The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound

Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

[search][options]

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Kurihara, A. et al.

Analysis of the effect of an anti-inflammatory steroid, dexamethasone, on neutrophil chemotaxis in the Boyden chamber with a modified 51Cr-labeling method.

For the determination of leukocyte chemotaxis in the Boyden chamber toward zymosan-activated serum, a modification of the 51Cr-labeling method originally introduced by Gallin et al. was made using a polycarbonate filter at the top of a double filter system. By application of this method, it was demonstrated that an anti-inflammatory steroid, dexamethasone at relatively low doses, directly inhibited chemotactic movement of leukocytes after the pretreatment of the cells with dexamethasone for several hours. This inhibitory effect was proved to be a common property of glucocorticoids. The leukocyte-inhibitory effect manifested within the cell body and the release of any extracellular factors mediating the inhibitory effect of the corticoid into the medium was not demonstrated. The present data suggests that the inhibitory effect of dexamethasone on leukocyte infiltration observed in vivo is attributed to the direct inhibitory effect of dexamethasone on the motility of leukocytes.[1]

References

Analysis of the effect of an anti-inflammatory steroid, dexamethasone, on neutrophil chemotaxis in the Boyden chamber with a modified 51Cr-labeling method. Kurihara, A., Ojima, F., Tsurufuji, S. J. Pharmacobio-dyn. (1984) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg