Hyperphagia and obesity. Relationship to medial hypothalamic lesions.
Progressive left hemiparesis followed by face and trunk cutaneous vasodilation and hyperphagia developed in a 28-year-old man. He began eating five to six meals a day and gained 16 kg in 60 days. Computed tomography disclosed a neoplastic lesion involving the midline via the hypothalamus and reaching the contralateral lenticular nucleus. Findings from endocrine studies, including thyroid-stimulating hormone, growth hormone, prolactin, and cortisol serum levels, were normal. Hyperphagia and consequent obesity were associated with bilateral destruction of the ventromedial hypothalamic area; cutaneous vasodilation was related to involvement of the preoptic area.[1]References
- Hyperphagia and obesity. Relationship to medial hypothalamic lesions. Celesia, G.G., Archer, C.R., Chung, H.D. JAMA (1981) [Pubmed]
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