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Gene Review

Src64B  -  Src oncogene at 64B

Drosophila melanogaster

Synonyms: C-src1, CG7524, D-Src64B, D-src, DSRC64, ...
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Disease relevance of Src64B


High impact information on Src64B

  • Drosophila ring canal growth requires Src and Tec kinases [3].
  • We conclude that c-src may not be a mitotic signal but instead may play a role in the development of neural tissue and smooth muscle [4].
  • Drosophila c-src RNA is abundant in embryos and pupae but rare in larvae and adults [4].
  • The nucleotide sequence and the tissue-specific expression of Drosophila c-src [4].
  • We have examined the coding capability and expression of the Drosophila homolog of the vertebrate proto-oncogene c-src [4].

Biological context of Src64B


Anatomical context of Src64B

  • Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells [5].
  • These data, along with changes in G-actin accumulation in the oocyte nucleus, suggest that Src64 is involved in a nuclear actin function during karyosome condensation [9].
  • Src family tyrosine kinases respond to a variety of signals by regulating the organization of the actin cytoskeleton [9].
  • The results are discussed in relation to potential roles for the vertebrate homologues of Drk and Csw (Grb2 and SHP2, respectively) in the transformation of fibroblasts by vertebrate Src [10].
  • Analogous mutations in Drosophila Src64 (DSrc) induce abnormal differentiation of photoreceptor cells when expressed ectopically in the developing Drosophila adult eye [10].

Associations of Src64B with chemical compounds

  • The Src family protein tyrosine kinases (SFKs) are crucial regulators of cellular morphology [5].
  • This novel APPL-interacting protein 1 (APLIP1) contains a Src homology 3 domain and a phosphotyrosine interaction domain and is expressed abundantly in neural tissues [11].

Enzymatic interactions of Src64B

  • Src64 regulates this process by phosphorylating Y677 within the kinase domain of Tec29, an event required for Tec29 activation [12].

Regulatory relationships of Src64B

  • Recent studies have identified key Src64-dependent mechanisms that regulate actin cytoskeletal dynamics during the growth of actin-rich ring canals, which act as intercellular bridges between germ cells [5].
  • We find that dominant-negative mutations in either the drk or csw genes ameliorate the developmental abnormalities induced by activated DSrc [10].

Other interactions of Src64B

  • Overexpression of either wild-type Drosophila SFK (Src64 and Src42) is sufficient to induce ectopic proliferation in G1/G0-arrested, uncommitted cells in eye imaginal discs [6].
  • Strikingly, Src64 and Csk function in the germline to control packaging, not in migrating follicle cells, suggesting novel functions for this signaling cassette in regulating dynamic adhesion [5].
  • Signaling by ectopically expressed Drosophila Src64 requires the protein-tyrosine phosphatase corkscrew and the adapter downstream of receptor kinases [10].
  • Upon stimulation of the bombesin receptors, KUZ increases the docking and activation of adaptors Src homology 2 domain-containing protein and Gab1 on the EGFR, and activation of Ras and Erk [13].
  • Alignment of the predicted amino acid sequences in the homologous regions shows amino acid sequence identities of 74% between Dash and the 5' portion of v-abl and of 54% between Dsrc and 3' portion of v-src [8].

Analytical, diagnostic and therapeutic context of Src64B

  • The consequences of deregulated Src activity have been studied extensively in cell culture; however, the effects of this deregulation in vivo, as well as the mechanisms of Src-induced tumorigenesis, remain poorly understood [6].
  • In situ hybridization reveals that after the first 8 hr of development, c-src RNA accumulates almost exclusively in neural tissues such as the brain, ventral nerve chord, and eye-antennal discs, and in differentiating smooth muscle [4].
  • Sequence analysis of a cDNA clone representing the Drosophila c-src locus suggests that the gene encodes a 62 kd protein that is remarkably similar to the protein product of chicken c-src [4].


  1. From c-src to v-src, or the case of the missing C terminus. Sefton, B.M., Hunter, T. Cancer Surv. (1986) [Pubmed]
  2. Involvement of FAK/Src complex in the processes of Escherichia coli phagocytosis by insect hemocytes. Metheniti, A., Paraskevopoulou, N., Lambropoulou, M., Marmaras, V.J. FEBS Lett. (2001) [Pubmed]
  3. Drosophila ring canal growth requires Src and Tec kinases. Cooley, L. Cell (1998) [Pubmed]
  4. The nucleotide sequence and the tissue-specific expression of Drosophila c-src. Simon, M.A., Drees, B., Kornberg, T., Bishop, J.M. Cell (1985) [Pubmed]
  5. Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells. O'Reilly, A.M., Ballew, A.C., Miyazawa, B., Stocker, H., Hafen, E., Simon, M.A. Development (2006) [Pubmed]
  6. Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis. Pedraza, L.G., Stewart, R.A., Li, D.M., Xu, T. Oncogene (2004) [Pubmed]
  7. The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development. Roulier, E.M., Panzer, S., Beckendorf, S.K. Mol. Cell (1998) [Pubmed]
  8. Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes. Hoffmann, F.M., Fresco, L.D., Hoffman-Falk, H., Shilo, B.Z. Cell (1983) [Pubmed]
  9. Src64 is involved in fusome development and karyosome formation during Drosophila oogenesis. Djagaeva, I., Doronkin, S., Beckendorf, S.K. Dev. Biol. (2005) [Pubmed]
  10. Signaling by ectopically expressed Drosophila Src64 requires the protein-tyrosine phosphatase corkscrew and the adapter downstream of receptor kinases. Cooper, J.A., Simon, M.A., Kussick, S.J. Cell Growth Differ. (1996) [Pubmed]
  11. Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. Taru, H., Iijima, K., Hase, M., Kirino, Y., Yagi, Y., Suzuki, T. J. Biol. Chem. (2002) [Pubmed]
  12. Localization of Tec29 to ring canals is mediated by Src64 and PtdIns(3,4,5)P3-dependent mechanisms. Lu, N., Guarnieri, D.J., Simon, M.A. EMBO J. (2004) [Pubmed]
  13. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. Yan, Y., Shirakabe, K., Werb, Z. J. Cell Biol. (2002) [Pubmed]
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