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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, abl

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Disease relevance of Genes, abl


High impact information on Genes, abl

  • Dominant negative MYC blocks transformation by ABL oncogenes [6].
  • Within 24 hr, 85% of the dimers were removed from the 20 kb intragenic BamHl restriction fragment of the expressed c-abl gene, while only 22% of the dimers were removed from the 15 kb EcoRl fragment that spans the transcriptionally inactive c-mos locus [7].
  • One of the known responses to ionizing radiation is the activation of a nuclear tyrosine kinase encoded by the c-abl proto-oncogene [8].
  • However, cells expressing the dominant-negative c-Abl mutant and cells lacking the c-abl gene are impaired in their ability to downregulate Cdk2 or undergo G1 arrest in response to ionizing radiation [9].
  • The Drosophila abelson (abl) gene encodes the homolog of the mammalian c-abl cytoplasmic tyrosine kinase and is an essential gene for the development of viable adult flies [10].

Chemical compound and disease context of Genes, abl


Biological context of Genes, abl


Anatomical context of Genes, abl


Associations of Genes, abl with chemical compounds

  • The product of the c-abl gene is a non-receptor tyrosine kinase that is localized to the nucleus and cytoplasm [25].
  • Mechanisms mediating loss of IL-7 dependence are different depending on whether the raf or abl gene is present in myc-containing viruses [26].
  • However, AATYK expression is induced in 32D cells transformed by the v-abl gene when these cells are incubated in the presence of DMSO, which induces growth arrest and apoptotic death of the cells [27].
  • M-IBDET and A-IBDAT selectively suppress the v-abl oncogene as well as Moloney murine leukemia virus production [28].
  • In comparison, ras and abl oncogenes enhanced 2-DOG uptake by 72-112%, associated with a 2-fold greater transporter affinity for glucose [29].

Gene context of Genes, abl


Analytical, diagnostic and therapeutic context of Genes, abl


  1. An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene. Rosenbaum, H., Harris, A.W., Bath, M.L., McNeall, J., Webb, E., Adams, J.M., Cory, S. EMBO J. (1990) [Pubmed]
  2. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Kelliher, M.A., McLaughlin, J., Witte, O.N., Rosenberg, N. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine. Kipreos, E.T., Lee, G.J., Wang, J.Y. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  4. Nuclear localization of v-Abl leads to complex formation with cyclic AMP response element (CRE)-binding protein and transactivation through CRE motifs. Birchenall-Roberts, M.C., Ruscetti, F.W., Kasper, J.J., Bertolette, D.C., Yoo, Y.D., Bang, O.S., Roberts, M.S., Turley, J.M., Ferris, D.K., Kim, S.J. Mol. Cell. Biol. (1995) [Pubmed]
  5. Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase. Jain, S.K., Langdon, W.Y., Varticovski, L. Oncogene (1997) [Pubmed]
  6. Dominant negative MYC blocks transformation by ABL oncogenes. Sawyers, C.L., Callahan, W., Witte, O.N. Cell (1992) [Pubmed]
  7. Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos. Madhani, H.D., Bohr, V.A., Hanawalt, P.C. Cell (1986) [Pubmed]
  8. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Baskaran, R., Wood, L.D., Whitaker, L.L., Canman, C.E., Morgan, S.E., Xu, Y., Barlow, C., Baltimore, D., Wynshaw-Boris, A., Kastan, M.B., Wang, J.Y. Nature (1997) [Pubmed]
  9. Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Yuan, Z.M., Huang, Y., Whang, Y., Sawyers, C., Weichselbaum, R., Kharbanda, S., Kufe, D. Nature (1996) [Pubmed]
  10. Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog. Gertler, F.B., Doctor, J.S., Hoffmann, F.M. Science (1990) [Pubmed]
  11. Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein. Schwartzberg, P.L., Robertson, E.J., Goff, S.P. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  12. v-Abl activates c-myc transcription through the E2F site. Wong, K.K., Zou, X., Merrell, K.T., Patel, A.J., Marcu, K.B., Chellappan, S., Calame, K. Mol. Cell. Biol. (1995) [Pubmed]
  13. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Roche-Lestienne, C., Soenen-Cornu, V., Grardel-Duflos, N., Laï, J.L., Philippe, N., Facon, T., Fenaux, P., Preudhomme, C. Blood (2002) [Pubmed]
  14. Protein phosphorylation at tyrosine residues in v-abl transformed mouse lymphocytes and fibroblasts. Saggioro, D., Ferracini, R., Di Renzo, M.F., Naldini, L., Chieco-Bianchi, L., Comoglio, P.M. Int. J. Cancer (1986) [Pubmed]
  15. Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity. Kipreos, E.T., Wang, J.Y. Science (1990) [Pubmed]
  16. Restriction fragment length polymorphism caused by a deletion within the human c-abl gene (ABL). Xu, D.Q., Galibert, F. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  17. Abelson virus transformation of an interleukin 2-dependent antigen-specific T-cell line. Cook, W.D., Fazekas de St Groth, B., Miller, J.F., MacDonald, H.R., Gabathuler, R. Mol. Cell. Biol. (1987) [Pubmed]
  18. Induction of erythroid differentiation of K562 human leukemic cells by herbimycin A, an inhibitor of tyrosine kinase activity. Honma, Y., Okabe-Kado, J., Hozumi, M., Uehara, Y., Mizuno, S. Cancer Res. (1989) [Pubmed]
  19. Transgenes encoding both type I and type IV c-abl proteins rescue the lethality of c-abl mutant mice. Hardin, J.D., Boast, S., Mendelsohn, M., de los Santos, K., Goff, S.P. Oncogene (1996) [Pubmed]
  20. Restricted oncogenicity of BCR/ABL p190 in transgenic mice. Voncken, J.W., Griffiths, S., Greaves, M.F., Pattengale, P.K., Heisterkamp, N., Groffen, J. Cancer Res. (1992) [Pubmed]
  21. The hemopoietic progenitor 32DCl3(G) cells synthesize C3 molecules and acquire C3b acceptor sites upon differentiation or neoplastic transformation. Di Renzo, L., Zicari, A., Longo, A., Realacci, M., Naso, G., Pontieri, G., Lipari, M. J. Immunol. (1993) [Pubmed]
  22. Analysis of A-MuLV transformed fibroblast lines for amplification of the c-myc, p53 and c-fos nuclear proto-oncogenes. Colledge, W.H., Gebhardt, A., Edge, M.D., Bell, J.C. Oncogene (1989) [Pubmed]
  23. Generation of recombinant murine retroviral genomes containing the v-src oncogene: isolation of a virus inducing hemangiosarcomas in the brain. Hevezi, P., Goff, S.P. J. Virol. (1991) [Pubmed]
  24. Analysis of CD34 populations in mobilised peripheral blood stem cell harvests and in bone marrow by fluorescent in situ hybridisation for the bcr/abl gene fusion in patients with chronic granulocytic leukaemia. Irving, J.A., Lennard, A., Storey, N., Conn, J., Dunn, J., Oliver, K., Proctor, S.J., Dickinson, A.M. Leukemia (1999) [Pubmed]
  25. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Kharbanda, S., Ren, R., Pandey, P., Shafman, T.D., Feller, S.M., Weichselbaum, R.R., Kufe, D.W. Nature (1995) [Pubmed]
  26. Interaction of abl and raf with IL-7 signaling pathway and transformation of pre-B cells from resistant mice. Hilbert, D.M., Theisen, P.W., Rudikoff, E.K., Bauer, S.R. Oncogene (1998) [Pubmed]
  27. AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Gaozza, E., Baker, S.J., Vora, R.K., Reddy, E.P. Oncogene (1997) [Pubmed]
  28. Selective repression of v-abl-encoded protein by N-methylisatin-beta-4',4'-diethylthiosemicarbazone and N-allylisatin-beta-4',4'-diallylthiosemicarbazone. Teitz, Y., Ladizensky, E., Barko, N., Burstein, E. Antimicrob. Agents Chemother. (1993) [Pubmed]
  29. Distinct regulation of glucose transport by interleukin-3 and oncogenes in a murine bone marrow-derived cell line. Ahmed, N., Berridge, M.V. Biochem. Pharmacol. (1999) [Pubmed]
  30. Signaling by ABL oncogenes through cyclin D1. Afar, D.E., McLaughlin, J., Sherr, C.J., Witte, O.N., Roussel, M.F. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  31. Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells. Weissinger, E.M., Eissner, G., Grammer, C., Fackler, S., Haefner, B., Yoon, L.S., Lu, K.S., Bazarov, A., Sedivy, J.M., Mischak, H., Kolch, W. Mol. Cell. Biol. (1997) [Pubmed]
  32. Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Sexl, V., Piekorz, R., Moriggl, R., Rohrer, J., Brown, M.P., Bunting, K.D., Rothammer, K., Roussel, M.F., Ihle, J.N. Blood (2000) [Pubmed]
  33. The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase. Million, R.P., Van Etten, R.A. Blood (2000) [Pubmed]
  34. Patterns of BCR/ABL gene rearrangements by interphase fluorescence in situ hybridization (FISH) in BCR/ABL+ leukemias: incidence and underlying genetic abnormalities. Primo, D., Tabernero, M.D., Rasillo, A., Sayagués, J.M., Espinosa, A.B., Chillón, M.C., Garcia-Sanz, R., Gutierrez, N., Giralt, M., Hagemeijer, A., San Miguel, J.F., Orfao, A. Leukemia (2003) [Pubmed]
  35. Philadelphia chromosome positive precursor B-cell acute lymphoblastic leukemia with a translocation t(2;14)(p13;q32). Inaba, T., Oku, N., Gotoh, H., Murakami, S., Oku, N., Itoh, K., Ura, Y., Nakanishi, S., Shimazaki, C., Nakagawa, M. Leukemia (1991) [Pubmed]
  36. Transfection of the bcr/abl oncogene into factor-dependent cells by electroporation: acquisition of autonomous proliferation. Takahashi, M., Furukawa, T., Tanaka, I., Ohsawa, Y., Nikkuni, K., Oaki, A., Goto, T., Hashimoto, T., Kishi, K., Koike, T. Hematological oncology. (1994) [Pubmed]
  37. Molecular cloning and serological characterization of an altered c-abl gene product produced in Ph1 CML patients. Mes-Masson, A.M., McLaughlin, J., Witte, O. Haematology and blood transfusion. (1987) [Pubmed]
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