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Chemical Compound Review

Gallin     2-(3,4,5,6-tetrahydroxy-9H- xanthen-9...

Synonyms: AG-K-08596, AC1L4SCG, CTK5A2518, AR-1C7042, AC1Q5U89, ...
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Disease relevance of Gallin

  • In several of these neutrophil abnormalities, ie, neutrophil actin dysfunction, Chédiak-Higashi syndrome, and its "antithesis" described by Gallin and co-workers, the cellular dysfunctions were well documented but the molecular basis was completely obscure prior to cell biologic analysis [1].

High impact information on Gallin

  • Chemotaxis of adult and newborn PMNs was studied with a modified Gallin radiolabel technique [2].
  • The altered feather pattern obtained by disrupting proteoglycan structure is highly similar to that obtained when skins are cultured in the presence of antibodies to L-CAM (W.J. Gallin, C.-M., Chuong, L.H. Finkel, and G.M. Edelman (1986), Proc. Natl. Acad. Sci. USA 83, 8235-8239) [3].
  • Hyperpolarization in human leukemia THP-1 monocytes adherent to vascular cell adhesion molecule (VCAM)-1 is due to an induction of inwardly rectifying K(+) currents (I(ir)) (Colden-Stanfield M and Gallin EK, Am J Physiol Cell Physiol 275: C267-C277, 1998) [4].

Anatomical context of Gallin

  • For the determination of leukocyte chemotaxis in the Boyden chamber toward zymosan-activated serum, a modification of the 51Cr-labeling method originally introduced by Gallin et al. was made using a polycarbonate filter at the top of a double filter system [5].


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