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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, src

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Disease relevance of Genes, src


High impact information on Genes, src

  • We examine the interaction between polyoma-virus-encoded middle tumor antigen and the cellular src gene product, pp60c-src, using a series of monoclonal antibodies that recognize mammalian pp60c-src [6].
  • The c-src gene consists of 12 exons; the boundaries of the exons were determined by assuming that the amino acid sequence of its product, pp60c-src, is basically the same as that of pp60v-src [7].
  • Several strains of ASV were compared with respect to these sites, and the sites have been located in relation to deletions frequently observed in the env and src genes of ASV [8].
  • The tyrosine kinasee activity of p60c-src, the protein product of the c-src gene, increases during mitosis; this may be important in initiating at least some of the cellular changes that occur during this phase of the cell cycle [9].
  • The viral src gene is derived from a cellular gene (c-src) which also encodes a 60,000 MW phosphoprotein (pp60c-src) with tyrosine-specific protein kinase activity [10].

Chemical compound and disease context of Genes, src


Biological context of Genes, src


Anatomical context of Genes, src


Associations of Genes, src with chemical compounds


Gene context of Genes, src


Analytical, diagnostic and therapeutic context of Genes, src


  1. Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases. Hughes, S.H., Payvar, F., Spector, D., Schimke, R.T., Robinson, H.L., Payne, G.S., Bishop, J.M., Varmus, H.E. Cell (1979) [Pubmed]
  2. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Ellis, R.W., Defeo, D., Shih, T.Y., Gonda, M.A., Young, H.A., Tsuchida, N., Lowy, D.R., Scolnick, E.M. Nature (1981) [Pubmed]
  3. Murine hematopoietic cells with pre-B or pre-B/myeloid characteristics are generated by in vitro transformation with retroviruses containing fes, ras, abl, and src oncogenes. Holmes, K.L., Pierce, J.H., Davidson, W.F., Morse, H.C. J. Exp. Med. (1986) [Pubmed]
  4. Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. Iba, H., Takeya, T., Cross, F.R., Hanafusa, T., Hanafusa, H. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  5. Markedly elevated levels of an endogenous sarc protein in a hemopoietic precursor cell line. Scolnick, E.M., Weeks, M.O., Shih, T.Y., Ruscetti, S.K., Dexter, T.M. Mol. Cell. Biol. (1981) [Pubmed]
  6. Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation. Bolen, J.B., Thiele, C.J., Israel, M.A., Yonemoto, W., Lipsich, L.A., Brugge, J.S. Cell (1984) [Pubmed]
  7. Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus. Takeya, T., Hanafusa, H. Cell (1983) [Pubmed]
  8. Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Shank, P.R., Hughes, S.H., Kung, H.J., Majors, J.E., Quintrell, N., Guntaka, R.V., Bishop, J.M., Varmus, H.E. Cell (1978) [Pubmed]
  9. Altered tyrosine 527 phosphorylation and mitotic activation of p60c-src. Bagrodia, S., Chackalaparampil, I., Kmiecik, T.E., Shalloway, D. Nature (1991) [Pubmed]
  10. Three loci related to the src oncogene and tyrosine-specific protein kinase activity in Drosophila. Simon, M.A., Kornberg, T.B., Bishop, J.M. Nature (1983) [Pubmed]
  11. Reversal of Rous sarcoma-specific immunoglobulin phosphorylation on tyrosine (ADP as phosphate acceptor) catalyzed by the src gene kinase. Fukami, Y., Lipmann, F. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  12. Short-term treatment with gamma interferon induces stable reversion of ras-transformed mouse fibroblasts. Seliger, B., Pfizenmaier, K., Schäfer, R. J. Virol. (1991) [Pubmed]
  13. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. Behrens, J., Vakaet, L., Friis, R., Winterhager, E., Van Roy, F., Mareel, M.M., Birchmeier, W. J. Cell Biol. (1993) [Pubmed]
  14. Endogenous c-src as a determinant of the tumorigenicity of src oncogenes. Halpern, M.S., England, J.M., Kopen, G.C., Christou, A.A., Taylor, R.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  15. Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes. Nishimura, J., Huang, J.S., Deuel, T.F. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  16. Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src. Anderson, S.K., Gibbs, C.P., Tanaka, A., Kung, H.J., Fujita, D.J. Mol. Cell. Biol. (1985) [Pubmed]
  17. Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells. Johnson, P.J., Coussens, P.M., Danko, A.V., Shalloway, D. Mol. Cell. Biol. (1985) [Pubmed]
  18. Transformation of Rat-1 fibroblasts with the v-src oncogene increases the tyrosine phosphorylation state and activity of the alpha subunit of Gq/G11. Liu, W.W., Mattingly, R.R., Garrison, J.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  19. Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs. Chaturvedi, P., Sharma, S., Reddy, E.P. Mol. Cell. Biol. (1997) [Pubmed]
  20. v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element. Xie, W., Fletcher, B.S., Andersen, R.D., Herschman, H.R. Mol. Cell. Biol. (1994) [Pubmed]
  21. myc and src oncogenes have complementary effects on cell proliferation and expression of specific extracellular matrix components in definitive chondroblasts. Alema, S., Tato, F., Boettiger, D. Mol. Cell. Biol. (1985) [Pubmed]
  22. Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin. Chao, T.S., Abe, M., Hershenson, M.B., Gomes, I., Rosner, M.R. Cancer Res. (1997) [Pubmed]
  23. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Flier, J.S., Mueckler, M.M., Usher, P., Lodish, H.F. Science (1987) [Pubmed]
  24. Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes. Diaz-Laviada, I., Larrodera, P., Diaz-Meco, M.T., Cornet, M.E., Guddal, P.H., Johansen, T., Moscat, J. EMBO J. (1990) [Pubmed]
  25. Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene. Wasilenko, W.J., Payne, D.M., Fitzgerald, D.L., Weber, M.J. Mol. Cell. Biol. (1991) [Pubmed]
  26. The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant. Kaplan, J.M., Mardon, G., Bishop, J.M., Varmus, H.E. Mol. Cell. Biol. (1988) [Pubmed]
  27. Mutation of amino acids in pp60c-src that are phosphorylated by protein kinases C and A. Yaciuk, P., Choi, J.K., Shalloway, D. Mol. Cell. Biol. (1989) [Pubmed]
  28. Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex. Birchenall-Roberts, M.C., Ruscetti, F.W., Kasper, J., Lee, H.D., Friedman, R., Geiser, A., Sporn, M.B., Roberts, A.B., Kim, S.J. Mol. Cell. Biol. (1990) [Pubmed]
  29. Insulin-like growth factor I receptor signaling in transformation by src oncogenes. Valentinis, B., Morrione, A., Taylor, S.J., Baserga, R. Mol. Cell. Biol. (1997) [Pubmed]
  30. Effect of infection with murine recombinant retroviruses containing the v-src oncogene on interleukin 2- and interleukin 3-dependent growth states. Watson, J.D., Eszes, M., Overell, R., Conlon, P., Widmer, M., Gillis, S. J. Immunol. (1987) [Pubmed]
  31. Review of the in vivo functions of the p160 steroid receptor coactivator family. Xu, J., Li, Q. Mol. Endocrinol. (2003) [Pubmed]
  32. Down-modulation of EGF receptors in cells transformed by the src oncogene. Wasilenko, W.J., Shawver, L.K., Weber, M.J. J. Cell. Physiol. (1987) [Pubmed]
  33. Factor-dependent erythroid cell lines derived from mice transplanted with hematopoietic cells expressing the v-src oncogene. Kennedy, M., Beug, H., Wagner, E.F., Keller, G. Blood (1992) [Pubmed]
  34. Mapping of three unique Ca(2+)-binding sites in human annexin II. Jost, M., Thiel, C., Weber, K., Gerke, V. Eur. J. Biochem. (1992) [Pubmed]
  35. Antibodies specific for the neuronal form of the Src protein elicited by an antigenized antibody. Rigaudy, P., Simon, S., Hunter, T., Sollazzo, M., Billetta, R., Zanetti, M., Eckhart, W. DNA Cell Biol. (1994) [Pubmed]
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