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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Prostaglandins modulate macrophage Ia expression.

Prostaglandins are important modulators of inflammation and of humoral and cellular immune responses. In order to evaluate a possible mechanism for the regulation of immune responses we have studied the effects of prostaglandins on the expression of I-region-associated (Ia) antigens by macrophages. The expression of these glycoproteins is essential for macrophages to function as antigen-presenting cells during the induction of immune responses. The synthesis and membrane expression of Ia, however, is not a constitutive property of the phagocyte but is under regulation and a positive regulation of this process is exhibited by activated T cells. In contrast, a negative regulation is conspicuously found in the neonate where a product from a young replicating macrophage inhibits the expression of Ia by the mature macrophages. We show here that prostaglandins of the E series (PGE) are potent inhibitors of the expression of Ia-antigens on macrophages and that thromboxane B2 (TXB2) antagonizes the effect of PGE.[1]


  1. Prostaglandins modulate macrophage Ia expression. Snyder, D.S., Beller, D.I., Unanue, E.R. Nature (1982) [Pubmed]
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