, W., Britt, B.A., MacLennan, D.H. Hum. Mol. Genet. (1994) [Pubmed]
  21. The porcine PHIcDNA linked to the halothane gene detects a NotI RFLP in normal and malignant hyperthermia susceptible pigs. Brenig, B., Jürs, S., Brem, G. Nucleic Acids Res. (1990) [Pubmed]
  22. Exclusion of defects in the skeletal muscle specific regions of the DHPR alpha 1 subunit as frequent causes of malignant hyperthermia. O'Brien, R.O., Taske, N.L., Hansbro, P.M., Matthaei, K.I., Hogan, S.P., Denborough, M.A., Foster, P.S. J. Med. Genet. (1995) [Pubmed]
  23. Effect of ryanodine receptor mutations on interleukin-6 release and intracellular calcium homeostasis in human myotubes from malignant hyperthermia-susceptible individuals and patients affected by central core disease. Ducreux, S., Zorzato, F., Müller, C., Sewry, C., Muntoni, F., Quinlivan, R., Restagno, G., Girard, T., Treves, S. J. Biol. Chem. (2004) [Pubmed]
  24. Adverse effects of drugs on muscle. Mastaglia, F.L. Drugs (1982) [Pubmed]
  25. Effects of Mg(2+) and SR luminal Ca(2+) on caffeine-induced Ca(2+) release in skeletal muscle from humans susceptible to malignant hyperthermia. Duke, A.M., Hopkins, P.M., Steele, D.S. J. Physiol. (Lond.) (2002) [Pubmed]
  26. Effects of beta- and alpha-adrenergic agonists, adenosine, and carbachol in heart muscle isolated from malignant hyperthermia susceptible swine. Böhm, M., Roewer, N., Schmitz, W., Scholz, H., Schulte am Esch, J. Anesthesiology (1988) [Pubmed]
  27. Detection of a novel RYR1 mutation in four malignant hyperthermia pedigrees. Keating, K.E., Quane, K.A., Manning, B.M., Lehane, M., Hartung, E., Censier, K., Urwyler, A., Klausnitzer, M., Muller, C.R., Heffron, J.J. Hum. Mol. Genet. (1994) [Pubmed]
  28. Exclusion of malignant hyperthermia susceptibility (MHS) from a putative MHS2 locus on chromosome 17q and of the alpha 1, beta 1, and gamma subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect. Sudbrak, R., Golla, A., Hogan, K., Powers, P., Gregg, R., Du Chesne, I., Lehmann-Horn, F., Deufel, T. Hum. Mol. Genet. (1993) [Pubmed]
  29. Identification of the Arg1086His mutation in the alpha subunit of the voltage-dependent calcium channel (CACNA1S) in a North American family with malignant hyperthermia. Stewart, S.L., Hogan, K., Rosenberg, H., Fletcher, J.E. Clin. Genet. (2001) [Pubmed]
  30. Genetic polymorphism of human plasma alpha 1B-glycoprotein: phenotyping by immunoblotting or by a simple method of 2-D electrophoresis. Gahne, B., Juneja, R.K., Stratil, A. Hum. Genet. (1987) [Pubmed]
  31. Genomic structure and functional expression of a human alpha(2)/delta calcium channel subunit gene (CACNA2). Schleithoff, L., Mehrke, G., Reutlinger, B., Lehmann-Horn, F. Genomics (1999) [Pubmed]
  32. Investigation of malignant hyperthermia: analysis of skeletal muscle proteins from normal and halothane sensitive pigs by two dimensional gel electrophoresis. Lorkin, P.A., Lehmann, H. J. Med. Genet. (1983) [Pubmed]
  33. Technetium-99m pyrophosphate scintigraphy in a patient with malignant hyperthermia. Murakawa, M., Hatano, Y., Mori, K., Torizuka, T., Tamaki, N., Iwasaki, R. J. Nucl. Med. (1989) [Pubmed]
  34. Improved noninvasive diagnostic testing for malignant hyperthermia susceptibility from a combination of metabolites determined in vivo with 31P-magnetic resonance spectroscopy. Payen, J.F., Bosson, J.L., Bourdon, L., Jacquot, C., Le Bas, J.F., Stieglitz, P., Benabid, A.L. Anesthesiology (1993) [Pubmed]
  35. Dantrolene in human malignant hyperthermia. Kolb, M.E., Horne, M.L., Martz, R. Anesthesiology (1982) [Pubmed]
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