The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Recent methods for assessing effectiveness of antihypertensive agents.

Clinically relevant graphic approaches to the assessment of patients' blood pressure responses to antihypertensive agents are reviewed and extended to include both statistical components and the effects of treatment-related patient discontinuations. Regression line fits of change in diastolic blood pressure (DBP) versus baseline diastolic blood pressure ( BDBP) are used for multicenter comparisons of placebo, guanabenz, methyldopa, clonidine, propranolol, hydrochlorothiazide, and the combination of guanabenz plus hydrochlorothiazide. Orientations of the fitted lines can be contrasted to certain "ideal" response profiles and are particularly useful for comparative purposes. An additional graphic approach was developed to show overall "therapeutic" response rate categories, two of which account for patients discontinuing treatment because of nonresponse or adverse effects. This approach assesses antihypertensive effectiveness, "adjusted" for the effects of treatment-related patient withdrawal, thus addressing criticisms often raised in the evaluation of such agents. Although these methods are generally useful for comparing agents used in chronic disease therapy, further work is needed to extend these procedures to incorporate safety assessments and overall benefit-risk considerations in the selection of treatment modalities.[1]


  1. Recent methods for assessing effectiveness of antihypertensive agents. Schneider, B.E., Littman, G.S., Walker, B.R. Clinical therapeutics. (1983) [Pubmed]
WikiGenes - Universities