The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cyclic GABA-GABOB analogues. II - Synthesis of new 2-oxo and 2,5-dioxo-delta3-pyrroline derivatives.

Within the framework of a research program on new compounds potentially active on learning and memory processes, some esters and amides of 2-oxo- and 2,5-dioxo-delta3-pyrroline-1-acetic acids were synthesized. Such compounds can be regarded either as dehydration products of the corresponding 4-hydroxy-2-pyrrolidinones or as cyclic derivatives of 4-aminoisocrotonic acid. Two approaches were used in an attempt to synthesize pyrrolinone derivatives. One method involved the direct alkylation with ethyl bromoacetate of 1,5-dihydro-2H-pyrrol-2-one (III b), obtained for the first time in pure form by cyclization of 4-amino-3-hydroxybutyric acid (GABOB). Another approach involved the preparation of the ethyl 3-bromo-2-oxo-1-pyrrolidineacetate (VI), by cyclization of N-(2,4-dibromobutyryl)glycine ethyl ester (V), and its 4-bromo isomer (X b) by bromination of ethyl 4-hydroxy-2-oxo-1-pyrrolidineacetate (X a). While the dehydrobromination of (VI) was unsuccessful, heating of (X b) with TEA afforded ethyl 2,5-dihydro-2-oxo-1H-pyrrole-1-acetate (IV a). Alternatively, (X a) was treated with methanesulfonyl chloride, then with TEA to give (IV a). Final ammonolysis of (IV a) provided the corresponding amide (IV b). For the synthesis of the maleimide analogue (XIII b), the N-(carboxymethyl)maleamic acid (XII a) was treated with PCl5 and then with anhydrous ammonia.[1]


WikiGenes - Universities