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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes.

Two cloned Drosophila sequences, Dash and Dsrc, were previously isolated by hybridization to the viral oncogenes v-abl and v-src. We report that the Drosophila DNA sequences are more than 50% homologous to 700 base pairs of the vertebrate oncogenes that are essential for kinase activity of the v-abl and the v-src gene products. Alignment of the predicted amino acid sequences in the homologous regions shows amino acid sequence identities of 74% between Dash and the 5' portion of v-abl and of 54% between Dsrc and 3' portion of v-src. Comparison of the Drosophila and vertebrate sequences identifies amino acids that may be essential for the distinct functions of the c-src and the c-abl gene products and places the gene duplication event that has generated the two genes prior to the Chordate-Arthropod divergence.[1]

References

  1. Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes. Hoffmann, F.M., Fresco, L.D., Hoffman-Falk, H., Shilo, B.Z. Cell (1983) [Pubmed]
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